Elizabeth F Maughan,Robert E Hynds,Toby J Proctor et al.
Elizabeth F Maughan et al.
Purpose of review: There is no consensus on the best technology to be employed for tracheal replacement. One particularly promising approach is based upon tissue engineering and involves applying autologous cells to trans...
Organoid and Organ-On-A-Chip Systems: New Paradigms for Modeling Neurological and Gastrointestinal Disease [0.03%]
类器官和芯片器官系统：模拟神经和胃肠疾病的新型模型
Aslam Abbasi Akhtar,Samuel Sances,Robert Barrett et al.
Aslam Abbasi Akhtar et al.
Purpose of review: The modeling of biological processes in vitro provides an important tool to better understand mechanisms of development and disease, allowing for the rapid testing of therapeutics. However, a critical c...
Synergistic Development of Biochips and Cell Preservation Methodologies: A Tale of Converging Technologies [0.03%]
生物芯片和细胞保存技术的协同开发：融合技术的故事
Shangping Wang,Gloria D Elliott
Shangping Wang
Purpose of the review: Over the past several decades, cryopreservation has been widely used to preserve cells during long term storage, but advances in stem cell therapies, regenerative medicine, and miniaturized cell-bas...
Miyeko D Mana,Elaine Yih-Shuen Kuo,Ömer H Yilmaz
Miyeko D Mana
Purpose of review: Dietary intake is a critical regulator of organismal physiology and health. Tissue homeostasis and regeneration are dependent on adult tissue stem cells that self-renew and differentiate into the specia...
Ahmet Alptekin,Bingwei Ye,Han-Fei Ding
Ahmet Alptekin
Purpose of review: Metabolism is increasingly recognized as a major player in control of stem cell function and fate. How stem cell metabolism is established, maintained, and regulated is a fundamental question of biology...
Laura M Marquardt,Sarah C Heilshorn
Laura M Marquardt
Stem cell-based therapies are steadily gaining traction for regenerative medicine approaches to treating disease and injury throughout the body. While a significant body of work has shown success in preclinical studies, results often fail t...
Hanna L Sladitschek,Pierre A Neveu
Hanna L Sladitschek
Purpose of review: Stem cells have to balance self-renewal and differentiation. The dynamic nature of these fate decisions has made stem cell study by traditional methods particularly challenging. Here we highlight recent...
Fabio Pereira Lampreia,Joana Gonçalves Carmelo,Fernando Anjos-Afonso
Fabio Pereira Lampreia
Purpose of review: Understanding the signaling pathways that govern hematopoietic stem and progenitor cells (HSPCs) is fundamental to uncover their regulation and how this is skewed in hematological malignancies. Whether ...
Mateusz Adamiak,Mariusz Z Ratajczak
Mateusz Adamiak
Purpose of review: Several mechanisms have been postulated to orchestrate mobilization of hematopoietic stem/progenitor cells (HSPCs), and still more work is needed to better understand this process and to gain better mec...
Xinyue Chen,Amaleah Hartman,Shangqin Guo
Xinyue Chen
A close relationship between proliferation and cell fate specification has been well documented in many developmental systems. In addition to the gradual cell fate changes accompanying normal development and tissue homeostasis, it is now co...