Amir Alhajjat,Aimen Shaaban
Amir Alhajjat
Purpose of review: In Utero Hematopoietic Cellular Transplantation (IUHCT) is a promising intervention for the non-toxic treatment of congenital disease that hinges on the assumption of fetal immunologic immaturity and an...
Soo J Park,Rafael Bejar
Soo J Park
Purpose of review: Clonal hematopoiesis of indeterminate potential (CHIP) is a common, age-associated condition characterized by the acquisition of somatic mutations. This concise review explores our current understanding...
Tuning of the Hematopoietic Stem Cell Compartment in its Inflammatory Environment [0.03%]
造血干细胞库在炎症环境中的调节
Vinothini Govindarajah,Damien Reynaud
Vinothini Govindarajah
Purpose of review: The hematopoietic stem cell (HSC) compartment is the cornerstone of a lifelong blood cell production but also contributes to the ability of the hematopoietic system to dynamically respond to environment...
Human iPSC Models to Study Orphan Diseases: Muscular Dystrophies [0.03%]
用于研究罕见病的单基因遗传病的诱导多能干细胞模型：肌肉营养不良病症
Guangbin Xia,Naohiro Terada,Tetsuo Ashizawa
Guangbin Xia
Purpose of review: Muscular dystrophies (MDs) are a spectrum of muscle disorders, which are caused by a number of gene mutations. The studies of MDs are limited due to lack of appropriate models, except for Duchenne muscu...
Elisa Lazzari,Jason M Butler
Elisa Lazzari
Purpose of review: In this review, we aim to discuss the role of the bone marrow microenvironment in supporting hematopoiesis, with particular focus on the contribution of the endothelial niche in dictating hematopoietic ...
Nathaniel Magilnick,Mark P Boldin
Nathaniel Magilnick
Purpose of review: Hematopoiesis is an ordered developmental process that requires dynamic regulation to warrant proper response to physiological challenges and prevent malignancies. Long noncoding RNAs are emerging as ke...
The Role of Interferon-Gamma in Hematopoietic Stem Cell Development, Homeostasis, and Disease [0.03%]
干扰素-γ在造血干细胞发育、稳态及疾病中的作用
Daniel E Morales-Mantilla,Katherine Y King
Daniel E Morales-Mantilla
Purpose of review: Interferon-gamma (IFN-γ) is a pro-inflammatory cytokine that participates in the regulation of hematopoietic stem cells (HSC) during development and under homeostatic conditions. IFN-γ also plays a ke...
Sarah Chan
Sarah Chan
Purpose of review: The '14-day rule', which limits research on human embryos to the first 14 days after fertilisation, has long been a pillar of regulation in this contested area. Recently, advances in developmental biolo...
Epigenetic and Epitranscriptomic Factors Make a Mark on Hematopoietic Stem Cell Development [0.03%]
表观遗传和表转录组因素在造血干细胞发育中的作用不容小觑
Dionna M Kasper,Stefania Nicoli
Dionna M Kasper
Purpose of the review: Blood specification is a highly dynamic process, whereby committed hemogenic endothelial cells (ECs) progressively transdifferentiate into multipotent, self-renewing hematopoietic stem cells (HSCs)....
The Role of Steroid Hormones in Breast and Effects on Cancer Stem Cells [0.03%]
类固醇激素在乳腺中的作用及其对癌干细胞的影响
Denis G Alferez,Bruno M Simões,Sacha J Howell et al.
Denis G Alferez et al.
Purpose of review: This review will discuss how the steroid hormones, estrogen and progesterone, as well as treatments that target steroid receptors, can regulate cancer stem cell (CSC) activity. The CSC theory proposes a...