Rita Matta,Anjelica L Gonzalez
Rita Matta
Purpose of review: Neural stem cells (NSCs) have the potential to proliferate and differentiate into functional neurons, heightening their potential use for therapeutic applications. This review explores bioengineered sys...
Bryan Cwik
Bryan Cwik
Purpose of review: Continued development of gene editing techniques has raised the real possibility of clinical application of germline gene editing. These results, as well as reports of an unethical experiment which resu...
Common Sources of Inflammation and Their Impact on Hematopoietic Stem Cell Biology [0.03%]
炎症的常见来源及其对造血干细胞生物学的影响
Daniel Hormaechea-Agulla,Duy T Le,Katherine Y King
Daniel Hormaechea-Agulla
Purpose of review: Inflammatory signals have emerged as critical regulators of hematopoietic stem cell (HSC) function. Specifically, HSCs are highly responsive to acute changes in systemic inflammation and this influences...
Paradigms that define lung epithelial progenitor cell fate in development and regeneration [0.03%]
定义发育和再生过程中肺上皮干细胞命运的理论模型
Aravind Sivakumar,David B Frank
Aravind Sivakumar
Purpose of review: Throughout the lifespan, lung injury impedes the primary critical function essential for life-respiration. To repair quickly and efficiently is critical and is orchestrated by a diverse repertoire of pr...
Mechanistic Insights into Factor VIII Immune Tolerance Induction via Prenatal Cell Therapy in Hemophilia A [0.03%]
血友病A孕前细胞治疗中 factor VIII 免疫耐受诱导的机制研究
Martin Rodriguez,Christopher D Porada,Graҫa Almeida-Porada
Martin Rodriguez
Purpose of review: Prenatal stem cell and gene therapy approaches are amongst the few therapies that can promise the birth of a healthy infant with specific known genetic diseases. This review describes fetal immune cell ...
Signaling Pathways Regulating Hematopoietic Stem Cell and Progenitor Aging [0.03%]
调控造血干细胞和祖细胞衰老的信号通路
Abhishek K Singh,Mark J Althoff,Jose A Cancelas
Abhishek K Singh
Purpose of review: Functional decline of hematopoiesis that occurs in the elderly, or in patients who receive therapies that trigger cellular senescence effects, results in a progressive reduction in the immune response a...
Correction to: The Role of Intestinal Stem Cells in Epithelial Regeneration Following Radiation-Induced Gut Injury [0.03%]
Correction to: 辐射所致肠道损伤后的上皮再生的肠道干细胞的作用
Chang-Kyung Kim,Vincent W Yang,Agnieszka B Bialkowska
Chang-Kyung Kim
[This corrects the article DOI: 10.1007/s40778-017-0103-7.].
Published Erratum
Current stem cell reports. 2018;4(1):95. DOI:10.1007/s40778-018-0121-0 2018
Xinxin Huang,Thao Trinh,Arafat Aljoufi et al.
Xinxin Huang et al.
Purpose of review: This review summarizes the role of hypoxia and hypoxia-inducible factors (HIFs) in the regulation of stem cell biology, specifically focusing on maintenance, differentiation, and stress responses in the...
Louis M Pelus,Hal E Broxmeyer
Louis M Pelus
The purpose of review: Mobilized peripheral blood is the predominant source of stem and progenitor cells for hematologic transplantation. Successful transplant requires sufficient stem cells of high enough quality to reca...
Margot May,Anastasiya Slaughter,Daniel Lucas
Margot May
Purpose of review: Hematopoietic stem cells (HSC) reside in a specialized microenvironment called the HSC niche. While key components of the niche have been known for several years, recent advances have identified several...