Preclinical Studies and Clinical Prospects of Wharton's Jelly-Derived MSC for Treatment of Acute Radiation Syndrome [0.03%]
威豪氏胶来源的间充质干细胞治疗放射病的临床前研究及临床应用前景
Mayuri Bandekar,Dharmendra K Maurya,Deepak Sharma et al.
Mayuri Bandekar et al.
Purpose of review: Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) have received widespread attention from researchers owing to the remarkable benefits offered by these cells over other stem cells. The primitive ...
Integration of mechanical and ECM microenvironment signals in the determination of cancer stem cell states [0.03%]
机械信号和细胞外基质微环境信号在决定癌干细胞状态中的整合作用分析
Tiina A Jokela,Mark A LaBarge
Tiina A Jokela
Purpose of review: Cancer stem cells (CSCs) are increasingly understood to play a central role in tumor progression. Growing evidence implicates tumor microenvironments as a source of signals that regulate or even impose ...
The role of RNA epigenetic modification in normal and malignant hematopoiesis [0.03%]
RNA表观遗传修饰在正常和恶性造血中的作用
Radovan Vasic,Yimeng Gao,Chengyang Liu et al.
Radovan Vasic et al.
Purpose of review: RNA epigenetic modifications have been identified as novel, dynamic regulators of gene expression, with important impacts on stem cell fate decisions. Here we examine the functions of RNA modifications,...
Marine Barthez,Zehan Song,Chih Ling Wang et al.
Marine Barthez et al.
Purpose of review: Diet has profound impacts on health and longevity. Evidence is emerging to suggest that diet impinges upon the metabolic pathways in tissue-specific stem cells to influence health and disease. Here, we ...
Virus-specific T cells for malignancies - then, now and where to? [0.03%]
针对病毒的特异性T细胞与肿瘤免疫治疗：过去、现在和将来
Sandhya Sharma,Wingchi K Leung,Helen E Heslop
Sandhya Sharma
Purpose of review: Virus-associated malignancies are a global health burden, constituting 10-12% of cancers worldwide. As these tumors express foreign viral antigens that can elicit specific T cell responses, virus-direct...
Hurdles Associated with the Translational Use of Genetically Modified Cells [0.03%]
基因修饰细胞转化应用遇到的障碍问题分析
Sunil S Raikar,H Trent Spencer
Sunil S Raikar
Purpose of review: Recent advancements in the use of genetically modified hematopoietic stem cells (HSCs) and the emergent use of chimeric antigen receptor (CAR) T-cell immunotherapy has highlighted issues associated with...
Arun Pradhan,Tanya V Kalin,Vladimir V Kalinichenko
Arun Pradhan
Purpose of the review: Significant numbers of patients worldwide are affected by various rare diseases, but the effective treatment options to these individuals are limited. Rare diseases remain underfunded compared to mo...
Paulina D Horton,Sandeep Dumbali,Pamela L Wenzel
Paulina D Horton
Purpose of review: Hematopoietic stem cells (HSCs) are reliant on intrinsic and extrinsic factors for tight control of self-renewal, quiescence, differentiation, and homing. Given the intimate relationship between HSCs an...
Bioartificial Kidneys [0.03%]
生物人工肾脏
Peter R Corridon,In Kap Ko,James J Yoo et al.
Peter R Corridon et al.
Purpose of review: Historically, there have been many advances in the ways in which we treat kidney diseases. In particular, hemodialysis has set the standard for treatment since the early 1960s and continues today as the...
Use of MSCs and MSC-educated macrophages to mitigate hematopoietic acute radiation syndrome [0.03%]
使用间充质干细胞和经间充质干细胞教育过的巨噬细胞以减轻血液造血急性辐射综合征
Raghavan Chinnadurai,Matthew H Forsberg,John A Kink et al.
Raghavan Chinnadurai et al.
Purpose of review: Innovative and minimally toxic treatment approaches are sorely needed for the prevention and treatment of hematopoietic acute radiation syndrome (H-ARS). Cell therapies have been increasingly studied fo...