Abraham P Lee,Mohammad Aghaamoo,Tayloria N G Adams et al.
Abraham P Lee et al.
Purpose of review: Advanced technologies can aid discoveries in stem cell science in surprising ways. The application of electrokinetic techniques, which use electric fields to interrogate or separate cells, to the study ...
Cytokinetic Abscission Regulation in Neural Stem Cells and Tissue Development [0.03%]
神经干细胞和组织发育中的细胞分裂脱落调控机制
Katrina C McNeely,Noelle D Dwyer
Katrina C McNeely
Purpose of review: How stem cells balance proliferation with differentiation, giving rise to specific daughter cells during development to build an embryo or tissue, remains an open question. Here, we discuss recent evide...
Impact of Cryopreservation and Freeze-Thawing on Therapeutic Properties of Mesenchymal Stromal/Stem Cells and Other Common Cellular Therapeutics [0.03%]
cryopreservation和冻融对间充质基质/干细胞及其他常见细胞治疗产品疗效属性的影响
Chasen Cottle,Amanda Paige Porter,Ariel Lipat et al.
Chasen Cottle et al.
Purpose of review: Cryopreservation and its associated freezing and thawing procedures-short "freeze-thawing"-are among the final steps in economically viable manufacturing and clinical application of diverse cellular the...
Vinothini Govindarajah,Damien Reynaud
Vinothini Govindarajah
Purpose of review: Immunological memory is an important evolutionary adaptation of the immune system. Previously restricted to the adaptive immune system, the concept of memory has recently been broadened to the innate im...
Andrea Keller,Tyus Temple,Behnam Sayanjali et al.
Andrea Keller et al.
Purpose of review: From invertebrates to vertebrates, the ability to sense nutrient availability is critical for survival. Complex organisms have evolved numerous signaling pathways to sense nutrients and dietary fluctuat...
Sensing Stemness [0.03%]
感应多潜能性
Teresa V Bowman,Eirini Trompouki
Teresa V Bowman
Purpose of review: Hematopoietic stem cells (HSCs) are formed embryonically during a dynamic developmental process and later reside in adult hematopoietic organs in a quiescent state. In response to their changing environ...
Vascular Regulation of Hematopoietic Stem Cell Homeostasis, Regeneration, and Aging [0.03%]
血管对造血干细胞自稳态、再生及衰老的调节
Pradeep Ramalingam,Jason M Butler,Michael G Poulos
Pradeep Ramalingam
Purpose of review: Hematopoietic stem cells (HSCs) sit at the top of the hierarchy that meets the daily burden of blood production. HSC maintenance relies on extrinsic cues from the bone marrow (BM) microenvironment to ba...
Cellular Complexity of Hemochorial Placenta: Stem Cell Populations, Insights from scRNA-seq, and SARS-CoV-2 Susceptibility [0.03%]
血液绒毛膜胎盘的细胞复杂性：干细胞群，单细胞RNA序列的见解以及SARS-CoV-2的易感性
Christopher S Mallery Jr,Maira Carrillo,Ariel Mei et al.
Christopher S Mallery Jr et al.
Purpose of review: The placenta is a transient organ that forms de novo and serves a critical role in supporting fetal growth and development. Placental oxygen, nutrients, and waste are transported through processes that ...
Regulatory Framework for Academic Investigator-Sponsored Investigational New Drug Development of Cell and Gene Therapies in the USA [0.03%]
美国学术研究者发起的细胞和基因治疗新药研究的监管框架
Anindya Dasgupta,Kristen Herzegh,H Trent Spencer et al.
Anindya Dasgupta et al.
Purpose of review: The promise of cell and gene therapy (CGT) products for a multitude of diseases has revitalized investigators to advance novel CGT product candidates to first-in-human trials by pursuing the investigati...
Targeting the aryl hydrocarbon receptor in stem cells to improve the use of food as medicine [0.03%]
靶向干细胞中的芳香烃受体以提高食物的药用价值
Huajun Han,Arul Jayaraman,Stephen Safe et al.
Huajun Han et al.
Purpose of review: Intestinal stem cells, the most rapidly proliferating adult stem cells, are exquisitely sensitive to extrinsic dietary factors. Uncontrolled regulation of intestinal stem cells is closely linked to colo...