Efraín A Cermeño,Andrés J García
Efraín A Cermeño
The discovery and subsequent isolation of tumor-initiating cells (TICs), a small population of highly tumorigenic and drug-resistant cancer cells also called cancer stem cells (CSCs), have revolutionized our understanding of cancer. TICs ar...
Challenges and Opportunities to Harnessing the (Hematopoietic) Stem Cell Niche [0.03%]
利用（造血）干细胞生态位的挑战与机遇
Ji Sun Choi,Brendan A C Harley
Ji Sun Choi
In our body, stem cells reside in a microenvironment termed the niche. While the exact composition and therefore the level of complexity of a stem cell niche can vary significantly tissue-to-tissue, the stem cell niche microenvironment is d...
Platelet-Rich Blood Derivatives for Stem Cell-Based Tissue Engineering and Regeneration [0.03%]
基于干细胞的组织工程和再生的富血小板血液衍生物
Elham Masoudi,João Ribas,Gaurav Kaushik et al.
Elham Masoudi et al.
Platelet rich blood derivatives have been widely used in different fields of medicine and stem cell based tissue engineering. They represent natural cocktails of autologous growth factor, which could provide an alternative for recombinant p...
Antonio Pierini,Dominik Schneidawind,Hidekazu Nishikii et al.
Antonio Pierini et al.
Broad clinical interest rapidly followed the recent discovery of different subpopulations of T cells that have immune regulatory properties and a number of studies have been conducted aiming to dissect the translational potential of these p...
David E Muench,H Leighton Grimes
David E Muench
Hematopoiesis is characterized by a lifelong balance between hematopoietic stem cell (HSC) self-renewal and differentiation into mature blood populations. Proper instruction of cell fate decisions requires tight homeostatic regulation of tr...
Jacqueline Barry,Johan Hyllner,Glyn Stacey et al.
Jacqueline Barry et al.
The development of induced pluripotent stem cells offers the possibility of the scalable manufacture of cellular therapies for regenerative medicine. Moreover, donors can be selected on the basis of major transplant antigen systems to match...
Regenerating Retinal Pigment Epithelial Cells to Cure Blindness: A Road Towards Personalized Artificial Tissue [0.03%]
视网膜色素上皮细胞再生治盲研究——朝向个性化人工组织之路
Balendu Shekhar Jha,Kapil Bharti
Balendu Shekhar Jha
Retinal pigment epithelium (RPE) is a polarized monolayer tissue that functions to support the health and integrity of retinal photoreceptors (PRs). RPE atrophy has been linked to pathogenesis of age-related macular degeneration (AMD), a le...
Matthew H Porteus
Matthew H Porteus
The ability to remove blood cells, including hematopoietic stem cells (HSCs), from a person and then re-transplant them (hematopoietic stem cell transplantation (HSCT) is a well-established treatment paradigm that can be used in both the au...