Gautham Gampa,Shruthi Vaidhyanathan,Brynna-Wilken Resman et al.
Gautham Gampa et al.
Brain metastases are a major cause of morbidity and mortality in patients with advanced melanoma. Recent approval of several molecularly-targeted agents and biologics has brought hope to patients with this previously untreatable disease. Ho...
New Pharmacological Approaches to Treating Non-Motor Symptoms of Parkinson's Disease [0.03%]
治疗帕金森病非运动症状的新型药理学方法
Michael A Kelberman,Elena M Vazey
Michael A Kelberman
Purpose of review: Non-motor symptoms in patients with Parkinson's Disease (PD) are better predictors of quality of life changes, caregiver burden, and mortality than motor symptoms. Levodopa has limited, and sometimes de...
Impact of Drug Treatment at Neonatal Ages on Variability of Drug Metabolism and Drug-drug Interactions in Adult Life [0.03%]
新生儿期药物治疗对成人期药物代谢个体差异和药物相互作用的影响
Stephanie Piekos,Chad Pope,Austin Ferrara et al.
Stephanie Piekos et al.
Purpose of review: As the number of patients taking more than one medication concurrently continues to increase, predicting and preventing drug-drug interactions (DDIs) is now more important than ever. Administration of o...
Progress in Prediction and Interpretation of Clinically Relevant Metabolic Drug-Drug Interactions: a Minireview Illustrating Recent Developments and Current Opportunities [0.03%]
临床相关代谢型药物相互作用的预测与诠释进展：近期研究动态及当前机遇综述
Stephen Fowler,Peter N Morcos,Yumi Cleary et al.
Stephen Fowler et al.
Purpose of review: This review gives a perspective on the current "state of the art" in metabolic drug-drug interaction (DDI) prediction. We highlight areas of successful prediction and illustrate progress in areas where ...
Obeid M Malekshah,Xuguang Chen,Alireza Nomani et al.
Obeid M Malekshah et al.
The use of enzyme/prodrug system has gained attention because it could help improve the efficacy and safety of conventional cancer chemotherapies. In this approach, cancer cells are first transfected with a gene that can express an enzyme w...
The Role of Interaction Model in Simulation of Drug Interactions and QT Prolongation [0.03%]
药物相互作用及QT间期延长模拟中交互模型的作用
Barbara Wiśniowska,Sebastian Polak
Barbara Wiśniowska
Computational modelling is a cornerstone of Comprehensive In Vitro Proarrhythmia Assay and is re-increasingly being used in drug development. Electrophysiological effects of drug-drug interactions can be predicted in silico, e.g. with the u...
Shiv Ram Krishn,Surinder K Batra,Sukhwinder Kaur
Shiv Ram Krishn
MicroRNAs (miRNAs) are an important class of small non-coding RNAs that direct post-transcriptional gene regulation by different mechanisms. Mounting evidences from numerous studies in the last decade have unraveled that deregulated miRNAs,...
A Molecular Aspect in the Regulation of Drug Metabolism: Does PXR-Induced Enzyme Expression Always Lead to Functional Changes in Drug Metabolism? [0.03%]
核受体PXR诱导的酶表达与药物代谢表型改变之间的关系：一些值得思考的问题
Yuan Wei,Chenxiao Tang,Vinayak Sant et al.
Yuan Wei et al.
Pregnane X receptor (PXR, NR112) is a xenobiotic receptor whose primary function is to regulate the expression of drug-metabolizing enzymes (DMEs) and drug transporters. Drug-induced PXR activation and subsequent enzyme and transporter indu...
Bioinformatic Analysis of DNA Methylation in Neural Progenitor Cell Models of Alcohol Abuse [0.03%]
酒精滥用神经祖细胞模型的DNA甲基化 bioinformatics分析
Eileen N Oni,Ronald P Hart
Eileen N Oni
Several recent publications sought to investigate the effects of ethanol treatment on models of central nervous system development, specifically through changes in DNA methylation. Regulation of DNA methylation causes a long-lasting, epigen...
A Critical Review of Methodologies to Detect Reactive Oxygen and Nitrogen Species Stimulated by NADPH Oxidase Enzymes: Implications in Pesticide Toxicity [0.03%]
检测由NADPH氧化酶激活的反应性氧和氮物质的方法学批判性评述：对农药毒理学的意义
Balaraman Kalyanaraman,Micael Hardy,Jacek Zielonka
Balaraman Kalyanaraman
In this review, potential fluorescent probe applications for detecting reactive oxygen and nitrogen species (ROS/RNS) generated from NADPH oxidases (e.g., Nox2) and nitric oxide synthase enzymes are discussed in the context of pesticide tox...