Saurav Doshi,Christina Glytsou
Saurav Doshi
Purpose of review: This article outlines the role of mitochondrial dynamics in healthy cells and elaborates on how blood cancer cells hijack these processes to support uncontrolled proliferation, stemness, and drug resist...
Application of Physiologically-Based Pharmacokinetic (PBPK) Model in Drug Development and in Dietary Phytochemicals [0.03%]
生理药动学（PBPK）模型在药物研发和膳食植物化学成分研究中的应用
PoChung Chou,Ahmad Shannar,Yuxin Pan et al.
PoChung Chou et al.
Purpose of review: Physiologically-based pharmacokinetic (PBPK) modeling is a powerful tool to understand drug movements throughout the human body. Unlike classical PK methods that often lack sufficient physiological deta...
Feasibility and Safety of Targeting Mitochondria Function and Metabolism in Acute Myeloid Leukemia [0.03%]
靶向急性髓系白血病线粒体功能和代谢的可行性和安全性
Patryk Firmanty,Monika Chomczyk,Shubhankar Dash et al.
Patryk Firmanty et al.
Purpose of review: Acute myeloid leukemia (AML) is a clonal blood neoplasm with dismal prognosis. Despite the introduction of many novel targeted agents, cytotoxic chemotherapy has remained the standard of care for AML. D...
Exploring the Epigenetic and Metabolic Pathways for Antioxidant and Anti-Inflammatory Potentials of Tart Cherry Juice Concentrate [0.03%]
探究浓缩蔓越莓汁抗氧化和抗炎的表观遗传和代谢途径
Jiawei Xu,Yuxin Pan,Rebecca Mary Peter et al.
Jiawei Xu et al.
Tart cherry (TC; Prunus cerasus) has high antioxidant and anti-inflammatory potentials due to its rich bioactive components like anthocyanins, polyphenols, vitamins, beta-carotene, ellagic acid, and chlorogenic acid. Oxidative damage and in...
Rapid diagnostics to enhance therapy selection for the treatment of bacterial infections [0.03%]
快速诊断以提高治疗细菌感染的疗法选择效果
HaYoung Ryu,Ahmed Abdul Azim,Pinki J Bhatt et al.
HaYoung Ryu et al.
Purpose of review: Rapid diagnostic tests (RDTs) may reduce morbidity and mortality related to bacterial infections by reducing time to identification of pathogens and antibiotic resistance mechanisms. There has been a si...
Application of Metabolomics in Carcinogenesis and Cancer Prevention by Dietary Phytochemicals [0.03%]
饮食植物化学物在癌症发生及癌症预防中的代谢组学应用研究
Rebecca Mary Peter,Xiaoyang Su,Ah-Ng Kong
Rebecca Mary Peter
Purpose of review: In this review article, specific emphasis is on evolution of metabolomics in cancer research, metabolomics workflow, general understanding of liquid chromatography - mass spectrometry (LC-MS) based plat...
Pharmacodynamics (PD), Pharmacokinetics (PK) and PK-PD Modeling of NRF2 Activating Dietary Phytochemicals in Cancer Prevention and in Health [0.03%]
NRF2激活的植物化学物质在癌症预防和健康中的药效学(PD)，药代动力学(PK)及PK-PD建模研究
Ahmad Shannar,Pochung Jordan Chou,Rebecca Peter et al.
Ahmad Shannar et al.
Purpose of review: Dietary phytochemicals, bioactive compounds derived from plants, have gained increasing attention for their potential role in cancer prevention. Among these, NRF2 (nuclear factor erythroid 2-related fac...
Wnt Signaling and Therapeutic Resistance in Castration-Resistant Prostate Cancer [0.03%]
雄激素剥夺治疗耐药性前列腺癌中的Wnt信号与治疗抗性问题研究
Chandra Kishore,Xiaolin Zi
Chandra Kishore
Purpose of review: Castration-resistant prostate cancer (CRPC) is a lethal form of prostate cancer (PCa) due to the development of resistance to androgen deprivation therapy and anti-androgens. Here, we review the emergin...
Kingsley E W Walker,Reshma Bankay,Satish Jankie et al.
Kingsley E W Walker et al.
Purpose of overview: The constant surge in accessing essential medicines creates a greater need for continuous monitoring of usage. The inability to source active pharmaceutical ingredients during the COVID-19 pandemic re...
Samriddhi Ranjan,Kanupriya Vashishth,Katrin Sak et al.
Samriddhi Ranjan et al.
The world recently witnessed the emergence of new epidemic outbreaks like COVID-19 and mpox. The 2022 outbreak of mpox amid COVID-19 presents an intricate situation and requires strategies to combat the status quo. Some of the challenges to...