Jenna H Newman,Andrew Zloza
Jenna H Newman
Purpose of review: This article provides a brief overview of the role that infections play in cancer emergence and cancer treatment. Recent findings: ...
Sphingosine Kinases/Sphingosine 1-Phosphate Signaling in Hepatic Lipid Metabolism [0.03%]
鞘氨醇激酶/鞘氨醇1-磷酸在肝脏脂质代谢中的作用
Eric K Kwong,Xiaojiaoyang Li,Phillip B Hylemon et al.
Eric K Kwong et al.
The ever-increasing prevalence of metabolic diseases such as dyslipidemia and diabetes in the western world continues to be of great public health concern. Biologically active sphingolipids, such as sphingosine 1-phosphate (S1P) and ceramid...
Reactive Carbonyl Species Scavengers-Novel Therapeutic Approaches for Chronic Diseases [0.03%]
反应性羰基化合物清除剂：慢性疾病治疗的新思路
Sean S Davies,Linda S Zhang
Sean S Davies
Purpose of the review: To summarize recent evidence supporting the use of reactive carbonyl species scavengers in the prevention and treatment of disease. ...
Remote Sensing between Liver and Intestine: Importance of Microbial Metabolites [0.03%]
肝肠轴的远程调控：微生物代谢物的重要性
Zidong Donna Fu,Julia Yue Cui
Zidong Donna Fu
Recent technological advancements including metagenomics sequencing and metabolomics have allowed the discovery of critical functions of gut microbiota in obesity, malnutrition, neurological disorders, asthma, and xenobiotic metabolism. Cla...
Role of FXR in Liver Inflammation during Nonalcoholic Steatohepatitis [0.03%]
FXR在非酒精性 steatohepatitis肝炎炎症中的作用
Laura E Armstrong,Grace L Guo
Laura E Armstrong
Purpose of review: About 15-25% of patients with simple steatosis of non-alcoholic fatty liver disease progresses to non-alcoholic steatohepatitis (NASH), and the underlying mechanism for this progression has not been elu...
Challenges and Opportunities with Predicting in Vivo Phase II Metabolism via Glucuronidation from in Vitro Data [0.03%]
体外数据预测体内II相葡糖醛酸结合代谢的挑战和机遇
Shufan Ge,Yifan Tu,Ming Hu
Shufan Ge
Glucuronidation is the most important phase II metabolic pathway which is responsible for the clearance of many endogenous and exogenous compounds. To better understand the elimination process for compounds undergoing glucuronidation and id...
Sarah F Cook,Robert R Bies
Sarah F Cook
Disease modeling involves the use of mathematical functions to describe quantitatively the time course of disease progression. In order to characterize the natural progression of disease, these models generally incorporate longitudinal data...
Pengcheng Wang,Amina I Shehu,Xiaochao Ma
Pengcheng Wang
Although safety of drug candidates is carefully monitored in preclinical and clinical studies using a variety of approaches, drug toxicity may still occur in clinical practice. Therefore, novel approaches are needed to complement the curren...
Single-Cell Transcriptome Analysis of Developing and Regenerating Spiral Ganglion Neurons [0.03%]
单细胞转录组揭示耳蜗神经元的发育和再生机制
Kelvin Y Kwan
Kelvin Y Kwan
The spiral ganglion neurons (SGNs) of the cochlea are essential for our ability to hear. SGN loss after exposure to ototoxic drugs or loud noise results in hearing loss. Pluripotent stem cell-derived and endogenous progenitor cell types hav...
Environmental influences in the etiology of colorectal cancer: the premise of metabolomics [0.03%]
环境因素在结直肠癌病因学中的作用：代谢组学的理论基础
Nicholas J W Rattray,Georgia Charkoftaki,Zahra Rattray et al.
Nicholas J W Rattray et al.
Purpose of review: In this review we discuss how environmental exposures predominate the etiology of colorectal cancer (CRC). With CRC being a personalized disease influenced by genes and environment, our goal was to expl...