Pharmacometric Applications and Challenges in the Development of Therapeutic Antibodies in Immuno-Oncology [0.03%]
免疫肿瘤学中治疗性抗体开发中的药代动力学应用与挑战
Lei Diao,Bernd Meibohm
Lei Diao
Purpose of review: Monoclonal antibodies targeting key checkpoints in immune stimulatory pathways have over the last years become the mainstay of cancer immunotherapy. This article provides a brief review of the applicati...
Yi Ching Esther Wan,Jiaxian Liu,Kui Ming Chan
Yi Ching Esther Wan
Histone modifications are one form of epigenetic information that relate closely to gene regulation. Aberrant histone methylation caused by alteration in chromatin-modifying enzymes has long been implicated in cancers. More recently, recurr...
Ying Li,Jeremy Anderson,Kelvin Y Kwan et al.
Ying Li et al.
Neural stem cells (NSCs) in the adult central nervous system play essential roles in both normal homeostasis and repair of damaged tissue after injury. The study of adult NSCs is hampered by the heterogeneous NSC population. In this review,...
Almin I Lalani,Sining Zhu,Samantha Gokhale et al.
Almin I Lalani et al.
Purpose of review: This review presents an overview of the current knowledge of TRAF molecules in inflammation with an emphasis on available human evidence and direct in vivo evidence of mouse models that demonstrate the ...
Ju Hwan Cho,Filiz Oezkan,Michael Koenig et al.
Ju Hwan Cho et al.
Lung cancer is the leading cause of cancer-related death in the United States and worldwide. Novel therapeutic developments are critically necessary to improve outcomes for this disease. Aberrant epigenetic change plays an important role in...
Host response to pulmonary fungal infections: A highlight on cell-driven immunity to Cryptococcus species and Aspergillus fumigatus [0.03%]
肺部真菌感染的宿主反应：念珠菌属和烟曲霉细胞免疫研究进展概要
Orchi Dutta,Jorge A Masso-Silva,Keyi Wang et al.
Orchi Dutta et al.
Amanda R Muñoz,Divya Chakravarthy,Jingjing Gong et al.
Amanda R Muñoz et al.
Purpose of the review: The 5-year survival rate of patients with pancreatic cancer (PanCA) has remained stagnant. Unfortunately, the incidence is almost equal to mortality rates. These facts underscore the importance of c...
Eswar Shankar,Aditi Goel,Karishma Gupta et al.
Eswar Shankar et al.
Research in cancer chemoprevention provides convincing evidence that increased intake of vegetables and fruits may reduce the risk of several human malignancies. Phytochemicals present therein provide beneficial anti-inflammatory and antiox...
Type 2 cytokine responses: regulating immunity to helminth parasites and allergic inflammation [0.03%]
2型细胞因子反应：调节寄生虫免疫和过敏炎症
Everett K Henry,Juan M Inclan-Rico,Mark C Siracusa
Everett K Henry
Purpose of review: It is well established that T helper type 2 (TH2) immune responses are necessary to provide protection against helminth parasites but also to promote the detrimental inflammation associated with allergi...
Sentinels at the frontline: the role of intraepithelial lymphocytes in inflammatory bowel disease [0.03%]
前沿哨兵：上皮内淋巴细胞在炎症性肠病中的作用
Madeleine D Hu,Karen L Edelblum
Madeleine D Hu
Purpose of review: Intestinal mucosal immunity is tightly regulated to ensure effective host defense against invasive microorganisms while limiting the potential for aberrant damage. In inflammatory bowel disease (IBD), a...