Pipeline Pharmacological Therapies in Clinical Trial for COVID-19 Pandemic: a Recent Update [0.03%]
COVID-19大流行中临床试验的管线药理疗法：最新综述
Puja Kumari,Kajal Rawat,Lekha Saha
Puja Kumari
The emergence of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), responsible for causing coronavirus disease 2019 (COVID-19), marked the third time in the twenty-first century when a new, highly pathogenic human coronaviru...
Naomi Schlesinger,Bonnie L Firestein,Luigi Brunetti
Naomi Schlesinger
Purpose of review: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, is a pandemic causing havoc globally. Currently, there are no Food and Drug Adminis...
Simulation as a Tool to Illustrate Clinical Pharmacology Concepts to Healthcare Program Learners [0.03%]
使用模拟作为向医疗项目学习者展示临床药理学概念的工具
Liza Barbarello Andrews,Les Barta
Liza Barbarello Andrews
Purpose of review: This article provides an overview of simulation as an effective and evolving tool for teaching clinical pharmacology within the health professions. Further, opportunities for positioning this methodolog...
Linzi Fan,Shuang Jiang,Xinrong Yang et al.
Linzi Fan et al.
Purpose of review: An unprecedented outbreak of the novel coronavirus in China (COVID-19) occurred in December 2019, and then engulfed the entire world, presenting a significant and urgent threat to global health. Many re...
Utilization of Physiologically Based Pharmacokinetic Modeling in Clinical Pharmacology and Therapeutics: an Overview [0.03%]
生理药动学模型在临床药理与治疗中的应用概览
Courtney Perry,Grace Davis,Todd M Conner et al.
Courtney Perry et al.
The purpose of this review was to assess the advancement of applications for physiologically based pharmacokinetic (PBPK) modeling in various therapeutic areas. We conducted a PubMed search, and 166 articles published between 2012 and 2018 ...
Ah-Ng Kong,Andy T Y Lau,Luigi Brunetti
Ah-Ng Kong
The recent pandemic outbreak of COVID-19 (severe acute respiratory syndrome coronavirus 2; SARS-CoV-2) worldwide caught the health care systems in every country around the world by storm and without a proper defense mechanism to cope and co...
Renyi Wu,Lujing Wang,Hsiao-Chen Dina Kuo et al.
Renyi Wu et al.
The current pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has presented unprecedented challenges to the healthcare systems in almost every country around the world. Cu...
Ellagic Acid, Kaempferol, and Quercetin from Acacia nilotica: Promising Combined Drug With Multiple Mechanisms of Action [0.03%]
埃塞酸、山奈酚和杨梅素：来自Acacia nilotica的具有多种作用机制的有前景的联合药物
Mosab Yahya Al-Nour,Musab Mohamed Ibrahim,Tilal Elsaman
Mosab Yahya Al-Nour
The pharmacological activity of Acacia nilotica's phytochemical constituents was confirmed with evidence-based studies, but the determination of exact targets that they bind and the mechanism of action were not done; consequently, we aim to...
Ann M Bode,Zigang Dong
Ann M Bode
Cancer is still a major health issue worldwide and identifying novel but safe compounds for prevention and treatment is a high priority. Licorice (Glycyrrhiza) is a perennial plant that is cultivated in many countries and has been reported ...
Michael Coryell,Barbara A Roggenbeck,Seth T Walk
Michael Coryell
Purpose of review: Arsenic exposure is a public health concern of global proportions with a high degree of interindividual variability in pathologic outcomes. Arsenic metabolism is a key factor underlying toxicity, and th...