Lei Wang,James T F Wise,Zhuo Zhang et al.
Lei Wang et al.
Carcinogenesis induced by environmental metal exposure is a major public health concern. The exact mechanisms underlying metal carcinogenesis remain elusive. In the past few decades, the relationship between metal induced generation of reac...
Ioannis P Androulakis
Ioannis P Androulakis
Quantitative Systems Pharmacology (QSP) is receiving increased attention. As the momentum builds and the expectations grow it is important to (re)assess and formalize the basic concepts and approaches. In this short review, I argue that QSP...
Convergence of Highly Resolved and Rapid Screening Platforms with Dynamically Engineered, Cell Phenotype-Prescriptive Biomaterials [0.03%]
高通量筛选平台与动态工程细胞表型材料的收敛性研究
Neal K Bennett,Anandika Dhaliwal,Prabhas V Moghe
Neal K Bennett
Biophysical and biochemical cues from the cellular microenvironment initiate intracellular signaling through cellular membrane receptors and trigger specific cell developmental programs. Extracellular substrates and matrix scaffolds enginee...
Ontology-based Vaccine and Drug Adverse Event Representation and Theory-guided Systematic Causal Network Analysis toward Integrative Pharmacovigilance Research [0.03%]
基于本体的疫苗和药物不良事件表示及理论引导的系统因果网络分析用于整合药物警戒研究
Yongqun He
Yongqun He
Compared with controlled terminologies (e.g., MedDRA, CTCAE, and WHO-ART), the community-based Ontology of AEs (OAE) has many advantages in adverse event (AE) classifications. The OAE-derived Ontology of Vaccine AEs (OVAE) and Ontology of D...
Top-down, Bottom-up and Middle-out Strategies for Drug Cardiac Safety Assessment via Modeling and Simulations [0.03%]
基于模型和模拟的药物心脏安全性评价的自上而下、自下而上及中间途径策略
Zofia Tylutki,Sebastian Polak,Barbara Wiśniowska
Zofia Tylutki
Cardiac safety is an issue causing early terminations at various stages of drug development. Efforts are put into the elimination of false negatives as well as false positives resulting from the current testing paradigm. In silico approache...
Montserrat Rojo de la Vega,Matthew Dodson,Christine Gross et al.
Montserrat Rojo de la Vega et al.
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are the clinical manifestations of severe lung damage and respiratory failure. Characterized by severe inflammation and compromised lung function, ALI/ARDS result in ver...
Jun He,Bing-Hua Jiang
Jun He
Since both reactive oxygen species (ROS) production and microRNAs expression signature have been associated with tumor development, progression, metastasis and therapeutic response, it is important to understand the crosstalk between ROS an...
Recent Advances in Development and Application of Physiologically-Based Pharmacokinetic (PBPK) Models: a Transition from Academic Curiosity to Regulatory Acceptance [0.03%]
基于生理的药代动力学（PBPK）模型的发展和应用新进展：从学术好奇到监管认可
Masoud Jamei
Masoud Jamei
There is a renewed surge of interest in applications of physiologically-based pharmacokinetic (PBPK) models by the pharmaceutical industry and regulatory agencies. Developing PBPK models within a systems pharmacology context allows separati...
Oxidative stress, epigenetics, and cancer stem cells in arsenic carcinogenesis and prevention [0.03%]
砷致癌与防治中的氧化应激、表观遗传和癌症干细胞
Lingzhi Li,Fei Chen
Lingzhi Li
The carcinogenic role of arsenic has been extensively studied for more than half century. How arsenic causes human cancer, however, remains to be fully elucidated. In this brief review, we focus our attentions on the most recent discoveries...
Natural Agents Used in Chemoprevention of Aerodigestive and GI Cancers [0.03%]
天然药物在气道消化系及胃肠癌症化学预防中的应用
Jay Morris,Yuan Fang,Keya De Mukhopdhyay et al.
Jay Morris et al.
Aerodigestive cancers are on an increasing level in both occurrence and mortality. A major cause in many of these cancers is disruption of the inflammatory pathway, leading to increased cell proliferation, and epigenetic silencing of normal...