PRMT3-Mediated H4R3me2a Promotes Primary Age-Related Tauopathy by Driving Tau Hyperphosphorylation in Neuron [0.03%]
组蛋白H4R3甲基化促进原发性年龄相关tau病理形成的分子机制研究
Haotian Liu,Xinnan Liu,Fengyuan Tian et al.
Haotian Liu et al.
Primary age-related tauopathy (PART) and Alzheimer's disease (AD) both exhibit 3R/4R hyperphosphorylated tau-positive neurofibrillary tangles (NFTs) within the hippocampal-entorhinal system. Notably, PART patients show a higher degree of ta...
Colorectal Cancer Cells-Derived Exosomal PIK3CA Mutation DNA Promotes Tumor Metastasis by Activating Fibroblast and Affecting Tumor Metastatic Microenvironment [0.03%]
结直肠癌细胞来源的携带PIK3CA突变的外泌体DNA通过激活成纤维细胞和影响肿瘤转移微环境促进肿瘤转移
Rui Wang,Wanming Li,Yuqiong Lv et al.
Rui Wang et al.
Exosomes participate in the formation of the tumor metastatic microenvironment (TME) by delivering tumor-specific substances. However, current studies mostly focus on exosomal RNA and proteins and lack an in-depth exploration of exosomal DN...
PP1A Modulates the Efficacy of Lenvatinib Plus ICIs Therapy by Inhibiting Ferroptosis in Hepatocellular Carcinoma [0.03%]
PP1A通过抑制铁死亡调节肝细胞癌LEN治疗的疗效
Jitong Zhou,Meng Gao,Shikun Zhang et al.
Jitong Zhou et al.
Advanced hepatocellular carcinoma (HCC) is characterized by poor prognosis, primarily due to limited therapeutic options and resistance to treatment. Although the combination of tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibi...
Virome and Experimental Analysis Reveal Tryptophan-Like Dissolved Organic Matter Contributes to the Persistence of Plant Viruses in River Water [0.03%]
病毒组和实验分析揭示了色氨酸样溶解性有机物有助于植物病毒在河水中的持续存在
Yujie Wang,Ming Chen,Liu Yang et al.
Yujie Wang et al.
Plant viruses are devastating plant pathogens, resulting in annual losses exceeding billions of dollars in global agriculture. Once outside their plant host and insect vectors, plant viruses encounter unfavorable environmental factors that ...
Nicola Manca,Alejandro E Plaza,Leonélio Cichetto et al.
Nicola Manca et al.
Suspended micro-structures made of epitaxial complex oxides rely on surface micro-machining processes based on sacrificial layers. These processes prevent to physically access the microstructures from both sides, as substantial part of the ...
Mercaptophenylboronic Acid-Mediated Nanozyme Immunochromatographic Assay for Simultaneous Detection of Respiratory Bacteria and Virus [0.03%]
基于巯基苯硼酸介导的纳米酶试纸条的同时检测呼吸道病原体细菌和病毒的新方法
Qing Yu,Jiaxuan Li,Shuai Zheng et al.
Qing Yu et al.
Rapid, sensitive, and accurate detection of respiratory pathogens is essential yet challenging. Here, this study presents a universal nanozyme immunochromatographic assay (ICA) that utilizes the broad binding capacity of 4-mercaptophenylbor...
Reversal of Stress-Induced PIEZO1 Elevation with Mechanically Adapted Epicardial Patch for Myocardial Infarction Treatment [0.03%]
用于心脏病治疗的适应机械刺激的外膜贴片逆转应力引起的PIEZO1升高
Yuwen Lu,Sibo Jiang,Ting Shen et al.
Yuwen Lu et al.
Elevated expression of the mechanosensitive ion channel PIEZO1 in response to abnormal mechanical stimuli is implicated in many diseases, including myocardial infarction (MI). However, no effective strategy is currently available to normali...
Facilitating crRNA Design by Integrating DNA Interaction Features of CRISPR-Cas12a System [0.03%]
整合DNA相互作用特征以简化CRISPR-Cas12a系统crRNA的设计
Zhihao Yao,Wanglu Li,Kaiyu He et al.
Zhihao Yao et al.
The CRISPR-Cas12a system has gained significant attention as a rapid nucleic acid diagnostic tool due to its crRNA-guided trans-cleavage activity. Accurately predicting the activity of different targets is significant to facilitate the crRN...
Bionic Artificial Leaves Based on AIE-Active Supramolecular Hydrogel for Efficient Photocatalysis [0.03%]
基于AIE活性超分子水凝胶的仿生人工树叶用于高效光催化
Rongbo Zhang,Xueqi Tian,Minzan Zuo et al.
Rongbo Zhang et al.
A novel hydrogel-based biomimetic artificial leaf is fabricated by integrating host-guest interactions with covalent bonding. Specifically, a water-soluble tetraphenylethylene-embedded pillar[5]arene (m-TPEWP5), which exhibits aggregation-i...