Lingxiao Luo,Minqi Yang,Zhihan Song et al.
Lingxiao Luo et al.
Polycomb group (PcG) complexes play a crucial role in the regulation of gene repression and in organizing the 3D conformation of chromatin. However, while Polycomb Repressive Complex (PRC) 2 mediated H3K27me3 clearly contributes to the form...
Guofei Hou,Shenglan Zhang,Cangsong Shen et al.
Guofei Hou et al.
GABAB receptor is a Class C G protein-coupled receptor (GPCR) for γ-aminobutyric acid (GABA), the principal inhibitory neurotransmitter. It forms an obligatory heterodimer consisting of two subunits, GB1 and GB2. Whether the activation mec...
Ultra-High Friction and Adhesion in Hydrogel Layer Driven by Wet-to-Dry Transition Dynamics [0.03%]
由湿变干动力学驱动的水凝胶层超高摩擦和黏附力
Chenxu Liu,Tianhui Sun,Wenqing Chen et al.
Chenxu Liu et al.
Hydrogels are well-known for their antifriction and lubricating properties, particularly in hydrated environments, where their water-rich polymer networks enable effective friction reduction. However, during the wet-to-dry transition, a cri...
Cryogel-Based Dendritic Cell Immunotherapy for Post-Surgical Breast Cancer Treatment [0.03%]
基于冷冻凝胶的树突状细胞免疫治疗术后乳腺癌
Lam-Duc-Huy Nguyen,Sheng-Liang Cheng,Yu-Ting Yen et al.
Lam-Duc-Huy Nguyen et al.
Triple-negative breast cancer (TNBC) is an aggressive malignancy with high mortality and limited treatment options. While surgical resection removes the primary tumor, it often fails to prevent recurrence or metastasis, and despite the prom...
Comparative Single-Cell Transcriptomic Landscape Reveals the Regulatory Mechanisms of Lactation during Selective Breeding in Asian Water Buffalo [0.03%]
单细胞转录组图谱比较揭示亚洲水牛选择育种过程中泌乳调控机制
Dongmei Dai,Jingfang Si,Li Jiang et al.
Dongmei Dai et al.
Characterizing the cell type-specific transcriptome is crucial for understanding the cellular and molecular regulatory mechanisms underlying adaptive evolution and complex phenotypes. Here, single-cell/nucleus RNA sequencing (sc/snRNA-seq) ...
Regulating a NaF-Rich SEI Layer for Dendrite-Free Sodium Metal Batteries Using Trifunctional Halogenated Covalent Organic Framework Separators [0.03%]
用于无枝晶钠金属电池的 trifunctional 卤化共价有机框架隔膜调节富NaF SEI层
Muhammad Ali,Hamid Hussain,Moazzam Ali et al.
Muhammad Ali et al.
Uncontrolled sodium-ion (Na+) transport, fragile solid electrolyte interphase (SEI) layers, in and sluggish Na+ desolvation using conventional separators drive dendrite growth, posing critical challenges to the development of sodium metal b...
Microenvironment Engineering Enables Broad Strategies for Lithium-Sulfur Batteries [0.03%]
微环境工程实现锂硫电池的普适性策略
Ranqi Li,Yingbo Xiao,Shaoming Huang
Ranqi Li
Lithium-sulfur batteries (LSBs) are regarded as one of the most promising next-generation energy storage technologies due to their high energy density, abundant resource availability, and environmental sustainability. However, significant c...
Zinc Alleviates Gut Barrier Dysfunction by Promoting the Methylation of AKT [0.03%]
锌通过促进AKT甲基化来缓解肠道屏障功能障碍
Chuanjiang Cai,Yining Zheng,Bo Sun et al.
Chuanjiang Cai et al.
Zinc plays a crucial role in the gut barrier function and are widely used for the prevention of bowel disease. However, the mechanism via which zinc supplementation exerts this regulatory effect is unclear. The present study identifies and ...
BInD: Bond and Interaction-Generating Diffusion Model for Multi-Objective Structure-Based Drug Design [0.03%]
基于结构的多目标药物设计的Bond和Interaction生成扩散模型(BInD)
Joongwon Lee,Wonho Zhung,Jisu Seo et al.
Joongwon Lee et al.
Recent remarkable advancements in geometric deep generative models, coupled with accumulated structural data, enable structure-based drug design (SBDD) using only target protein information. However, existing models often struggle to balanc...