ACSS2-Mediated Histone H4 Lysine 12 Crotonylation (H4K12cr) Alleviates Colitis via Enhancing Transcription of CLDN7 [0.03%]
ACSS2介导的组蛋白H4第12位赖氨酸克罗顿酸化通过增强CLDN7转录缓解结肠炎%H4K12cr通过增强cldn7转录缓解结肠炎的一种新机制：acss2介导的组蛋白h4第12位赖氨酸克罗顿酸化
Ming Yuan,Shaopeng Chen,Zhensen Lin et al.
Ming Yuan et al.
Histone lysine crotonylation (Kcr), a highly conserved posttranslational modification, plays critical roles in various biological processes. Nevertheless, the dynamic alterations and functions of histone Kcr in inflammatory bowel disease (I...
Divergent Delivery and Expression Kinetics of Lipid and Polymeric Nanoparticles across mRNA Modalities [0.03%]
脂质和聚合物纳米颗粒的递送和表达动力学的差异性及其在不同mRNA模态中的应用
Irafasha C Casmil,Josh J Friesen,Nuthan V Bathula et al.
Irafasha C Casmil et al.
Messenger ribonucleic acid (mRNA)-based therapies, including conventional linear mRNA (linRNA), circular RNA (circRNA), and self-amplifying RNA (saRNA), are being developed not only for vaccination but also for protein replacement, gene edi...
Advanced Cancer Immunotherapy via SMARCAL1 Blockade Using a Glucose-Responsive CRISPR Nanovaccine [0.03%]
一种基于葡萄糖响应型CRISPR纳米疫苗的SMARCAL1阻断 advanced 癌症免疫治疗
Yuwei Li,Yuanyi Zhang,Chenchen Li et al.
Yuwei Li et al.
Cancer immunotherapy that activates the stimulator of interferon genes (STING) signaling pathway to resist tumors has recently attracted considerable attention. However, STING activation can induce opposing interferon functions that contrib...
High-Sensitivity Perovskite γ-Ray Detectors Enhanced by Device Engineering Toward Energy Spectroscopy Imaging [0.03%]
高性能钙钛矿γ射线探测器及能量谱成像研究取得进展
Ken Qin,Jia-He Zhang,Ruo-Long Zhou et al.
Ken Qin et al.
Perovskite-based detectors for γ-rays have emerged relatively recently and have attracted limited attention. Although increasing efforts are being directed towards their development, the absence of an adaptive processor, systematic theoret...
EGR1 Promotes Craniofacial Bone Regeneration via Activation of ALPL⁺PDGFD⁺ Periosteal Stem Cells [0.03%]
EGR1通过激活ALPL⁺PDGFD⁺骨膜干细胞促进颅面骨再生
Yang Li,Dazhuang Lu,Fanqing Xu et al.
Yang Li et al.
Oral and craniofacial bone regeneration remains challenging due to unique anatomical and functional demands. Rodent models have limited translational value because of significant structural differences from humans. The study reveals high si...
Sparse Nanocrystals Enable Ultra-Low Coercivity and Remarkable Mechanical Robustness in High-Entropy Amorphous Alloy [0.03%]
稀纳米晶体使高熵非晶合金具有超低矫顽力和卓越的机械耐久性
Lichen Liu,Liliang Shao,Yan Ma et al.
Lichen Liu et al.
Ferromagnetic high-entropy alloys (HEAs) are known for their excellent mechanical properties, which are attributed to their abundant ordered structures. However, they often exhibit compromised soft magnetic properties, which restrict their ...
Multifunctional Chiral Halide Perovskites: Advancing Chiro-Optics, Chiro-Optoelectronics, and Spintronics [0.03%]
多功能手性卤化物钙钛矿：推进手性光学、手性光电子学和自旋电子学的发展
Qi Liu,Hui Ren,Qi Wei et al.
Qi Liu et al.
Chiral halide perovskites (CHPs) represent a revolutionary material class, integrating the exceptional optoelectronic properties of halide perovskites with chirality. This unique combination enables advanced functionalities in chiroptics, s...
Hypoglycemia Induces Diabetic Macrovascular Endothelial Dysfunction via Endothelial Cell PANoptosis, Macrophage Polarization, and VSMC Fibrosis [0.03%]
低血糖通过内皮细胞PANoptosis、巨噬细胞极化和血管平滑肌细胞纤维化诱导糖尿病大血管内皮功能障碍
Deyu Zuo,Yuce Peng,Guozhi Zhao et al.
Deyu Zuo et al.
Hypoglycemia is a commonly neglected complication in elderly diabetic patients, which can lead to cardiovascular events. Endothelial cell dysfunction is the primary inducer of cardiovascular events, and it is associated with hypoglycemia-tr...
Carbon-Coated Probiotics Restore Intestinal Homeostasis to Promote Damage Repair in Inflammatory Bowel Disease [0.03%]
涂层益生菌可通过调节肠道稳态促进炎症性肠病损伤修复
Xue Chen,Haiyan Guo,Yuhan Li et al.
Xue Chen et al.
Inflammatory bowel disease (IBD) is regarded as green cancer that seriously endangers human quality of life. Orally administered probiotic treatment has been regarded as a promising strategy for the adjunctive treatment of IBD. However, its...
Adipose Tissue Macrophages as Initiators of Exacerbated Periodontitis in Estrogen-Deficient Environments via the Amplifier Extracellular Vesicles [0.03%]
雌激素缺乏环境下脂肪组织巨噬细胞通过放大器胞外囊泡诱发加重的牙周炎作用机制研究
Danfeng Li,Tian Yang,Yuqian Li et al.
Danfeng Li et al.
Periodontitis in menopausal women tends to exacerbate, potentially resulting in tooth loss and increased risk of systemic diseases. The prior research demonstrates that pro-inflammatory changes in macrophages under estrogen deficiency exace...