Localized Delivery of the mRNAs Encoding CD47 Inhibitor and Interleukins 12, 15, and 21 Elicits Robust Antitumor Immunity [0.03%]
编码CD47抑制剂和白细胞介素12、15和21的mRNA局部递送诱导强大的抗肿瘤免疫反应
Tao Jiang,Shuaiyang Jing,Haojun Li et al.
Tao Jiang et al.
CD47 inhibitors have emerged as promising candidates in cancer immunotherapy by activating macrophage phagocytosis through CD47/SIRPα signal blockade and enhancing dendritic cell antigen presentation. However, their clinical efficacy remai...
Panagiotis Mougkogiannis,Andrew Adamatzky
Panagiotis Mougkogiannis
Proteinoids, or thermal proteinoids, are produced by heating amino-acids. When placed in water, proteinoids swell into microspheres which produce neuron-like spikes of electrical potential. This study combines proteinoid microspheres with E...
Rational Design of Advanced Functional Catalysts for Photo-Reforming Glucose into Bio-Derived Fuels and Chemicals [0.03%]
用于光解葡萄糖制备生物燃料和化学品的先进功能催化剂的理性设计
Qiong Yan,Yuyue Zhou,Yan Zhang et al.
Qiong Yan et al.
Transforming renewable biomass resources into high-value chemicals and energy-dense fuels has become paramount for advancing sustainable economic development toward a carbon-neutral society. Glucose, a key platform molecule for biomass, has...
Damian Pociecha,Jadwiga Szydlowska,Nataša Vaupotič et al.
Damian Pociecha et al.
The twist-grain-boundary (TGB) phases, characterized by a periodic, helical arrangement of blocks made of polar smectic phases, SmAF and SmCF, have been discovered. They are observed for rod-like molecules with a strong longitudinal dipole ...
TRIM21-Mediated K11-Linked Ubiquitination of ID1 Suppresses Tumorigenesis and Promotes Cuproptosis in Esophageal Squamous Cell Carcinoma [0.03%]
TRIM21介导的ID1泛素化抑制食管鳞癌肿瘤发生并促进铜死亡
Lei Li,Yuqing Wang,Ruoxi Tian et al.
Lei Li et al.
Inhibitor of DNA binding 1 (ID1) is a key transcriptional regulator involved in the development of various cancers, including esophageal squamous cell carcinoma (ESCC). However, the mechanisms regulating ID1 ubiquitination in ESCC are not w...
Synergistic Photomagnetic and Photomechanical Dynamics in a Dysprosium-Based Smart Molecule [0.03%]
一种基于_dy_的智能分子中的协同光磁和光机械动力学现象研究
Yu-Han Wang,Shi-Kun Yan,Shuai Liang et al.
Yu-Han Wang et al.
Converging photomagnetic switching and photomechanical functionalities in molecular materials is critical for next-generation adaptive technologies, yet challenged by competing demands for rigid coordination environments to suppress quantum...
Inhibition of AMPKα Pathway by Podocyte GOLM1 Exacerbates Diabetic Nephrology in Mice [0.03%]
podocyte GOLM1 通过抑制 AMPKα 通路加重小鼠糖尿病肾病
Peng Xu,Kaiqiang Li,Huasong Liu et al.
Peng Xu et al.
Inflammation and oxidative stress contribute to diabetic nephrology (DN) progression. Golgi membrane protein 1 (GOLM1) is a Golgi type II transmembrane protein and associates with inflammation and oxidative stress. The present study tries t...
Harnessing Machine Learning to Enhance Transition State Search with Interatomic Potentials and Generative Models [0.03%]
利用机学习和互作用势及生成模型改进过渡态搜索
Qiyuan Zhao,Yunhong Han,Duo Zhang et al.
Qiyuan Zhao et al.
Transition state (TS) search is crucial for illuminating chemical reaction mechanisms but remains the major bottleneck in automated discovery because of the high computational cost. Recently, machine learning interatomic potentials (MLIPs) ...
Zhenye Zhan,Yulu Gao,Yue Liao et al.
Zhenye Zhan et al.
Memristive computing refers to the hardware implementation of artificial neural networks (ANNs) by employing memristive devices. It supports analog multiply-and-accumulation (MAC) operation in a compact and highly parallel manner, which can...
Nanomaterials Trigger Functional Anti-Tumoral Responses in Primary Human Immune Cells [0.03%]
纳米材料触发原代人类免疫细胞的抗肿瘤功能反应
Vincent Mittelheisser,Olivier Lefebvre,Mainak Banerjee et al.
Vincent Mittelheisser et al.
Targeting the immune system with nanoparticles (NPs) to deliver immunomodulatory molecules emerged as a solution to address intra-tumoral immunosuppression and enhance therapeutic response. While the potential of nanoimmunotherapies in reac...