PRO-LDM: A Conditional Latent Diffusion Model for Protein Sequence Design and Functional Optimization [0.03%]
基于条件潜扩散模型的蛋白质序列设计及功能优化方法
Sitao Zhang,Zixuan Jiang,Rundong Huang et al.
Sitao Zhang et al.
The diffusion model has grasped enormous attention in the computer vision field and emerged as a promising algorithm in protein design for precise structure and sequence generation. Here PRO-LDM is introduced: a modular multi-tasking framew...
Achieving Complex Nanostructures: The Role of Hydrogen in Controlling Mechanical Alloying and Microstructure Evolution in the TiVZrNbHf-Cu System [0.03%]
氢在TiVZrNbHf-Cu系统中机械合金化及组织演变中作用的研究得复杂纳米结构材料：氢对机械合金化及其微结构演变的控制作用研究
Lukas Schweiger,Florian Spieckermann,Peter Cengeri et al.
Lukas Schweiger et al.
Hydrogen is key in reducing greenhouse gas emissions in materials production. At the same time, it significantly affects mechanical properties, often causing unwanted embrittlement. However, rather than solely addressing these disadvantages...
Low-Power Tunable Micro-Plasma Device for Efficient and Scalable CO2 Valorization [0.03%]
一种用于高效和可扩展的二氧化碳利用的低能耗等离子体微装置
Bartu Karakurt,Hongkeng Zhu,Onder Soydal et al.
Bartu Karakurt et al.
Valorizing CO2 into chemical building blocks via efficient electrified processes could significantly decrease carbon emissions. In this work, a device that allows generation of tunable micro-plasma modes (arc, pulsed, pulsed arc) on a chip ...
Integrated Transcriptome and Metabolomics Analyses Show MYC as a Potential Therapeutic Target for Behçet's Uveitis [0.03%]
整合转录组和代谢组学分析显示MYC可能是Behçet虹膜炎的潜在治疗靶点
He Li,Lei Zhu,Zhaohuai Li et al.
He Li et al.
Behçet's uveitis (BU), characterized by recurrent bilateral panuveitis, is a severe manifestation of Behcet's disease (BD). However, disease-specific metabolic alterations in BU remain largely unknown. Here, untargeted metabolomics and sin...
Controllable Preparation of Millimeter-Scale In-Plane Charged Domain Wall in a Lead-Free Ferroelectric Film [0.03%]
无铅铁电薄膜平面内巨磁电阻效应的研究进展
Fang Liu,Mei-Xiong Zhu,Jia-Qi Liu et al.
Fang Liu et al.
Ferroelectric domain walls are emerging as active components in nanoelectronics, offering a transformative paradigm for non-volatile memory and logic technologies. In particular, in-plane charged domain walls stand out for their potential t...
Qikun Liu,Gai Huang,Zhiqiang Zhang et al.
Qikun Liu et al.
Forage crops not only provide food for livestock to meet the growing demands of the global population but are also essential for sustainable agricultural systems by rehabilitating infertile and marginal lands. A wide diversity of plant spec...
Ruoxuan Ye,Irum Firdous,Muhammad Fahim et al.
Ruoxuan Ye et al.
The growing demand for sustainable energy has triggered the exploration of innovative solutions to harness clean and renewable sources. In this pursuit, harvesting rain energy has emerged as a promising approach due to its unlimited availab...
Personalized Neoantigen Vaccine plus Regorafenib Increases Rgs2⁺CD8⁺ T Cells Infiltration and Reprograms the Tumor Microenvironment in Microsatellite Stable Colorectal Cancer Liver Metastases [0.03%]
个性化新抗原疫苗联合瑞戈非尼增加肝转移微卫星稳定型结直肠癌中RGS2⁺CD8⁺T细胞浸润并重新编程肿瘤微环境
Hengkai Chen,Bin Chen,Yuanfeng Yang et al.
Hengkai Chen et al.
Microsatellite stable colorectal cancer liver metastases (MSS-CRLM) resist immune checkpoint inhibitors due to their immunosuppressive tumor microenvironment (TME) and low mutation burden (TMB). A personalized neoantigen vaccine, Neo-CRCVAS...
Novel Antimicrobial Protein Fibroblast Growth Factor 8 Accelerates Skin Wound Healing via Directly Inhibiting Bacteria and Activating Glycolysis [0.03%]
新型抗菌蛋白成纤维细胞生长因子8通过直接抑制细菌和激活糖酵解促进皮肤伤口愈合
Ya-Zhen Hu,Ting Wang,Chang-Song Wu et al.
Ya-Zhen Hu et al.
Repairing and preventing infections of skin wounds are crucial for the body health. Fibroblast growth factors (FGFs) have functions of repairing skin wounds, while antimicrobial peptides/proteins (AMPs) can prevent the infections of skin. T...
Bioinspired Prolactin Pulse Release from Responsive Microneedles for Inhibiting Fatty Liver Formation [0.03%]
受生物启发的催乳素脉冲释放响应型微针抑制脂肪肝形成
Hongli Yin,Wenjuan Tang,Danqing Huang et al.
Hongli Yin et al.
Hormonal mechanisms of fatty liver formation require in-depth exploration, and corresponding therapeutic strategies are urgently needed. Here, through serological testing of mice with fatty liver, it is found that the rhythms of prolactin s...