Advancements in DNA-Driven Precision Modulation of Cell Surface Receptor for Programmable Cellular Functions [0.03%]
基于DNA的细胞表面受体精准调控技术研究取得进展
Hexin Nan,Ming Cai,Yiyu Wang et al.
Hexin Nan et al.
Precise modulation of receptor-mediated signaling is essential for understanding cellular communication and developing targeted therapeutics. Receptor engineering strategies focus on enhancing specificity, manipulating allosteric effects, a...
Gamma-Glutamyl Cysteine Ligase Activity as a Proxy for Human T Cell Function and Drug-Induced Immunosuppression [0.03%]
伽氨酰基半胱氨酸连接酶活性作为人体T细胞功能和药物致免疫抑制的替代标志物
Francisco Fueyo-González,Carmen Salto-Giron,Mehek Ningoo et al.
Francisco Fueyo-González et al.
T cell effector functions are critical for immune defense, but their dysregulation can cause diseases like immune exhaustion in cancer and loss of tolerance in autoimmunity. Curtailing these functions is essential in therapies such as chime...
In Vivo Dynamic Coronary Arteries Blood Flow Imaging Based on Multi-Cycle Phase Clustering Ultrafast Ultrasound [0.03%]
基于多周期相位聚类的超快超声心动图在体冠状动脉血流动态成像研究
Hao Yu,Jiabin Zhang,Feng Feng et al.
Hao Yu et al.
Echocardiography is the most primary clinical modality for dynamic cardiac imaging. However, the vigorous motion of myocardial tissue inherently causes inevitable signal aliasing between blood flow and myocardial tissue in traditional Doppl...
Innovative Design of PEI-Modified AMO-Layered Double Hydroxide for Efficient and Stable Direct Air Capture of CO2 [0.03%]
一种新型聚乙烯亚胺改性氨基官能团层状双氢氧化物材料用于高效稳定直接空气捕获二氧化碳
Meng Zhao,Liang Huang,Yanshan Gao et al.
Meng Zhao et al.
Emerging as a critical technology for atmospheric carbon dioxide (CO2) removal, the mass deployment of direct air capture (DAC) demands breakthrough innovations in efficient and stable adsorbent materials that simultaneously achieve high ca...
Modulating Macrophage-Nucleus Pulposus Cell Crosstalk via Sequential Drug Delivery Attenuates Disc Degeneration [0.03%]
序贯递药调控巨噬细胞-椎间盘核细胞对话以减轻椎间盘退变
Xiangzhen Kong,Rui Hu,Peng Zhang et al.
Xiangzhen Kong et al.
Intervertebral disc degeneration (IDD) is characterized by an inflammatory environment and dysregulation of the extracellular matrix metabolism (ECM). Improving nucleus pulposus cells (NPCs) condition first requires a supportive surrounding...
Covalent Organic Frameworks-Delivered Reuterin Drives Trained Immunity in Tumor-Associated Macrophages to Enhance Melanoma Immunotherapy via Glycerophospholipid Metabolism [0.03%]
共价有机框架递送鲁特醇通过甘油磷脂代谢增强肿瘤相关巨噬细胞的训练免疫从而提高黑色素瘤的免疫治疗效果
Jian-Gang Zhang,Xiao-Mei Zhang,Xi Wu et al.
Jian-Gang Zhang et al.
The gut microbiota is increasingly recognized as a promising therapeutic target in cancer treatment. However, the specific mechanisms by which gut bacteria and their metabolites exert therapeutic effects in melanoma remain poorly understood...
Integrating Molecular Dynamics and Machine Learning for Solvation-Guided Electrolyte Optimization in Lithium Metal Batteries [0.03%]
基于分子动力学和机器学习的指导溶剂化电解液优化用于锂金属电池
Xiwang Chang,Yang Yang,Weiheng Xu et al.
Xiwang Chang et al.
Optimizing liquid electrolytes is essential for achieving long-term cycling stability and high safety in lithium metal batteries. However, severe side reactions and lithium dendrite formation during repeated cycling lead to low Coulombic ef...
A Tunable Strategy for Continuous Production of Electrolyte-Free Formic Acid and Sodium Formate in a Solid-State-Electrolyte Based Electrocatalytic CO2 Reduction System [0.03%]
一种可调策略：在固态电解质基电催化CO2还原系统中连续生产不含电解质的甲酸和甲醛钠
Jinrui Guo,Wenqiang Qi,Rongrong Mo et al.
Jinrui Guo et al.
Electrocatalytic CO2 reduction reaction (CO2RR) based on solid-state-electrolyte (SSE) reactors can efficiently convert CO2 to electrolyte-free formic acid (HCOOH) solution, thereby circumventing energy-intensive downstream separation proce...
In Situ Formation of Mechanically Interlocked Heterointerfaces with Ultrahigh Bonding Strength for Mg-Based Multilayered Sheets [0.03%]
具有超高结合强度的机械互锁异质界面原位形成镁基多层板
Zhilei Yu,Wenbo Luo,Wei Xue et al.
Zhilei Yu et al.
Tailoring heterointerfaces is crucial for developing novel laminated metal composites (LMCs) with synergistic multifunctional structural properties. This study pioneers a novel approach to fabricating Mg-Ta incompatible LMCs via crystal ori...
Ionic Double-Network Hydrogels for Integrated Electromagnetic Shielding and Self-Powered Sensing in Wearable Electronics [0.03%]
用于穿戴式电子产品的集成电磁屏蔽及自供电传感器的离子双重网络水凝胶
Chenchen Wang,Yao Ding,Tianzhao Wu et al.
Chenchen Wang et al.
Cardiovascular implantable electronic devices (CIEDs) face dual challenges of high-frequency electromagnetic interference and functional integration. This work reports a multifunctional material constructed via a double-network ionic hydrog...