Weili Chang,Zhaoxu Meng,Yuezhu Zhao et al.
Weili Chang et al.
With the rising prevalence of obesity worldwide, the condition and its associated complications have become a significant public health challenge. The emergence of nanotechnology presents new opportunities for obesity treatment by enabling ...
Contribution of Prostaglandin E2-Induced Neuronal Excitation to Drug Resistance in Glioblastoma Countered by a Novel Blood-Brain Barrier Crossing Celecoxib Derivative [0.03%]
Chih-Jie Shen,Hsien-Chung Chen,Chien-Liang Lin et al.
Chih-Jie Shen et al.
Glioblastoma (GBM) is a highly aggressive brain tumor. Its poor prognosis is primarily due to recurrence and resistance to standard therapies, such as temozolomide (TMZ). Emerging evidence suggests that neuronal excitation within the tumor ...
Metabolic Programming Drives Protective and Inflammatory Monocyte Fates in Viral Encephalitis [0.03%]
Claire L Wishart,Alanna G Spiteri,Jian Tan et al.
Claire L Wishart et al.
Infiltrating monocytes can exert both protective and pathogenic effects during central nervous system (CNS) inflammation. However, the metabolic mechanisms that govern these divergent roles remain poorly understood, limiting opportunities f...
Reply to "Exploring Bacteria-Based Cancer Immunotherapy"-Comment on "Discovery of Intratumoral Oncolytic Bacteria Toward Targeted Anticancer Theranostics" [0.03%]
Eijiro Miyako
Eijiro Miyako
This manuscript is a formal response to the commentary by A/Prof. Dr. Chen-xi Li and colleagues regarding our previous publication in Advanced Science. We clarify the rationale, methods, and outcomes of our original study and highlight ongo...
Targeting Neutrophil/Eosinophil Extracellular Traps by Aptamer-Functionalized Nanosheets to Overcome Recalcitrant Inflammatory Disorders [0.03%]
Yongqiang Xiao,Xinyue Wang,Ming Liu et al.
Yongqiang Xiao et al.
Excessive generation of neutrophil extracellular traps (NETs) and eosinophil extracellular traps (EETs) can drive various inflammatory disorders by stimulating intracellular nucleic acid receptors. Although extracellular traps (ETs) are pro...
Wei Zhang,Jun Zou,Lingli Zhang
Wei Zhang
Traumatic brain injury (TBI), which refers to damage caused by external forces to the brain, significantly affects systemic organs and tissues, especially bone homeostasis. An increasing number of studies have revealed bidirectional crossta...
Dual-Graded Microstructure Engineering for Flexible Piezoresistive Sensors with High Sensitivity and Broad Linear Range in Physiological Monitoring [0.03%]
Ningning Bai,Dandan Xu,Zhuang Su et al.
Ningning Bai et al.
Flexible piezoresistive sensors that offer both high sensitivity and a broad linear detection range are highly desirable for wearable health monitoring, as they facilitate simplified circuit design and enable accurate detection of subtle ph...
Synthesis of Elastic Metallic Nickel by Solvent-Ligand-Mediated Reductive Assembly [0.03%]
溶剂-配体介导还原缩合制备弹性金属镍
Haiyan An,Guoying Tan,Pingru Su et al.
Haiyan An et al.
Metallic foams hold significant promise as lightweight structural materials. However, most conventional metallic foams are inherently rigid and brittle, frequently undergoing structural collapse. There is an urgent demand to develop cost-ef...
Inhibition of FOXM1 Synergizes with BH3 Mimetics Venetoclax and Sonrotoclax in Killing Multiple Myeloma Cells through Repressing MYC Pathway [0.03%]
FOXM1抑制与BH3模拟物维奈克拉克和桑托克拉克协同作用通过抑制MYC途径杀死多发性骨髓瘤细胞
Zhi Wen,Yidan Wang,Kathryn C Fox et al.
Zhi Wen et al.
Relapsed and refractory multiple myeloma (RRMM) remains the leading cause of MM mortality. FOXM1 is strongly associated with RRMM, making it a compelling therapeutic target. Through three low-throughput screenings, we have identified nine F...