MTCH2 Deficiency Promotes E2F4/TFRC-Mediated Ferroptosis and Sensitizes Colorectal Cancer Liver Metastasis to Sorafenib [0.03%]
MTCH2缺陷通过促进E2F4/TFRC介导的铁死亡增强了结直肠癌肝转移对索拉非尼的敏感性
Pu Xing,Jiangbo Chen,Hao Hao et al.
Pu Xing et al.
Ferroptosis is a specific type of lipid peroxide-mediated cell death which is crucial in tumor suppression. While the mitochondrial carrier homolog 2 (MTCH2) is implicated in lipid homeostasis and mitochondrial metabolism, its role in ferro...
Nature-Inspired Nanostructures from Multiple-Species Biomembranes: Rational Engineering and Therapeutic Applications in Tumor-Targeted Nanomedicine [0.03%]
受自然启发的多功能生物纳米结构的理性工程及其在肿瘤靶向治疗中的应用研究
Xiaodan Wei,Chi Wang,Xiangyan Chen et al.
Xiaodan Wei et al.
The advent of nanomedicine is profoundly revolutionizing conventional paradigms in cancer therapeutics. Selected formulations encompassing lipid nanoparticles and polymeric nanoparticles have already attained regulatory approval for clinica...
From Charge Storage Rulebook Rewriting to Commercial Viability of Zinc-Manganese Batteries [0.03%]
从锌锰电池储电特性再认知至商业可行性探讨
Xinhua Zheng,Bibo Han,Shikai Liu et al.
Xinhua Zheng et al.
Aqueous zinc-manganese oxide (Zn-MNO) batteries represent a compelling solution for grid-scale energy storage due to their inherent safety, cost-effectiveness and ecological compatibility. However, the commercialization of this technology f...
An MOF-Enhanced Anti-Fouling Immunoprobe Platform for Efficient Direct Screening of Pancreatic Cancer [0.03%]
一种高效的用于直接筛查胰腺癌的MOF增强型防污免疫探针平台
Wenjuan Yang,Shujuan Mao,Hao Zhu et al.
Wenjuan Yang et al.
Monitoring biomarkers offers insights for early disease (e.g., cancer, chronic diseases) screening, treatment guidance and response evaluation. To tackle challenges in precise biomarker detection in complex blood samples, we propose a metal...
Anti-Icing Organogel Enables Quasi-Homogeneous Supercooling Preservation of Mouse Hearts [0.03%]
抗结冰有机凝胶使小鼠心脏准均匀过冷保存成为可能
Junhao Li,Wei Wang,Chenghao Li et al.
Junhao Li et al.
Supercooling preservation holds great promise for extending the storage limits of organs. However, supercooled systems are susceptible to stochastic ice nucleation, which can cause fatal damage to the organs. In this study, an organogel int...
STING COPII ER Export Trafficking and Signaling Primed by Phosphorylation Switches [0.03%]
由磷酸化开关启动的STING COPII ER 出口转运和信号转导
Yanan Nan,Dongxiao Cui,Jiajian Guo et al.
Yanan Nan et al.
Despite advances in understanding the STING signaling pathway, mechanisms governing cyclic GMP-AMP (cGAMP)-induced STING trafficking out of the endoplasmic reticulum (ER) remain unclear. This study reveals that STING localization is regulat...
Single-Cell Transcriptome Profiling Reveals Conserved IFNγ-IL8 Signaling-Induced Antibacterial Neutrophil States during Bacterial Infection [0.03%]
单细胞转录组分析揭示细菌感染过程中保守的IFNγ-诱导的抗细菌中性粒细胞状态
Xue Zhai,Minghao Zhang,Kang Li et al.
Xue Zhai et al.
Streptococcus agalactiae is a significant pathogen in both humans and animals, yet the immune cell subtype dynamics during infection remain poorly defined. Leveraging the high susceptibility and tractability of Nile tilapia (Oreochromis nil...
Lin Wang,Wei Hao,Shen Chen et al.
Lin Wang et al.
Chiral 3D perovskites possess remarkable chiroptoelectronic properties, which exhibit potential for overcoming the intrinsic limitations of carrier/exciton dynamics in low-dimensional chiral perovskites. However, chiral 3D perovskites face ...
SF3A3 Drives Tumorigenesis in Endometrial Cancer by Enhancing c-FOS Expression and Represents a Potential Therapeutic Target [0.03%]
SF3A3通过增强c-FOS表达驱动子宫内膜癌的发生发展并可作为潜在治疗靶点
Wei Yu,Yi Gu,Hengrui Zhang et al.
Wei Yu et al.
Aberrant alternative splicing plays a crucial role in tumorigenesis. Here, splicing factor 3A subunit 3 (SF3A3) is significantly upregulated in endometrial cancer (EC) tissues and associated with poor prognosis. Functionally, SF3A3 drives t...
Inductive-Associative Meta-learning Pipeline with Human Cognitive Patterns for Unseen Drug-Target Interaction Prediction [0.03%]
基于人类认知模式的归纳联想元学习流水线用于预测未知药物靶点相互作用
Xiaoqing Lian,Tianxu Lv,Jie Zhu et al.
Xiaoqing Lian et al.
Significant differences in protein structures hinder the generalization of existing drug-target interaction (DTI) models, which often rely heavily on pre-learned binding principles or detailed annotations. In contrast, BioBridge designs an ...