Cathepsin K Aggravates Pulmonary Fibrosis Through Promoting Fibroblast Glutamine Metabolism and Collagen Synthesis [0.03%]
组织蛋白酶K通过促进成纤维细胞谷氨酰胺代谢和胶原合成加重肺纤维化
Mengting Chen,Xiaoxiao Meng,Yong Zhu et al.
Mengting Chen et al.
Fibroblast collagen synthesis is a hallmark of the pathogenesis and progression of pulmonary fibrosis (PF). However, the factors that trigger the abnormal activation of fibroblasts in PF are still not well understood. Using proteomics and s...
Choroid Plexus Fibroblast-ILC2 Niche Promotes Adult Hippocampal Neurogenesis after Traumatic Brain Injury [0.03%]
脑外伤后脉络丛成纤维细胞-ILC2巢促进成人海马神经发生
Shiqi Gao,Xiaoming Guo,Sixuan Tian et al.
Shiqi Gao et al.
Mounting evidence has indicated that immune signals originating from the brain's border tissues will exert a profound influence on brain parenchyma neural cells. However, the structural component alterations and immune cell infiltration cha...
Atrial Fibroblasts-Derived Extracellular Vesicles Exacerbate Atrial Arrhythmogenesis [0.03%]
心房成纤维细胞源性外泌体通过激活Toll样受体4促进心律失常发生
Yue Yuan,Xinbo Zhao,Xuejie Han et al.
Yue Yuan et al.
Cardiac fibroblasts (CFs) secrete exosomes, and their cargo represents a new means of cellular communication in cardiovascular diseases, including atrial fibrillation (AF). We aimed to explore the contribution of atial CFs (ACFs)-derived ex...
Harnessing the Immunomodulation of UV-Exposed Keratinocyte Extracellular Vesicles for Inflammatory Disorder Treatment [0.03%]
利用UV辐照角质细胞外泌体的免疫调节作用治疗炎症疾病
Lu Liu,Ding Yang,Jingsen Ji et al.
Lu Liu et al.
Sunbathing excessively heightens the risk of skin carcinogenesis due to ultraviolet (UV)-mediated immunosuppression. Keratinocytes, the primary cells in epidermis, play a pivotal role in orchestrating the UV-induced immunosuppressive respon...
Ion-Pair Interactions in Polyphenylene-Based Quaternized Membranes Designed for Phosphoric Acid-Doped Proton Exchange Membranes for High-Temperature Fuel Cells [0.03%]
用于高温燃料电池的掺磷酸质子交换膜的聚苯基季铵化膜中的离子对相互作用
Lin Guo,Kenji Miyatake,Ahmed Mohamed Ahmed Mahmoud et al.
Lin Guo et al.
Phosphoric acid (PA)-doped proton exchange membranes (PEMs) face significant challenges owing to the loss of PA, particularly under high humidity conditions. Ion-pair interactions between PA and quaternary ammonium (QA) groups can effective...
Deciphering the Acetabular Labrum's Cellular Atlas: MDK Inhibition as a Novel Therapeutic Method for Developmental Dysplasia of the Hip [0.03%]
髋关节发育不良的新型治疗策略：解析股骨头软骨盂缘细胞图谱及MDK抑制作用研究
Runze Yang,Huiling Liu,Minghao Ge et al.
Runze Yang et al.
DDH is far more than just a contributing factor to hip osteoarthritis; it represents a formidable challenge to the health of infants and young children. While historical research has largely focused on the osseous abnormalities associated w...
Realizing High Performance in P-Type SnBi2Te4 Through Synergistically Improving Effective Mass and Suppressing Bipolar Thermal Conductivity [0.03%]
通过协同提高有效质量和抑制双极热导率实现P型SnBi2Te4的高性能
Ke Zhao,Dongyang Wang,Tao Hong et al.
Ke Zhao et al.
Thermoelectric materials, which facilitate the mutual conversion between thermal and electrical energy, offer a promising alternative for sustainable energy solutions. High-performance thermoelectric materials require excellent electrical c...
Synthesis of Diaryl- and Dialkynylphosphinates From Ubiquitous PV Sources via a Redox-Neutral Approach [0.03%]
通过电中性方法由通用PV原料合成 diaryl-和dialkynyl磷化合物
Tobias Schneider,Kai Schwedtmann,Jannis Fidelius et al.
Tobias Schneider et al.
Organophosphinic acids, R2P(O)(OH), and their derivatives are versatile compounds with applications in catalysis, material chemistry, biomolecular bridging, metal extraction, and flame retardancy. Current synthetic methods primarily rely on...
Human Nervous System-Based Biohybrid Robot-On-A-Chip with Sensing Function for Toxicity Screening [0.03%]
一种基于人类神经系统的具有感应功能的芯片级生物机器人毒理筛查
Minkyu Shin,Joungpyo Lim,Seewoo Kim et al.
Minkyu Shin et al.
Biohybrid robots and biohybrid robot-on-a-chip have been developed for drug screening and toxicity screening the complementing animal experiments. A sensing system is needed to evaluate the response to external stimulation, but until now, o...
Pancreatic Cancer-Derived Extracellular Vesicles Enriched with miR-223-5p Promote Skeletal Muscle Wasting Associated with Cachexia [0.03%]
胰腺癌来源富含miR-223-5p的外泌体促进恶病质相关肌少症发生的机制研究
Kangjing Xu,Rongxi Shen,Li Zhang et al.
Kangjing Xu et al.
Pancreatic ductal adenocarcinoma (PDAC) with cachexia-related muscle wasting as the main manifestation is associated with poor overall survival. Extracellular vesicles (EVs) are key mediators of inter-organ communication. Here, EVs and EV-m...