Ubiquitination-Dependent LLGL2 Degradation Drives Colorectal Cancer Progression via THBS3 mRNA Stabilization [0.03%]
泛素依赖的LLGL2降解通过THBS3 mRNA稳定促进结直肠癌进展
Jiayan Huang,Tiantian Zhang,Huimin Li et al.
Jiayan Huang et al.
Colorectal cancer (CRC) is the second most common cause of cancer-related deaths worldwide is highly associated with distant organ metastasis. Lethal(2) giant larvae protein homolog 2 (LLGL2) is often dysregulated in various tumors; however...
Highly Conductive Liquid Metal Emulsion Gels for Three-Dimensionally Printed Stretchable Electronics [0.03%]
适用于三维打印的液态金属乳胶凝胶及其可拉伸电子产品
Qianying Lu,Ting Fang,Chenyang Ye et al.
Qianying Lu et al.
Gallium-based liquid metals are promising for stretchable electronics due to their inherent deformability and excellent conductivity. However, the lack of a scalable and automated fabrication process has limited their practical applications...
Delivery of Molecular Hydrogen for Precision Immunomodulation: Mechanisms, Detection Methods, and Applications [0.03%]
分子氢的递送实现精准免疫调控：机制、检测方法与应用前景展望
Gangfeng Li,Hannan Cui,Ruixiao Fan et al.
Gangfeng Li et al.
The delivery of molecular hydrogen (H2) is increasingly recognized for its potential in precision immunomodulation, primarily through multiple pathways such as antioxidant action, modulation of inflammatory factors, and inhibition of apopto...
Optogenetic-Controlled iPSC-Based Vaccines for Prophylactic and Therapeutic Tumor Suppression in Mice [0.03%]
基于 optogenetics 控制的诱导多能干细胞系疫苗对小鼠肿瘤的预防和治疗作用
Longliang Qiao,Lingxue Niu,Zhihao Wang et al.
Longliang Qiao et al.
Induced pluripotent stem cells (iPSCs) share similar cellular features and various antigens profiles with cancer cells. Leveraging these characteristics, iPSCs hold great promise for developing wide-spectrum vaccines against cancers. In pra...
Topological Insulator Bi2Te3 Anode for Aqueous Aluminum-Ion Batteries: Unveiling the Role of Hydronium Ions [0.03%]
用于水性铝离子电池的拓扑绝缘体Bi2Te3阳极：揭示hydronium离子的作用
Puja De,Petr Lazar,Michal Otyepka et al.
Puja De et al.
The primary scientific challenge in advancing aqueous aluminum-ion batteries (AAIBs) is achieving reversible plating/stripping of the Al metal anode, limited by its low deposition potential (-1.667 V vs SHE) and surface passivation in the a...
Boron Difluoride Formazanate Dye With Donor Planarization Engineering for 1060 nm Laser Activated Photothermal Theranostics [0.03%]
用于1060nm激光激活光热诊疗的硼氟化物方酰腙染料及给电子平面化工程技术
Kang Xu,Mengchen Luo,Weili Wang et al.
Kang Xu et al.
Phototheranostics within the second near-infrared (NIR-II, 1000-1700 nm) window offer considerable advantages compared to those operating in the visible and first near-infrared region (NIR-I, 700-900 nm). Herein, a donor-acceptor-donor (D-A...
Controlling Release Kinetics of an Adjuvant from a Depot Improves the Efficacy of Local Immunotherapy in Metastatic Cancer [0.03%]
控制佐剂从储库中的释放动力学可改善转移性癌症局部免疫治疗的疗效
Joshua J Milligan,Rachel L Strader,Arunangshu Chakrabarty et al.
Joshua J Milligan et al.
Biomaterials can improve cancer immunotherapies by controlling their release and thereby optimizing their time-dependent engagement of the immune system. In this study, an approach is described to control the release of a potent immunostimu...
Adaptive Antioxidant Nanomedicines Inhibit Ferroptosis in Renal Tubular Epithelial Cells to Alleviate Diabetic Kidney Disease [0.03%]
自适应型抗氧化纳米药物通过抑制肾小管上皮细胞铁死亡防治糖尿病肾脏疾病
Zerun Liu,Ting Huang,Ying Hong et al.
Zerun Liu et al.
Diabetic kidney disease (DKD) imposes a heavy medical burden worldwide due to the lack of effective treatment. High levels of mtROS and mitochondrial damage in the renal tubules are the initiating and core factors driving the progression of...
Phosphorylation-Dependent Stabilization of Collaborator of ARF (CARF) Suppresses Lymphoma Cell Proliferation [0.03%]
磷酸化依赖的ARF合作者(CARF)稳定抑制淋巴细胞增殖
Li Qu,Zhuang Wei,Shuting Zhou et al.
Li Qu et al.
Uncontrolled cell proliferation drives tumorigenesis and malignant progression, making cell cycle regulation a promising strategy for cancer therapy. Phosphorylation plays pivotal roles in cancer initiation and metastasis by regulating the ...
Biomimetic Analysis of Neurotransmitters for Disease Diagnosis through Light-Driven Nanozyme Sensor Array and Machine Learning [0.03%]
基于光驱动纳米酶传感器阵列和机器学习的仿生神经递质疾病诊断分析
Kun Yu,Siyuan Lu,Kaiwen Qiu et al.
Kun Yu et al.
Neurological diseases, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis, pose a significant global health challenge due to their complex pathogenesis and widespread prevalence. These disorders are often associated ...