Bioactive Silk Sericin/Bioceramic Nerve Guidance Conduit for Effective Repair of Long-Gap Transected Peripheral Nerve Injury through Regulating Schwann Cells [0.03%]
生物活性丝素/生物陶瓷神经导管通过调节施万细胞有效修复长节段外周神经损伤
Qiangfei Su,Jian Wang,Yu Song et al.
Qiangfei Su et al.
Schwann cells are pivotal in generating a pro-regenerative microenvironment for long-gap peripheral nerve injury (PNI) repair via their orchestrated behaviors, including cell migration, proliferation, and secretion. Bioceramics can release ...
Precise Modulation of Reorganization Energy through Methyl Substitution for High Performance Organic Solar Cells [0.03%]
通过甲基取代精确调节重组能以实现高性能有机太阳能电池
Li Chen,Chaoyue Zhao,Joshua Yuk Lin Lai et al.
Li Chen et al.
Efficient charge transport and minimized energy loss are critical for advancing the performance of organic solar cells (OSCs). In this study, a series of quinoxaline-based electron acceptors, BQx-MeF, BQx-MeCl, and BQx-MeBr, featuring methy...
Microfluidic Biochip-Based Multiplexed Profiling of Small Extracellular Vesicles Proteins Integrated with Machine Learning for Early Disease Diagnosis [0.03%]
基于微流控生物芯片的外泌体蛋白多重检测技术及其与机器学习结合的早期疾病诊断方法研究
Xue Zhang,Yibin Jia,Zhikai Li et al.
Xue Zhang et al.
Accurate early diagnosis is essential for preventing diseases and improving cure and survival rates. There are no reliable early-diagnosis biomarkers for most major diseases. Here, esophageal squamous cell carcinoma (ESCC) is used as a dise...
Subgenome Partitioning and Polyploid Genome Evolution in the Loach Family Botiidae (Order Cypriniformes) [0.03%]
鳅科鱼类亚基因组划分及全基因组分析研究(鲤形目)
Yunyun Lv,Jia Li,Yanping Li et al.
Yunyun Lv et al.
Vertebrates have undergone two rounds of whole-genome duplication (WGD), termed 1R and 2R, with a third, teleost-specific duplication (TSGD or 3R) occurring in ray-finned fishes. In the order Cypriniformes, additional lineage-specific WGDs ...
Hyperelastic Starch Hydrogel Configures Edible and Biodegradable All-Components for Soft Robots [0.03%]
富淀粉超弹性水凝胶配置用于软体机器人的全部可食用和可降解组件
Siyu Yao,Haohao Hu,Mengfan Zhang et al.
Siyu Yao et al.
Developing edible and biodegradable structural materials is a promising solution to the increasing risk of plastic pollution. Starch has been widely used in foods such as noodles, and puddings for thousands of years, but with low mechanical...
Engineered Anti-Senescence Trachea With Post-Transplanted Regenerative Homeostasis [0.03%]
具有移植后再生稳态的工程化抗衰老气管
Ziyin Pan,Hai Tang,Lanlan Wang et al.
Ziyin Pan et al.
Post-transplanted dysfunction remains the key unsolved challenge to construct bioengineered complex organs. Herein, by analyzing the bioengineered trachea, it is found that multiple tissue senescences occur, and poor endogenous cellular con...
PIM1 Attenuates Innate Immunity to Foster Coronavirus Replication through Ubiquitin Ligase β-TrCP-Mediated IFNAR1 Degradation [0.03%]
PIM1通过泛素连接酶β-TRCP介导的IFNAR1降解来削弱先天免疫从而促进冠状病毒复制
Qianya Wan,Lin Zhu,Cien Chen et al.
Qianya Wan et al.
Virus infection stimulates proto-oncoprotein PIM1 kinase expression, but its importance and the biological functions of this process are poorly understood. Herein, PIM1 promotes IFNAR1 degradation to attenuate cellular innate immunity durin...
Engineered Dual-Function Antibody-Like Proteins to Combat SARS-CoV-2-Induced Immune Dysregulation and Inflammation [0.03%]
用于对抗SARS-CoV-2所致免疫紊乱和炎症的工程双功能抗体蛋白
Yizhuo Wang,Chenwu Bai,Kerui Hou et al.
Yizhuo Wang et al.
Complement dysregulation and immune hyperactivation are pivotal factors contributing to the mortality associated with SARS-CoV-2 infection. Engineered Antibody-like proteins (ALPs) targeting the SARS-CoV-2 spike protein are engineered to ad...
Polarization-Improved Bidirectional-Pump Atomic Magnetometer Based on Spin-Decoupled Metasurface [0.03%]
基于自旋解耦超表面的极化改进型双向泵浦原子磁力计
Shuo Sun,Jiahao Zhang,Rongtong Zhu et al.
Shuo Sun et al.
The optically pumped atomic magnetometer (OPAM) has emerged as an advanced instrument for magnetic field detection. However, the performance of conventional OPAMs is constrained by factors such as non-uniform atomic polarization and insuffi...
Exosomes From Intestinal Epithelial Cells Promote Hepatic Differentiation of Liver Progenitor Cells in Gut-Liver-on-a-Chip Models [0.03%]
基于肠道-肝脏芯片模型的肠上皮细胞外囊泡对卵圆细胞肝向分化的影响研究
Liang Ye,Shi Li,Guofang Bi et al.
Liang Ye et al.
Hepatic progenitor cells (HPCs) are frequently overactivated, and their differentiation into hepatocytes is impaired in advanced liver diseases. To explore the effects of intestinal epithelial cells and their exosomes on the hepatic differe...