Mingqi Zhao,Shanzhi Lyu,Yingchao Ma et al.
Mingqi Zhao et al.
Devastating natural disasters are prompting the need for effective early warning systems. The warning systems relying on cables or batteries are much expensive and not suitable for low-lying areas or remote environments. This research propo...
Hierarchical Prediction and Perturbation of Chromatin Organization Reveal How Loop Domains Mediate Higher-Order Architectures [0.03%]
分层预测和扰动染色质组织揭示了环域如何介导高级结构
Jiachen Wei,Yue Xue,Yi Qin Gao
Jiachen Wei
The genome is folded within the dense cell nucleus in a hierarchical manner, resulting in complex interactions between distinct folding strategies at various length scales. To elucidate how short-range loop domains regulate higher-order str...
Cascade-Targeted Nanoparticles for Enhanced Gemcitabine Delivery and Adenosine Metabolism Modulation to Overcome Treatment Resistance in Pancreatic Cancer [0.03%]
用于增强吉西他滨递送和黄苷代谢调节的级联靶向纳米颗粒以克服胰腺癌治疗抵抗性
Hongrui Fan,Hongyi Chen,Haolin Song et al.
Hongrui Fan et al.
KRAS mutations are find in over 90% of pancreatic ductal adenocarcinoma (PDAC) cases, making PDAC exhibit intrinsic resistance to chemotherapy and reshape the immunosuppressive tumor microenvironment (TME), disappointing the clinically pref...
Multi-Region Brain Organoids Integrating Cerebral, Mid-Hindbrain, and Endothelial Systems [0.03%]
集成了大脑、中后脑和内皮系统的多区域脑器官体
Anannya Kshirsagar,Hayk Mnatsakanyan,Sai Kulkarni et al.
Anannya Kshirsagar et al.
Brain organoid technology has revolutionized the ability to model human neurodevelopment in vitro. However, current techniques remain limited by their reliance on simplified endothelial cell populations. Multi-Region Brain Organoids (MRBOs)...
Distributed Temporal Coding of Visual Memory Categories in Human Hippocampal Neurons Revealed by an Interpretable Decoding Model [0.03%]
一种可解释的解码模型揭示了人类海马神经元中视觉记忆类别的分布式时序编码
Xiwei She,Bryan J Moore,Brent M Roeder et al.
Xiwei She et al.
The hippocampus is crucial for forming new episodic memories. While its role in encoding spatial and temporal information (where and when) is well understood, how it encodes objects (what) remains unclear due to the high dimensionality of o...
Aberrant Mitochondrial Metabolism in Alzheimer's Disease Links Energy Stress with Ferroptosis [0.03%]
阿尔茨海默病中异常的线粒体代谢将能量压力与铁死亡联系起来
Francesca Alves,Darius Lane,Adam Wahida et al.
Francesca Alves et al.
Alzheimer's disease (AD) is defined by β-amyloid plaques and tau-containing neurofibrillary tangles, but the ensuing cellular derangements that culminate in neurodegeneration remain elusive. Here, a mechanistic link between two AD pathophy...
Deep Learning-Assisted Rapid Bacterial Classification Based on Raman Spectroscopy of Bacteria Lysed by Acoustically Driven Fiber-Tip Vibration [0.03%]
基于声驱动纤振裂解细菌的拉曼光谱的深度学习辅助快速细菌分类方法
Yukai Liu,Miaomiao Ji,Xiao Ren et al.
Yukai Liu et al.
Rapid and accurate identification of bacterial pathogens is critical for effective clinical decision-making and combating antibiotic resistance. Surface-enhanced Raman spectroscopy (SERS) combined with machine learning (ML) offers a powerfu...
Efficient Somatic Cell Nuclear Transfer by Overcoming Both Pre- and Post-Implantation Epigenetic Barriers [0.03%]
克服植入前和植入后表观遗传障碍的高效体细胞克隆技术
Yamei Li,Shiyu Sun,Yuting Xu et al.
Yamei Li et al.
Mammalian cloning through somatic cell nuclear transfer (SCNT) involves reprogramming terminally differentiated cells into totipotent embryos. Epigenetic barriers inherited from somatic cells impede reprogramming efficiency and lead to low ...
Electrochemical CO2 Reduction on Janus Dual-Atom Catalysts: Critical Role of Oxygen Coordination and an Effective Descriptor [0.03%]
Janus双原子催化剂上的电化学CO2还原:氧配位的 critical作用及有效描述符
Hongling Liu,Zhichao Yu,Jia Zhao et al.
Hongling Liu et al.
Dual-atom catalysts (DACs) embedded in nitrogen-doped graphene have been widely studied for electrochemical CO2 reduction (CO2R), primarily yielding CO. However, achieving selectivity for C1 hydrocarbons remains challenging. Here, 32 Janus ...
Dual-Biomimetic Bone Adhesive with Osteoimmunomodulatory Capabilities for Anatomical Reconstruction of Comminuted Fractures [0.03%]
一种用于复杂骨折解剖重建的双仿生骨粘合剂及其免疫调节作用
Junyao Cheng,Hufei Wang,Ming Li et al.
Junyao Cheng et al.
The development of bone adhesives capable of restoring natural bone structure and function represents a pioneering advancement in surgical technology, offering significant potential to improve the treatment outcomes of comminuted fractures....