Sepsis protects the myocardium and other organs from subsequent ischaemic/reperfusion injury via a MAPK-dependent mechanism [0.03%]
败血症通过MAPK依赖性机制保护心肌和其它器官免受后续缺血/再灌注损伤
Criona M Walshe,John G Laffey,Leo Kevin et al.
Criona M Walshe et al.
Background: Sepsis has been shown to precondition the intact heart against ischaemia/reperfusion (IR) injury, and prior endotoxin exposure of cells in in vitro models has shown evidence of protection against subsequent si...
The receptor for advanced glycation end products in ventilator-induced lung injury [0.03%]
血管紧张素原在机械通气诱导的肺损伤中的作用
Maria T Kuipers,Hamid Aslami,Pieter Roel Tuinman et al.
Maria T Kuipers et al.
Background: Mechanical ventilation (MV) can cause ventilator-induced lung injury (VILI). The innate immune response mediates this iatrogenic inflammatory condition. The receptor for advanced glycation end products (RAGE) ...
Neutrophil extracellular traps in the host defense against sepsis induced by Burkholderia pseudomallei (melioidosis) [0.03%]
铜绿假单胞菌（ melioidosis）引起的败血症中中性粒细胞胞外陷阱在宿主防御中的作用
Hanna K de Jong,Gavin Ckw Koh,Ahmed Achouiti et al.
Hanna K de Jong et al.
Background: Neutrophil extracellular traps (NETs) are a central player in the host response to bacteria: neutrophils release extracellular DNA (nucleosomes) and neutrophil elastase to entrap and kill bacteria. We studied ...
Early and dynamic changes in gene expression in septic shock patients: a genome-wide approach [0.03%]
基因表达谱对脓毒性休克患者早期动态变化的初步研究
Marie-Angélique Cazalis,Alain Lepape,Fabienne Venet et al.
Marie-Angélique Cazalis et al.
Background: As early and appropriate care of severe septic patients is associated with better outcome, understanding of the very first events in the disease process is needed. Pan-genomic analyses offer an interesting opp...
Raxibacumab augments hemodynamic support and improves outcomes during shock with B. anthracis edema toxin alone or together with lethal toxin in canines [0.03%]
拉西巴库单抗可增强博德特氏菌恶变毒素和/或致死毒素引起的犬休克状态的血动力学支持并改善预后
Kenneth E Remy,Xizhong Cui,Yan Li et al.
Kenneth E Remy et al.
Background: Lethal and edema toxin contribute to shock and lethality with Bacillus anthracis. We showed previously in a 96-h sedated canine model that raxibacumab, a monoclonal antibody against protective antigen, augment...
The effect of therapeutic plasma exchange on the inflammatory response in septic shock: a secondary analysis of the EXCHANGE-1 trial [0.03%]
治疗性血浆交换对感染性休克的炎症反应的影响：EXCHANGE-1试验的二次分析
Background: Sepsis and septic shock, defined by a profound immune dysregulation, are among the leading causes of death in the intensive care unit (ICU). Despite advances in understanding the underlying pathophysiology, ev...
Non-invasive monitoring of microcirculation dynamics in hypovolemic shock: a novel application of diffuse correlation spectroscopy [0.03%]
弥散相关光谱在低血容量性休克微循环动态无创监测中的新型应用研究
Background: Microcirculatory dysfunction is a poor prognostic indicator for the management of critically ill patients, highlighting the need for the development of appropriate assessment methods. Current microcirculatory ...