Mouse models to study von Willebrand factor in inflammation: a scoping review [0.03%]
用于炎症研究von Willebrand因子的小鼠模型：综述性文章
Hassan Masood,Veronica DeYoung,Peter Andrisani et al.
Hassan Masood et al.
Background: VWF is released from activated endothelial cells and activated platelets in response to vascular injury, and is now recognized as an important contributor to a growing number of inflammatory conditions. This s...
Kirsten A Kalverda,Lizzy Wijmans,Lieuwe D J Bos et al.
Kirsten A Kalverda et al.
Background: Survivors of the early exudative phase of acute respiratory distress syndrome (ARDS) may develop a fibroproliferative repair response and persistent microstructural remodeling associated with adverse outcomes....
Source-controlled bacterial peritonitis improves survival but leaves persistent lung inflammation and airway IgA loss [0.03%]
病原菌控制的腹膜炎能提高生存率但会导致持续性肺部炎症和分泌型IgA水平降低
Azusa Kato,Masafumi Saito,Hiromi Miyazaki et al.
Azusa Kato et al.
Background: Cecal ligation and puncture (CLP) is widely used to develop polymicrobial sepsis model in rodents, yet conventional CLP is not advantageous for evaluating long-term outcomes because most animals succumb withou...
Noradrenaline-trajectory phenotypes in septic shock: derivation and external validation in two independent cohorts [0.03%]
脓毒性休克中的去甲肾上腺素反应表型：在两个独立队列中推导和外部验证
Gargi Yonatan,Amir Cohen,Dorit Stein et al.
Gargi Yonatan et al.
Background: Septic shock is heterogeneous, and noradrenaline (NA) requirements evolve over time in ways that reflect vascular responsiveness and shock biology. Whether long-horizon NA dose-trajectory phenotypes are reprod...
Exploratory dose modeling of hemoadsorption in pediatric septic shock [0.03%]
探索性剂量模型在儿童脓毒性休克血液吸附中的应用
Gabriella Bottari
Gabriella Bottari
Background: Clinical outcomes of hemoadsorption (HA) in sepsis remain uncertain despite demonstrated biological efficacy in in vivo models. Persistent knowledge gaps concern both patient selection-now increasingly interpr...
Sex-related differences in lung injury distribution and outcomes in COVID-19 acute respiratory failure: insights from the CT-COVID19 multicenter study group [0.03%]
CT-COVID19多中心研究组关于Covid-19急性呼吸衰竭中肺损伤分布及预后的性别差异性分析
Davide Signori,Alice Nova,Yi Xin et al.
Davide Signori et al.
Background: Sex-related differences have been consistently reported in the epidemiology of acute hypoxemic respiratory failure (AHRF) and COVID-19. However, whether computed tomography (CT)-derived measures of lung injury...
Matters arising: personalised viscoelastometry-guided systemic thrombolysis for high- and intermediate-high-risk acute pulmonary embolism in the ICU: a single-centre randomised controlled interventional feasibility trial [0.03%]
ICU中高危和极高危急性肺栓塞个体化血流变图检查指导全身溶栓治疗的事后研究：一项中心随机对照干预可行性试验
Maajid Mohi Ud Din Malik,Rajesh Prasad Jayaswal
Maajid Mohi Ud Din Malik
Digital performance testing reveals how redesigned return cannulas can enhance VV-ECMO performance [0.03%]
数字性能测试揭示了如何通过改进返回灌注管来提升静脉-动脉体外膜肺氧合的性能
Beata Ondrusova,Argyrios Petras,Johannes Szasz et al.
Beata Ondrusova et al.
Background: Veno-venous extracorporeal membrane oxygenation (VV-ECMO) provides life support for patients with severe respiratory failure by oxygenating blood when the lungs are impaired. Standard VV-ECMO uses two cannulas...
Pre-discharge neutrophil:lymphocyte ratio and lymphopenia are associated with post-hospital long-term outcomes among survivors of critical illness [0.03%]
重症监护幸存者出院前的中性粒细胞与淋巴细胞比率和淋巴细胞减少与医院长期预后相关性研究
Lucas L Marinho,John C Marshall,Danielle Jeong et al.
Lucas L Marinho et al.
Mass cytometry reveals complex neutrophil heterogeneity in patients with severe sepsis [0.03%]
高通量质谱流式细胞术发现严重脓毒症患者复杂的中性粒细胞异质性
Patricia D A Lima,Christina Yu,Miranda Hunt et al.
Patricia D A Lima et al.
Rationale: Sepsis is a state of life-threatening organ dysfunction in the setting of infection. It is biologically heterogeneous, as evidenced by whole blood transcriptomic analyses that reveal distinct molecular subtypes...