Pre-existing systemic inflammation impairs bacterial clearance in the spleen [0.03%]
脾脏清除细菌的能力受全身炎症的影响
Katja Hanslin,Paul Skorup,Frida Wilske et al.
Katja Hanslin et al.
Background: Sepsis-induced immunosuppression impairs bacterial clearance and increases mortality. Liver and spleen macrophages are an essential part of the mononuclear phagocyte system and crucial for bacterial eliminatio...
Microbial lung-to-blood translocation associates with systemic inflammation in severe pneumonia: evidence from paired plasma and lower respiratory tract metagenomics [0.03%]
重症肺炎中肺源微生物血流播散与全身炎症关联的证据：基于血浆和下呼吸道宏基因组学的配对研究
Haopu Yang,Matthew K Hensley,Vi D-B Nguyen et al.
Haopu Yang et al.
Background: Biological heterogeneity in host inflammatory responses to severe pneumonia predicts clinical outcomes and may influence the effectiveness of immunomodulatory therapy. The upstream drivers of this heterogeneit...
Impaired systemic antibody response against gut microbiota pathobionts in critical illness and susceptibility to nosocomial infections [0.03%]
重症患者对肠道微生物病原体的系统性抗体反应受损及其对医院感染的易感性
Nicole A Cho,Jared Schlechte,Ian-Ling Yu et al.
Nicole A Cho et al.
Background: Critically ill patients in intensive care units (ICUs) experience high rates of hospital-acquired (nosocomial) infections, commonly caused by translocation and dissemination of pathogenic microorganisms that c...
Georg Franz Lehner,Timo Mayerhöfer,Fabian Perschinka et al.
Georg Franz Lehner et al.
Perioperative micro-arterial function and extravasation in cytoreductive ovarian cancer surgery: an observational study [0.03%]
卵巢癌细胞减灭术中的围手术期微动脉功能和外渗的一项观察性研究
Aarne Feldheiser,Jana-Jennifer Dathe,Sandra Heinig et al.
Aarne Feldheiser et al.
Background: Patients undergoing extended multivisceral, non-cardiac surgery require a high demand for intravenous fluid administration, leading to substantial positive fluid balances. This study aimed to perioperatively c...
Machine learning-driven prediction model for successful weaning of patients from mechanical ventilation in ICU [0.03%]
基于机器学习的预测ICU患者成功脱离机械通气模型
Changcui Qiu,Lulu Tang,Yugang Zhuang et al.
Changcui Qiu et al.
Background: Mechanical ventilation is a critical life support technology in the intensive care unit. However, the weaning process remains complex, making the optimal timing for liberation from ventilation challenging to a...
Bedside detection of end-tidal overdistention: an exploratory comparison of loading maneuvers [0.03%]
潮气末过度膨胀的床旁检测：不同设置下的探索性比较研究
Rebecca L Kummer,Lauren T Thornton,John E Selickman et al.
Rebecca L Kummer et al.
Background: Paradoxical improvement in respiratory system compliance with chest wall loading ('mechanical paradox') has been well described in adult respiratory distress syndrome (ARDS), especially in the setting of sever...
Femoral vein Doppler ultrasound for assessing venous congestion and right heart function: a scoping review [0.03%]
股静脉多普勒超声评估静脉淤血和右心功能的系统综述
Rafael Hortêncio Melo,Adrian Wong,Abhilash Koratala et al.
Rafael Hortêncio Melo et al.
Introduction: Venous congestion is a major contributor to organ dysfunction in critically ill and perioperative patients. While Doppler-based ultrasound strategies such as VExUS are the focus of growing clinical and resea...
Direct RNA sequencing identified solute carrier family 2 member 1 to improve neurological outcome prediction after cardiac arrest [0.03%]
直接RNA测序鉴定出溶质载体家族成员SCL2A1可改善心脏骤停后神经预后的预测能力
Victoria Stopa,Miron Sopic,Lu Zhang et al.
Victoria Stopa et al.
Background: Cardiac arrest (CA) is a major cause of mortality and morbidity. Accurate prediction of neurological outcome and survival remains challenging. In this context, our study aimed to explore novel molecular biomar...
The effect of dexmedetomidine on rocuronium-induced neuromuscular blockade and its reversal by sugammadex [0.03%]
舒更葡糖钠对瑞库溴铵引起的神经肌肉阻滞及拮抗作用的影响研究dexmedetomidine的效果
Marianna Fedor,Nikolett Sallai,Béla Fülesdi et al.
Marianna Fedor et al.
Background: Dexmedetomidine (DEX) is increasingly used in the intensive care unit for sedation and also serves as an adjuvant in general anesthesia and in procedural sedations. We tested whether dexmedetomidine at differe...