Animal models of critical care illnesses: current reality, future directions [0.03%]
危重病动物模型的研究：现状和未来方向
John F Fraser,Shigeaki Inoue,Yongming Yao et al.
John F Fraser et al.
Citrate regional anticoagulation of 500 ml/min of extracorporeal blood flow: an experimental study [0.03%]
枸橼酸抗凝下体外血液循环流量达500ml/(min·kg)的实验研究
Sebastiano Maria Colombo,Luigi Vivona,Michele Battistin et al.
Sebastiano Maria Colombo et al.
Background: Regional citrate anticoagulation (RCA) is the most widespread technique which allows to perform extracorporeal treatments, avoiding the complications of systemic anticoagulation. Due to limited citrate clearan...
Physiology, imaging and proteomics of non-ventilated vs. non-perfused lung injury: an experimental study [0.03%]
无灌注和无通气性肺损伤的生理学、影像学和蛋白质组学研究：一项实验研究
Anna Damia,Ines Marongiu,Elena Spinelli et al.
Anna Damia et al.
Background: The exclusion of one lung from ventilation or pulmonary artery perfusion triggers pathological mechanisms that can lead to lung injury. Although the final effect is similar for both insults, the underlying mec...
Left ventricular systolic longitudinal strain in mechanically ventilated patients in the intensive care unit: assessment of global and chamber reproducibility [0.03%]
机械通气患者的左心室收缩纵向应变：全局和心腔再现性的评估
Matías Pécora,Piero Pastorini,Roberto Farolini et al.
Matías Pécora et al.
Introduction: In the intensive care unit (ICU), left ventricular systolic function is traditionally assessed by measuring the left ventricular ejection fraction (LVEF). Recently, left ventricular global systolic longitudi...
Advancing omics technologies in acute respiratory distress syndrome: paving the way for personalized medicine [0.03%]
急性呼吸窘迫综合征的组学技术进展：为个性化医学铺平道路
Lou&#x;i Al-Husinat,Mohammad Araydah,Sarah Al Sharie et al.
Lou&#x;i Al-Husinat et al.
Despite advances in critical care, acute respiratory distress syndrome (ARDS) remains a potentially life-threatening condition with high mortality. The heterogeneous nature of ARDS, caused by diverse etiologies, poses considerable challenge...
Prediction of lung overdistension during mechanical ventilation using micro-RNA and gene expression [0.03%]
预测机械通气过程中的肺过度膨胀的microRNA和基因表达模型
Cecilia López-Martínez,Paula Martín-Vicente,Laura Amado-Rodríguez et al.
Cecilia López-Martínez et al.
Background: Overstretching of lung parenchyma may lead to injury, especially during mechanical ventilation. To date, there are no specific biomarkers of lung stretch, but transcriptomic signatures have not been explored. ...
Sub-phenotyping in critical care: a valuable strategy or methodologically fragile path? [0.03%]
重症监护下的亚分型：一种有价值的策略还是脆弱的方法学路径？
Jim M Smit,Annemijn H Jonkman,Jesse H Krijthe
Jim M Smit
Intensive care infection score: ICIS discriminates between infected and uninfected critically ill patients in routine intensive care unit practice [0.03%]
重症监护感染评分：ICIS能够区分常规重症监护病房收治的感染与未感染重症患者
Emre Deniz,Stefanie Klatte,Nilgün Tekin-Bubenheim et al.
Emre Deniz et al.
Background: Diagnosis of infectious inflammation is challenging as acute phase protein expression is nonspecific, limiting the utility of well-established biomarkers, such as procalcitonin (PCT) and C-reactive protein (CR...
In vitro and in vivo muscle mass and strength during the first week of critical illness [0.03%]
危重疾病第一周的体外和体内肌肉质量和力量的变化
Wout J Claassen,Isabel M van Ruijven,Marloes van den Berg et al.
Wout J Claassen et al.
Background: Loss of muscle mass and strength is provoked by critical illness. Our primary aim was to study the development of muscle atrophy and weakness in vitro in isolated myofibers and in vivo muscle mass and in vitro...
Explainable machine learning models for mortality prediction in patients with sepsis in tertiary care hospital ICU in low- to middle-income countries [0.03%]
适用于低收入和中等收入国家三级医院ICU的脓毒症患者的可解释机器学习死亡率预测模型
Saumya Diwan,Vinay Gandhi,Esha Baidya Kayal et al.
Saumya Diwan et al.
Introduction: Mortality in sepsis patients remains a challenging condition due to its complex nature. It is an even more prevalent health problem in low- and middle-income countries demanding costly treatment and manageme...