When controls are healthy: the difficulty of testing neuroprotection in low-injury models [0.03%]
当控组良好的情况：在低损伤模型中测试神经保护作用的困难性
Wilhelm Behringer,Benjamin Abella,Jasmin Arrich et al.
Wilhelm Behringer et al.
Effect of lateral positioning on ventilation in patients with blunt thoracic injury during pressure support ventilation: the VICTORY study [0.03%]
受伤胸部患者在压力支持通气期间侧卧位对通气的影响：VICTORY研究
Vorakamol Phoophiboon,Antenor Rodrigues,Matthew Ko et al.
Vorakamol Phoophiboon et al.
Background: In patients with blunt thoracic injury requiring mechanical ventilation lateral positioning is routinely performed. Whether it modifies ventilation distribution and aeration is unclear. ...
Current rat models of extracorporeal life support following global ischaemia: a scoping review [0.03%]
全脑缺血后体外生命支持的大鼠模型的系统评价
Johannes Dinkelaker,Jan-Steffen Pooth,Georg Trummer et al.
Johannes Dinkelaker et al.
Introduction: Small animal models are indispensable in cardiovascular research. This scoping review aims to provide an overview of contemporary rat models for extracorporeal life support (ECLS) after global ischaemia. ...
Comparison of two different recruitment maneuver patterns in ARDS patients [0.03%]
两种不同 recruitmaneuver模式在ARDS患者中的比较研究
Davide Chiumello,Marialaura Montante,Pedro Wendel Garcia et al.
Davide Chiumello et al.
Background: The differential effects of the two most commonly investigated recruitment maneuvers (RMs), i.e., sigh recruitment and sustained inflation, have not been fully investigated yet. This study aimed to compare the...
The impact of lipid-rich nutrition on ketogenesis and muscle weakness in sepsis [0.03%]
脂质丰富营养对脓毒症酮体生成和肌肉力量的影响
Caroline Lauwers,Jan Gunst,Soraya El Dawy et al.
Caroline Lauwers et al.
Background: Administration of ketone bodies attenuated the severity of sepsis-induced muscle weakness in preclinical studies. Whether lipid-rich emulsions may likewise mitigate such muscle weakness by stimulating the endo...
Time-series clustering analysis reveals distinct patterns of cytomegalovirus viremia in critically ill adults [0.03%]
时间序列聚类分析揭示了重症成人巨细胞病毒血症的模式
Jan-Hendrik Naendrup,Oliver Martin Hilbers,Henning Gruell et al.
Jan-Hendrik Naendrup et al.
Background: Critically ill patients are at increased risk for cytomegalovirus (CMV) reactivation, which is associated with poorer clinical outcomes. However, little is known about the longitudinal viremia trajectories in ...
Renin-angiotensin system activation and oxidative stress in hospitalized COVID-19 patients: a single-centre prospective observational study [0.03%]
住院COVID-19患者肾素血管紧张素系统激活与氧化应激的一项单中心前瞻性观察研究
Davide Eleuteri,Filippo Del Tedesco,Federico Silvia et al.
Davide Eleuteri et al.
Background: The renin-angiotensin system (RAS) plays a critical role in vascular homeostasis and inflammation, and its dysregulation has been implicated in the pathophysiology of COVID-19. We investigated the dynamics of ...
Immune dysregulation through longitudinal lymphocyte trajectories and their clinical determinants in hospitalized COVID-19 patients [0.03%]
住院COVID-19患者的纵向淋巴细胞轨迹及其临床决定因素导致免疫失调
José Pedro Cidade,Fabio Silvio Taccone,Luis Felipe Reyes et al.
José Pedro Cidade et al.
Objective: Immune dysregulation plays a pivotal role in the pathophysiology of sepsis and COVID-19, with lymphopenia emerging as a consistent marker of severity and poor prognosis. However, most existing studies have asse...
Albumin kinetics, intravascular fluid volume, and respiratory function in pigs ventilated at different levels of mechanical power following crystalloid vs. albumin infusion [0.03%]
晶体液与白蛋白输注对不同机械通气功率所致呼吸功能障碍的血清白蛋白动力学及血管内容量的影响
Simone Gattarello,Gaetano Gazzé,Emanuele Rollo et al.
Simone Gattarello et al.
Background: The rationale of albumin use lies in its potential to increase oncotic pressure and optimize tissue perfusion. Randomized trials have not demonstrated a survival benefit, and the effects of albumin on volemia ...
The therapeutic potential of high-dose inhaled nitric oxide for antimicrobial effects: a narrative review and future directions [0.03%]
高剂量吸入一氧化氮的抗菌潜力：综述与未来方向
Lorenzo Berra,Nikolay Kamenshchikov,Asher Tal et al.
Lorenzo Berra et al.
Inhaled nitric oxide (iNO), long used as a selective pulmonary vasodilator, has demonstrated potential antimicrobial and antiviral properties when administered at high concentrations (> 20 parts per million, ppm). While definitive evidence ...