Innovation in sepsis trials: rethinking endpoints, statistics and patient stratification [0.03%]
创新的脓毒症试验：重新思考终点、统计和患者分层
Sascha David,Marc Leone,Massimo Girardis et al.
Sascha David et al.
Despite extensive research, effective causal therapies for sepsis remain elusive, highlighting a persistent translational gap between biological understanding and clinical outcomes. Traditional randomised clinical trials (RCTs) have largely...
Evaluation of plasma calprotectin as a marker for infection in various clinical settings: a prospective observational study [0.03%]
评估血浆Calprotectin在不同临床环境中的感染标志物价值：一项前瞻性观察研究
Tobias Zimmermann,Timothy Arthur Chandos Snow,Pedro Lopez-Ayala et al.
Tobias Zimmermann et al.
Background: Reliably distinguishing infection from sterile inflammation is a major clinical challenge. Uncertainty can lead to unnecessary courses of antibiotics, fueling antimicrobial resistance and adverse effects. Calp...
Identification of physiological clusters in acute hypoxemic respiratory failure patients undergoing non-invasive respiratory support using EIT-based t-SNE and spectral clustering [0.03%]
基于EIT的t-SNE和谱系聚类在急性低氧性呼吸衰竭非侵入性呼吸支持患者生理分类中的应用识别
Gaetano Scaramuzzo,Valentina Bellini,Matteo Trevisani et al.
Gaetano Scaramuzzo et al.
Purpose: Identifying physiological clusters in acute hypoxemic respiratory failure (AHRF) may help to personalize non-invasive respiratory support (NIRS). Electrical impedance tomography (EIT) provides real-time, regional...
Impact of air pollution on exacerbations of respiratory and cardiovascular diseases for the intensivist: a narrative review [0.03%]
空气污染对呼吸和心血管系统疾病加重的影响：一篇针对重症监护医生的综述文章
Alexandre Gaudet,Charlotte Lacombe,Gaetan Piga et al.
Alexandre Gaudet et al.
Air pollution is a major global health threat, yet its specific impact on critically ill patients remains underexplored. While the link between air pollution and respiratory and cardiovascular events is well-documented, its contribution to ...
The lung in acute respiratory failure: insights from synchrotron radiation imaging [0.03%]
急性呼吸衰竭时的肺：来自同步辐射成像的见解
Sam Bayat,Gergely Albu,Luca Fardin et al.
Sam Bayat et al.
Acute respiratory failure and the acute respiratory distress syndrome (ARDS) are characterized by profound spatial and temporal heterogeneity in lung aeration, mechanics, and inflammation. While mechanical ventilation is often vital to ensu...
Post-treatment with H12-(ADP)-liposomes after LPS challenge ameliorated coagulopathy and critical organ injury in rats [0.03%]
LPS攻击后采用H12-(ADP)-脂质体处理改善大鼠凝血障碍和重要脏器损伤
Kohsuke Hagisawa,Osamu Ishida,Hiroyuki Nakashima et al.
Kohsuke Hagisawa et al.
Background: Liposomes coated with fibrinogen γ-chain (HHLGGAKQAGDV, H12) peptide and encapsulating adenosine-diphosphate (ADP) [H12-(ADP)-liposomes] can augment platelet aggregation via glycoprotein IIb/IIIa receptors di...
Role and modulation of perioperative stress response to improve outcomes [0.03%]
围术期应激反应的作用及其调控对术后康复的影响
Aarne Feldheiser,Nandor Marczin
Aarne Feldheiser
Improving retrospective ARDS case-finding using a simple 72-h physiologic persistence rule [0.03%]
使用简单的72小时生理持续性规则改进回顾性ARDS病例发现能力
Dominic C Marshall,Brijesh V Patel,Anthony C Gordon et al.
Dominic C Marshall et al.
Background: Retrospective studies frequently use single-time-point Berlin physiologic criteria (PaO2/FiO2 < 300 mm Hg plus positive end-expiratory pressure ≥ 5 cm H2O) to identify acute respiratory distress syndrome (ARD...
Personalised viscoelastometry-guided systemic thrombolysis for high- and intermediate-high-risk acute pulmonary embolism in the ICU: a single-centre randomised controlled interventional feasibility trial [0.03%]
针对ICU高危和中高危急性肺栓塞患者的个性化血栓弹性和全身溶栓治疗的单中心随机对照干预可行性试验
András Kállai,Anna Párkányi,Máté Berczi et al.
András Kállai et al.
Background: Systemic thrombolysis is recommended for high-risk pulmonary embolism, but is associated with a substantial bleeding risk due to thrombolysis-induced coagulopathy. However, recent advances in precision and per...
Potential role of extracellular vesicles in bacterial phagocytosis during Escherichia coli pneumonia in ex vivo perfused human lungs [0.03%]
气溶胶在人体外灌注肺埃希氏大肠杆菌肺炎细菌吞噬作用中的潜在作用
Hongli He,Shinji Sugita,Qi Hao et al.
Hongli He et al.
Background: Plasma extracellular vesicles (EV) play an inflammatory role in bacterial pneumonia. This study aimed to determine if plasma EVs could be manipulated to reduce lung injury. We hypothesized that inhibition of m...