Selective hemoadsorption of cytokines and platelet-neutrophil complexes mitigates lung microvascular hyperpermeability in an ovine acute lung injury model [0.03%]
选择性血细胞吸附清除细胞因子和血小板-中性粒细胞复合物可减轻绵羊急性肺损伤模型的肺微血管高通透性
Satoshi Fukuda,Yosuke Niimi,Yumiko Sekiya et al.
Satoshi Fukuda et al.
Background: Acute respiratory distress syndrome (ARDS) is a life-threatening disease that is characterized by noncardiogenic pulmonary edema, respiratory distress, and hypoxemia, and has high mortality. Uncontrolled activ...
Association between VExUS score and worsening renal function during diuretic therapy in the ICU [0.03%]
VExUS评分与ICU利尿治疗期间肾功能恶化之间的关系
Corentin Evezard,Pierre Alain Bahr,Maxime Nguyen et al.
Corentin Evezard et al.
Background: In intensive care unit (ICU) settings, venous excess ultrasound (VExUS) score has gained attention for predicting Acute Kidney Injury (AKI). This led to the identification that venous congestion via VExUS shou...
A new murine gram-negative sepsis model with standard care satisfies Sepsis-3 and reproduces clinical pathology [0.03%]
一个接受标准治疗的新鼠源革兰阴性脓毒症模型符合Sepsis-3并重现临床病理状况
Cameron R Bastow,Cynthia Mei,Shu Wen Wen et al.
Cameron R Bastow et al.
Background: Sepsis accounts for approximately a third of global mortality, and significant morbidity and economic burden. Whilst the current Sepsis-3 definition has augmented patient identification, supportive care and su...
Characterizing heterogeneity and subphenotyping acute respiratory distress syndrome with computed tomography [0.03%]
急性呼吸窘迫综合征的CT异质性分析及亚表型分层研究
Roberta Garberi,Matthieu Jabaudon,Sam Bayat et al.
Roberta Garberi et al.
Acute respiratory distress syndrome (ARDS) is a heterogeneous clinical syndrome rather than a single disease. Patients who meet the same diagnostic criteria may differ in lung morphology, mechanical properties, biological injury, and clinic...
Setting PEEP in patients with COVID-19-related ARDS: a physiological comparison between methods [0.03%]
COVID-19相关性ARDS患者PEEP设置的生理学比较方法研究
Dolf Weller,Peter Somhorst,Corstiaan den Uil et al.
Dolf Weller et al.
Background: Several approaches for setting PEEP in patients with (COVID-19-related) ARDS have been proposed. It is unclear whether a best approach exist, and how the recommended PEEP and resulting transpulmonary pressure,...
Physiological dissociation between ventilatory ratio and ventilatory efficiency in patients with ARDS [0.03%]
成人ARDS患者通气比和通气效率的生理分离现象研究
Martín H Benites,Fernando Suarez-Sipmann,Arnoldo Santos et al.
Martín H Benites et al.
Background: The ventilatory ratio (VR) is frequently used as a surrogate marker of ventilatory efficiency in patients with ARDS. However, its ability to reflect changes in alveolar ventilation (V̇Talv/VT) when respirator...
Prediction-guided clustering for sepsis phenotyping: a retrospective cohort analysis [0.03%]
预测指导的脓毒症表型聚类分析：回顾性队列研究
Paul A Hilders,Lada Lijović,Martijn Otten et al.
Paul A Hilders et al.
Background: Sepsis is a major cause of morbidity and mortality worldwide, with its heterogeneous and dynamically evolving clinical presentation complicating diagnosis, treatment, and prognosis. The identification of clini...
The impact of metabolic syndrome on regional ventilation and perfusion in ARDS: an observational cohort study using electrical impedance tomography [0.03%]
代谢综合征对ARDS局部通气与灌注的影响：一项采用电阻抗断层扫描的队列观察研究
Timothy G Gaulton,Marcus Victor,Glasiele Alcala et al.
Timothy G Gaulton et al.
Background: Acute Respiratory Distress Syndrome (ARDS) is characterized by severe hypoxemia from heterogeneous impairments in regional ventilation and perfusion. Metabolic syndrome, a combination of central obesity, insul...
Clinical practice in using corticosteroids and adjunctive sepsis therapies at the bedside among European ICUs: an ESICM-endorsed survey [0.03%]
欧洲ICU皮质类固醇和抗感染药物临床应用的调查研究
Sascha David,Marc Leone,Massimo Girardis et al.
Sascha David et al.
Background: Sepsis and septic shock remain major causes of morbidity and mortality worldwide, and management is largely based on source control, antimicrobial therapy, and supportive care. Despite limited high-quality evi...
Endotoxemia and its association with immune and coagulopathy responses in severe community-acquired pneumonia and COVID-19 [0.03%]
内毒素血症与社区获得性肺炎和新型冠状病毒肺炎重症免疫及凝血反应的关系
Mathieu Blot,Amadou-Khalilou Sow,David Masson et al.
Mathieu Blot et al.
Background: Acute community-acquired pneumonia (CAP) is a leading cause of infection-related mortality worldwide. Endotoxemia, characterized by elevated plasma lipopolysaccharide (LPS), is a key driver of inflammation and...