Total liquid ventilation in a porcine model of severe acute respiratory distress syndrome using a new generation of liquid ventilator [0.03%]
一种新型液体通气机在重度急性呼吸窘迫综合征猪模型中进行完全液体通气的研究
Naoto Watanabe,Antoine Bois,Fanny Lidouren et al.
Naoto Watanabe et al.
Background: Total liquid ventilation (TLV) has been experimentally proposed as an alternative treatment for the management of Acute Respiratory Distress Syndrome (ARDS). Recent technological advances have led to the evalu...
Gas as medicine: the case for hydrogen gas as a therapeutic agent for critical illness [0.03%]
气体作为药物：氢气作为危重疾病治疗剂的可行性研究
Lakhmir S Chawla
Lakhmir S Chawla
Molecular hydrogen gas (HG), administered through inhalation or as hydrogen-rich fluids (HRF), has demonstrated antioxidant, anti-inflammatory, antiapoptotic, cytoprotective, and beneficial mitochondrial effects in critical illness. Preclin...
Regional venous-to-arterial carbon dioxide pressure and content differences during endotoxemic shock: influence of hydrogen ion accumulation vs. Haldane effect [0.03%]
内毒素性休克时的区域静脉至动脉二氧化碳分压和含量差：氢离子蓄积与汉德安效应的影响
Gustavo A Ospina-Tascón,Daniel De Backer,José L Aldana et al.
Gustavo A Ospina-Tascón et al.
Background: The relationship between carbon dioxide pressures (PCO2) and contents (CCO2) is linked to the Haldane effect. Nevertheless, under shock conditions, hydrogen ion accumulation might strongly influence the discre...
Uncovering molecular markers of the microvascular endothelial response in sepsis-associated acute kidney injury: a translational study in mice and humans [0.03%]
用于急性肾损伤的微观血管内皮反应的分子标志物的发现：小鼠和人类中的转化研究
T J van der Aart,G Molema,R M Jongman et al.
T J van der Aart et al.
Introduction: Endothelial cells play a central role in the pathophysiology of sepsis-associated acute kidney injury (SA-AKI), yet we have limited understanding of the markers of microvascular-specific response. We therefo...
Comparison of changes in arterial blood pressure and cardiac output during cardiogenic shock development in a porcine model [0.03%]
猪模型中心源性休克发展过程中动脉血压和心排血量变化的比较
Laura Svanekjaer,Jeppe K P Larsen,Peter H Frederiksen et al.
Laura Svanekjaer et al.
Background: Low systolic blood pressure (SBP) is a key criterion for diagnosing cardiogenic shock (CS) caused by a reduction in stroke volume and cardiac output (CO). The temporal interaction between changes in pressure a...
Serum biomarkers of delirium in critical illness: a systematic review of mechanistic and diagnostic evidence [0.03%]
重症监护下谵妄的血清生物标志物：机制和诊断证据的系统回顾
Fergus O&#x;Keeffe,Isolde Cervoni,Mario Ganau et al.
Fergus O&#x;Keeffe et al.
Delirium is a frequent and serious complication of critical illness, yet its pathophysiological mechanisms remain incompletely understood. Serum biomarkers offer a potential avenue for improved diagnosis, risk stratification, and mechanisti...
Lorenzo Calabró,Filippo Annoni,Fabio Silvio Taccone
Lorenzo Calabró
Dobutamine is the most commonly used inotropic agent in critically ill patients with impaired cardiac contractility. However, its benefit-risk profile remains debated, and clear, structured guidance for its use is lacking. This hypothesis p...
Gut microbiota differs between ICU patients admitted for cardiac arrest and other causes: a secondary, propensity-matched cohort analysis [0.03%]
重症监护病房因心搏骤停和其它原因入院患者的肠道微生物群存在差异：一项次要的倾向匹配队列分析
Hannah Wozniak,Eleonora Balzani,Vladimir Lazarevic et al.
Hannah Wozniak et al.
Background: Critical illness is known to reduce gut microbiota (GM) diversity, a change associated with adverse outcomes. Among potential mechanisms, splanchnic hypoperfusion may play a key role. Cardiac arrest (CA), char...
Free water improves sodium mobilization in furosemide treated pigs after a hyperosmotic sodium load [0.03%]
自由水摄入可改善呋塞米处理的猪在高渗性钠负荷后的钠动员情况
Annelie Barrueta Tenhunen,Anders Larsson,Olav Rooyackers et al.
Annelie Barrueta Tenhunen et al.
Background: Hypernatremia, a common electrolyte disorder in critically ill patients, induces a hyperosmotic state linked to increased mortality and metabolic stress. While loop diuretics such as furosemide are used for fl...
A phase I trial evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of intravenously administered low-anticoagulant heparin (M6229) in critically ill sepsis patients [0.03%]
低抗凝肝素（M6229）静脉注射治疗重症脓毒症患者的安全性、耐受性和药代动力学及药效学I期临床试验
Niels van Mourik,Rombout B E van Amstel,Marleen A Slim et al.
Niels van Mourik et al.
Background: Histones released in response to cellular injury are important mediators of organ failure and death in sepsis. Preclinical studies demonstrate that neutralization of histones in sepsis is associated with impro...