Behaviour artificial intelligence technology to support the decision-making process of continuation or withdrawal of life-sustaining therapy [0.03%]
行为人工智能技术在支持维持生命治疗延续或撤除决策中的作用
Patrick J Thoral,Jesse de Metz,Stella Mulia et al.
Patrick J Thoral et al.
Background: Withholding and withdrawing life-sustaining therapy (LST) is common in European ICUs but significant variations exist. Behaviour artificial intelligence technology (BAIT) may help standardize the ethical dilem...
Continuous intratracheal gas suctioning combined with ventilator leak-compensation may enhance carbon dioxide removal efficiency: a proof-of-concept study using a porcine model [0.03%]
持续性支气管吸氧联合呼吸机漏气回补或可增强二氧化碳清除效率：猪模型概念验证研究
Norihiko Tsuboi,Kaoru Tsuboi,Shin Tsubokura et al.
Norihiko Tsuboi et al.
Background: Although tracheal gas insufflation (TGI) and aspiration of expiratory gas in the dead space (ASPIDS) have been shown to enhance CO₂ removal by washing out the anatomical dead space, clinical implementation ha...
Timing-dependent renal protection of dapagliflozin in endotoxemic diabetic mice by real-time GFR and biomarkers [0.03%]
基于实时肾小球滤过率和生物标志物的达格列净在内毒素血症糖尿病小鼠中的时间依赖性肾脏保护作用研究
Yu Xiao,Lifeng Shen,Yuchen Song et al.
Yu Xiao et al.
Introduction: Type 2 diabetes mellitus (T2DM) increases susceptibility to sepsis-associated acute kidney injury (SA-AKI). While guidelines support chronic sodium-glucose cotransporter 2 (SGLT2) inhibitor use in T2DM, thei...
Improving mortality prediction in critically ill cancer patients with a multidimensional machine learning model [0.03%]
基于多维度机器学习模型改善重症癌症患者的死亡率预测
Víctor H Nieto,Adriana C Aya,Andrés F Cardona et al.
Víctor H Nieto et al.
Background: Prognostic assessment in critically ill cancer patients is challenging due to the suboptimal performance of traditional severity scores. We developed and validated machine learning models to provide an objecti...
Mouse models to study von Willebrand factor in inflammation: a scoping review [0.03%]
用于炎症研究von Willebrand因子的小鼠模型：综述性文章
Hassan Masood,Veronica DeYoung,Peter Andrisani et al.
Hassan Masood et al.
Background: VWF is released from activated endothelial cells and activated platelets in response to vascular injury, and is now recognized as an important contributor to a growing number of inflammatory conditions. This s...
Kirsten A Kalverda,Lizzy Wijmans,Lieuwe D J Bos et al.
Kirsten A Kalverda et al.
Background: Survivors of the early exudative phase of acute respiratory distress syndrome (ARDS) may develop a fibroproliferative repair response and persistent microstructural remodeling associated with adverse outcomes....
Source-controlled bacterial peritonitis improves survival but leaves persistent lung inflammation and airway IgA loss [0.03%]
病原菌控制的腹膜炎能提高生存率但会导致持续性肺部炎症和分泌型IgA水平降低
Azusa Kato,Masafumi Saito,Hiromi Miyazaki et al.
Azusa Kato et al.
Background: Cecal ligation and puncture (CLP) is widely used to develop polymicrobial sepsis model in rodents, yet conventional CLP is not advantageous for evaluating long-term outcomes because most animals succumb withou...
Noradrenaline-trajectory phenotypes in septic shock: derivation and external validation in two independent cohorts [0.03%]
脓毒性休克中的去甲肾上腺素反应表型：在两个独立队列中推导和外部验证
Gargi Yonatan,Amir Cohen,Dorit Stein et al.
Gargi Yonatan et al.
Background: Septic shock is heterogeneous, and noradrenaline (NA) requirements evolve over time in ways that reflect vascular responsiveness and shock biology. Whether long-horizon NA dose-trajectory phenotypes are reprod...
Exploratory dose modeling of hemoadsorption in pediatric septic shock [0.03%]
探索性剂量模型在儿童脓毒性休克血液吸附中的应用
Gabriella Bottari
Gabriella Bottari
Background: Clinical outcomes of hemoadsorption (HA) in sepsis remain uncertain despite demonstrated biological efficacy in in vivo models. Persistent knowledge gaps concern both patient selection-now increasingly interpr...
Sex-related differences in lung injury distribution and outcomes in COVID-19 acute respiratory failure: insights from the CT-COVID19 multicenter study group [0.03%]
CT-COVID19多中心研究组关于Covid-19急性呼吸衰竭中肺损伤分布及预后的性别差异性分析
Davide Signori,Alice Nova,Yi Xin et al.
Davide Signori et al.
Background: Sex-related differences have been consistently reported in the epidemiology of acute hypoxemic respiratory failure (AHRF) and COVID-19. However, whether computed tomography (CT)-derived measures of lung injury...