The lung in acute respiratory failure: insights from synchrotron radiation imaging [0.03%]
急性呼吸衰竭时的肺：来自同步辐射成像的见解
Sam Bayat,Gergely Albu,Luca Fardin et al.
Sam Bayat et al.
Acute respiratory failure and the acute respiratory distress syndrome (ARDS) are characterized by profound spatial and temporal heterogeneity in lung aeration, mechanics, and inflammation. While mechanical ventilation is often vital to ensu...
Post-treatment with H12-(ADP)-liposomes after LPS challenge ameliorated coagulopathy and critical organ injury in rats [0.03%]
LPS攻击后采用H12-(ADP)-脂质体处理改善大鼠凝血障碍和重要脏器损伤
Kohsuke Hagisawa,Osamu Ishida,Hiroyuki Nakashima et al.
Kohsuke Hagisawa et al.
Background: Liposomes coated with fibrinogen γ-chain (HHLGGAKQAGDV, H12) peptide and encapsulating adenosine-diphosphate (ADP) [H12-(ADP)-liposomes] can augment platelet aggregation via glycoprotein IIb/IIIa receptors di...
Role and modulation of perioperative stress response to improve outcomes [0.03%]
围术期应激反应的作用及其调控对术后康复的影响
Aarne Feldheiser,Nandor Marczin
Aarne Feldheiser
Improving retrospective ARDS case-finding using a simple 72-h physiologic persistence rule [0.03%]
使用简单的72小时生理持续性规则改进回顾性ARDS病例发现能力
Dominic C Marshall,Brijesh V Patel,Anthony C Gordon et al.
Dominic C Marshall et al.
Background: Retrospective studies frequently use single-time-point Berlin physiologic criteria (PaO2/FiO2 < 300 mm Hg plus positive end-expiratory pressure ≥ 5 cm H2O) to identify acute respiratory distress syndrome (ARD...
Personalised viscoelastometry-guided systemic thrombolysis for high- and intermediate-high-risk acute pulmonary embolism in the ICU: a single-centre randomised controlled interventional feasibility trial [0.03%]
针对ICU高危和中高危急性肺栓塞患者的个性化血栓弹性和全身溶栓治疗的单中心随机对照干预可行性试验
András Kállai,Anna Párkányi,Máté Berczi et al.
András Kállai et al.
Background: Systemic thrombolysis is recommended for high-risk pulmonary embolism, but is associated with a substantial bleeding risk due to thrombolysis-induced coagulopathy. However, recent advances in precision and per...
Potential role of extracellular vesicles in bacterial phagocytosis during Escherichia coli pneumonia in ex vivo perfused human lungs [0.03%]
气溶胶在人体外灌注肺埃希氏大肠杆菌肺炎细菌吞噬作用中的潜在作用
Hongli He,Shinji Sugita,Qi Hao et al.
Hongli He et al.
Background: Plasma extracellular vesicles (EV) play an inflammatory role in bacterial pneumonia. This study aimed to determine if plasma EVs could be manipulated to reduce lung injury. We hypothesized that inhibition of m...
Stéphanie Pons,Morgane Grosset,Emmanuelle Touze et al.
Stéphanie Pons et al.
Haematological malignancies (HMs) are characterized by profound immune dysregulation, which increases susceptibility to sepsis. This dysregulation arises from the underlying disease and may be exacerbated by treatments. Sepsis itself induce...
Thermocycling: enhancing efficiency of anesthetic reflectors through cyclic heating and cooling-finding the optimal temperature in a bench study [0.03%]
热循环：通过周期性加热和冷却提高麻醉反射器的效率-在实验台研究中寻找最佳温度
Frederic Albrecht,Kathrin Scheffler,David Kellner et al.
Frederic Albrecht et al.
Background: Volatile anesthetics are widely used for sedation in intensive care. Being potent greenhouse gases, their efficient utilization is imperative. We investigated whether the efficiency of anesthetic reflection de...
Comparison of norepinephrine with a combined non-catecholaminergic therapy in a porcine model of refractory cardiac arrest resuscitated with VA-ECMO [0.03%]
与使用VA-ECMO复苏的难治性心脏骤停猪模型中比较去甲肾上腺素和非拟交感胺类联合治疗的效果
Thomas Klein,Vincent Elsensohn,Mathilde Martin-Schouler et al.
Thomas Klein et al.
Introduction: Post-cardiac arrest syndrome (PCAS) under veno-arterial ECMO (VA-ECMO) is frequently complicated by severe vasoplegia and microcirculation failure. Conventional resuscitation relies heavily on catecholamines...
Speed of intravenous fluid on glycocalyx integrity and central blood volume in a porcine septic shock model [0.03%]
静脉输液速度对糖萼完整性和内脏血液容量在猪感染性休克模型中的影响
Yosef Levenbrown,Md Jobayer Hossain,Paul T Fawcett et al.
Yosef Levenbrown et al.
Background: It is unclear whether the rate of intravenous fluid (IVF) administration in sepsis influences glycocalyx breakdown. This study aimed to measure the effect of rapid versus slow fluid bolus in a septic pig model...