Hepatic and intestinal microcirculation and pulmonary inflammation in a model of veno-venous extracorporeal membrane oxygenation in the rat [0.03%]
大鼠静脉-静脉体外膜氧合模型中的肝肠微循环及肺部炎症反应
Fabian Edinger,Thomas Zajonz,Nico Mayer et al.
Fabian Edinger et al.
Background: Veno-venous (V-V) extracorporeal membrane oxygenation (ECMO) is widely used in critical care but remains associated with high mortality rates (22-68%). In septic shock, increased pulmonary inflammation and imp...
Effect of low bicarbonate substitution solution on CO2 removal rate in the combined system of extracorporeal CO2 removal and continuous renal replacement therapy [0.03%]
低碳酸氢盐置换液对体外二氧化碳清除与连续性肾脏替代疗法联合系统中CO2清除率的影响
Zhicheng Qian,Rui Zhang,Yuxuan Wang et al.
Zhicheng Qian et al.
Background: The concurrent application of extracorporeal carbon dioxide removal (ECCO₂R) and continuous renal replacement therapy (CRRT) delivers essential respiratory and renal support. However, the use of bicarbonate (...
Reversible impairment of non-invasively assessed mitochondrial oxygen metabolism in the long-term course of patients with sepsis: a prospective monocentric cohort study [0.03%]
长期脓毒症患者非侵入性评估的线粒体氧代谢可逆性损伤：前瞻性单中心队列研究
Anne Standke,Charles Neu,Philipp Baumbach et al.
Anne Standke et al.
Background: Sepsis is characterized by organ dysfunction due to infection, with increasing evidence of mitochondrial dysfunction assessed preclinically and invasively. Protoporphyrin IX-triplet state lifetime technique (P...
Unravelling the complex inflammatory landscape of COVID-19 infection: a pathway to biomarkers identification in infection-associated delirium in the ICU [0.03%]
解析COVID-19感染复杂的炎症图谱：在ICU中与感染相关的谵妄生物标志物鉴定之路
Tristan Born,Matthieu Perreau,Pierre-Paul Axisa et al.
Tristan Born et al.
Background: Delirium is a serious complication in patients with COVID-19-related acute respiratory distress syndrome (ARDS) admitted to the intensive care unit (ICU). Although numerous clinical risk factors have been iden...
Establishment of a neonatal rat model of sequential hyperoxic hypoxia to recapitulate clinical progression of bronchopulmonary dysplasia-associated pulmonary hypertension [0.03%]
建立连续过氧化-低氧暴露的新生大鼠模型以模拟支气管肺发育不良相关性肺高压的临床进程
Dan Wang,Siqi Hu,Jingke Cao et al.
Dan Wang et al.
Background: Bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) seriously threatens the lives of preterm infants. The absence of animal models that can simulate its progression from early hyperoxic lung ...
Timing of inotropic support is associated with mortality in patients with acute decompensated heart failure-associated cardiogenic shock [0.03%]
正性肌力支持的时机与急性心衰相关性心源性休克患者的死亡率的关系
John C Greenwood,Charith Ratnayake,Moizza Shabbir et al.
John C Greenwood et al.
Background: Inotropic support is often used to improve hemodynamics and organ perfusion in patients with advanced heart failure-related cardiogenic shock (ADHF-CS). We aimed to evaluate the effect of inotrope timing on pa...
Lung injury promoted by strong inspiratory efforts and breath stacking: impact of ventilation mode [0.03%]
由强力吸气努力和呼吸堆积所致的肺损伤：机械通气模式的影响
Yasuhiro Norisue,Sunao Usami,Yukie Ito et al.
Yasuhiro Norisue et al.
Background: Breath stacking, particularly double triggering, is a common patient-ventilator asynchrony during strong inspiratory effort. It can cause excessive tidal volumes and high transpulmonary pressures, contributing...
The ADVanced Organ Support (ADVOS) hemodialysis system balances blood pH within 24 h in patients with multiple organ failure and hypercapnic acidosis [0.03%]
先进的器官支持系统（ADVOS）血液透析系统可在24小时内平衡多器官衰竭和高碳酸血症酸中毒患者的血液PH值
Miriam Dibos,Aritz Perez Ruiz de Garibay,Ulrich Mayr et al.
Miriam Dibos et al.
Background: Severe hypercapnia, especially when associated with acidosis, should be avoided or actively managed, as it is an independent risk factor in critically ill patients. The ADVOS multi hemodialysis system offers t...
Transesophageal lung ultrasound score is associated with arterial oxygenation and clinical outcomes in mechanically ventilated critically ill patients [0.03%]
经食道肺超声评分与机械通气危重症患者的动脉血氧合及临床结局相关性研究
Daiyin Cao,Wenliang Song,Weining Zhu et al.
Daiyin Cao et al.
Background: Transesophageal lung ultrasound (TELUS) has emerged as a novel modality that utilizes the esophageal acoustic window to obtain high-resolution images of posterior lung regions. However, its quantitative assess...
Explainable AI identifies key biomarkers for acute kidney injury prediction in the ICU [0.03%]
可解释的人工智能识别急性肾损伤的生物标志物以预测重症监护室患者的急性肾损伤
Hazem Koozi,Jonas Engström,Hans Friberg et al.
Hazem Koozi et al.
Background: Early identification of acute kidney injury (AKI) in the intensive care unit (ICU) remains challenging. We aimed to identify key predictors of new-onset AKI within 48 h after ICU admission and renal replacemen...