Recruitment of renal functional reserve by intravenous amino acid loading in a sheep model of cardiopulmonary bypass [0.03%]
静脉氨基酸输注募集慢性肾脏病绵羊心脏直视手术模型的肾功能储备
Taku Furukawa,Alemayehu H Jufar,Clive N May et al.
Taku Furukawa et al.
Background: Cardiopulmonary bypass (CPB) may decrease the renal functional reserve (RFR). However, the temporal changes in RFR after during the recovery period after CPB remains unknown. We assessed RFR before and then we...
Effect of decreasing respiratory rate on the mechanical power of ventilation and lung injury biomarkers: a randomized cross-over clinical study in COVID-19 ARDS patients [0.03%]
降低呼吸频率对机械通气做功及肺损伤生物标志物的影响：COVID-19ARDS患者的随机交叉临床试验
L Felipe Damiani,Roque Basoalto,Vanessa Oviedo et al.
L Felipe Damiani et al.
Background: The respiratory rate (RR) is a key determinant of the mechanical power of ventilation (MP). The effect of reducing the RR on MP and its potential to mitigate ventilator-induced lung injury remains unclear. ...
Immunobiological effects of tocilizumab across respiratory subphenotypes in COVID-19 ARDS [0.03%]
托珠单抗在COVID-19ARDS呼吸子表型间的免疫生物学效应
Emma Rademaker,Daan F L Filippini,Jelle L G Haitsma Mulier et al.
Emma Rademaker et al.
Background: Two distinct longitudinal respiratory subphenotypes have recently been described in COVID-19-related acute respiratory distress syndrome (ARDS). These subphenotypes exhibit dynamic immunobiological changes tha...
Edward J Schenck
Edward J Schenck
29-mRNA host response signatures for classification of bacterial infection, viral infection and disease progression in COVID-19 pneumonia: a post hoc analysis of the SAVE-MORE randomized clinical trial [0.03%]
用于区分细菌感染、病毒感染和COVID-19肺炎疾病进展的29种宿主mRNA反应特征：来自SAVE-MORE随机临床试验的事后分析
Evdoxia Kyriazopoulou,Antigone Kotsaki,Asimina Safarika et al.
Evdoxia Kyriazopoulou et al.
Background: Biomarkers based on host response signatures are currently under development for the critically ill. We applied a 29-mRNA classifier for the diagnosis and prognosis of suspected acute infection and sepsis (Tri...
Digital twins suggest a mechanistic basis for differing responses to increased flow rates during high-flow nasal cannula therapy [0.03%]
数字孪生发现了在高流量鼻导管治疗期间对流速增加的不同反应的机制基础
Hossein Shamohammadi,Sina Saffaran,Roberto Tonelli et al.
Hossein Shamohammadi et al.
Background: Inconsistent responses to increased flow rates have been observed in patients with acute hypoxemic respiratory failure (AHRF) treated with high-flow nasal cannula (HFNC) therapy, with a significant minority in...
Animal models of critical care illnesses: current reality, future directions [0.03%]
危重病动物模型的研究：现状和未来方向
John F Fraser,Shigeaki Inoue,Yongming Yao et al.
John F Fraser et al.
Citrate regional anticoagulation of 500 ml/min of extracorporeal blood flow: an experimental study [0.03%]
枸橼酸抗凝下体外血液循环流量达500ml/(min·kg)的实验研究
Sebastiano Maria Colombo,Luigi Vivona,Michele Battistin et al.
Sebastiano Maria Colombo et al.
Background: Regional citrate anticoagulation (RCA) is the most widespread technique which allows to perform extracorporeal treatments, avoiding the complications of systemic anticoagulation. Due to limited citrate clearan...
Physiology, imaging and proteomics of non-ventilated vs. non-perfused lung injury: an experimental study [0.03%]
无灌注和无通气性肺损伤的生理学、影像学和蛋白质组学研究：一项实验研究
Anna Damia,Ines Marongiu,Elena Spinelli et al.
Anna Damia et al.
Background: The exclusion of one lung from ventilation or pulmonary artery perfusion triggers pathological mechanisms that can lead to lung injury. Although the final effect is similar for both insults, the underlying mec...
Left ventricular systolic longitudinal strain in mechanically ventilated patients in the intensive care unit: assessment of global and chamber reproducibility [0.03%]
机械通气患者的左心室收缩纵向应变：全局和心腔再现性的评估
Matías Pécora,Piero Pastorini,Roberto Farolini et al.
Matías Pécora et al.
Introduction: In the intensive care unit (ICU), left ventricular systolic function is traditionally assessed by measuring the left ventricular ejection fraction (LVEF). Recently, left ventricular global systolic longitudi...