Comparison of changes in arterial blood pressure and cardiac output during cardiogenic shock development in a porcine model [0.03%]
猪模型中心源性休克发展过程中动脉血压和心排血量变化的比较
Laura Svanekjaer,Jeppe K P Larsen,Peter H Frederiksen et al.
Laura Svanekjaer et al.
Background: Low systolic blood pressure (SBP) is a key criterion for diagnosing cardiogenic shock (CS) caused by a reduction in stroke volume and cardiac output (CO). The temporal interaction between changes in pressure a...
Serum biomarkers of delirium in critical illness: a systematic review of mechanistic and diagnostic evidence [0.03%]
重症监护下谵妄的血清生物标志物：机制和诊断证据的系统回顾
Fergus O&#x;Keeffe,Isolde Cervoni,Mario Ganau et al.
Fergus O&#x;Keeffe et al.
Delirium is a frequent and serious complication of critical illness, yet its pathophysiological mechanisms remain incompletely understood. Serum biomarkers offer a potential avenue for improved diagnosis, risk stratification, and mechanisti...
Lorenzo Calabró,Filippo Annoni,Fabio Silvio Taccone
Lorenzo Calabró
Dobutamine is the most commonly used inotropic agent in critically ill patients with impaired cardiac contractility. However, its benefit-risk profile remains debated, and clear, structured guidance for its use is lacking. This hypothesis p...
Gut microbiota differs between ICU patients admitted for cardiac arrest and other causes: a secondary, propensity-matched cohort analysis [0.03%]
重症监护病房因心搏骤停和其它原因入院患者的肠道微生物群存在差异：一项次要的倾向匹配队列分析
Hannah Wozniak,Eleonora Balzani,Vladimir Lazarevic et al.
Hannah Wozniak et al.
Background: Critical illness is known to reduce gut microbiota (GM) diversity, a change associated with adverse outcomes. Among potential mechanisms, splanchnic hypoperfusion may play a key role. Cardiac arrest (CA), char...
Free water improves sodium mobilization in furosemide treated pigs after a hyperosmotic sodium load [0.03%]
自由水摄入可改善呋塞米处理的猪在高渗性钠负荷后的钠动员情况
Annelie Barrueta Tenhunen,Anders Larsson,Olav Rooyackers et al.
Annelie Barrueta Tenhunen et al.
Background: Hypernatremia, a common electrolyte disorder in critically ill patients, induces a hyperosmotic state linked to increased mortality and metabolic stress. While loop diuretics such as furosemide are used for fl...
A phase I trial evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of intravenously administered low-anticoagulant heparin (M6229) in critically ill sepsis patients [0.03%]
低抗凝肝素（M6229）静脉注射治疗重症脓毒症患者的安全性、耐受性和药代动力学及药效学I期临床试验
Niels van Mourik,Rombout B E van Amstel,Marleen A Slim et al.
Niels van Mourik et al.
Background: Histones released in response to cellular injury are important mediators of organ failure and death in sepsis. Preclinical studies demonstrate that neutralization of histones in sepsis is associated with impro...
R M J Cashmore,M Czosnyka
R M J Cashmore
Transcranial ultrasound is gaining widespread recognition as a useful bedside monitoring tool and non-invasive diagnostic device in the critically ill patient. The capabilities of transcranial ultrasound are themselves ever-increasing, and ...
Non-mechanical haemodynamic support in acute pulmonary thromboembolism: a scoping review [0.03%]
急性肺栓塞的非机械性血液动力学支持：系统综述
W Body,S Steckle,A Haggerty et al.
W Body et al.
Background and aims: Acute pulmonary thromboembolism (PE) may require haemodynamic supportive therapies while appropriate therapies for clot burden reduction are pursued. This scoping review aims to identify the non-mecha...
Effects of nebulized therapies on heat and moisture exchangers filters: a pilot study [0.03%]
雾化治疗对冷凝器的影响：一项初步研究
Florian Blanchard,Cecilia Berardi,Lucie Collet et al.
Florian Blanchard et al.
Artificial intelligence-driven decision support for patients with acute respiratory failure: a scoping review [0.03%]
急性呼吸衰竭患者的智能决策支持系统：综述研究
Preeti Gupta,Alex K Pearce,Thaidan Pham et al.
Preeti Gupta et al.
Background: Artificial intelligence (AI) has emerged as a promising tool for decision support in managing acute respiratory failure, yet its real-world clinical impact remains unclear. This scoping review identifies clini...