Electrochemical skin conductance is associated with peripheral tissue hypoperfusion in septic patients [0.03%]
电化学皮肤电导与脓毒症患者的外周组织低灌注有关
Jérémie Joffre,Tomas Urbina,Vincent Bonny et al.
Jérémie Joffre et al.
Background: Autonomic nervous system (ANS) dysfunction contributes to the pathophysiology of sepsis. However, studies using reliable methods for ANS activity monitoring and evaluating its association with outcomes in seps...
Can patient-derived in vitro models improve clinical translation in critical care research when used before animal studies? [0.03%]
患者衍生的体外模型能否在动物实验之前用于改善重症监护研究的临床转化？
Alexandre Pierre,Raphael Favory,Steve Lancel et al.
Alexandre Pierre et al.
Background: Translational failure remains a major barrier in critical illness research, with preclinical findings from animal models often failing to replicate in human trials. ...
Lipid emulsion in blood increases extraction of amitriptyline in liposome augmented peritoneal dialysis in rats chronically dosed with amitriptyline: could nanoparticles mitigate the limitations to dialysis in intoxication? [0.03%]
在慢性阿米替林暴露的大鼠中，血液中的脂质乳剂可增加含阿米替林的脂质体腹膜透析清除率：纳米颗粒是否可以缓解中毒后的透析限制？
Justin Koh,Matthew Quance,Martyn Harvey et al.
Justin Koh et al.
Background: The reach of dialysis in toxicology is limited by two factors, high toxicant volume of distribution and low dialytic extraction of protein bound toxicants in blood. Therapeutic actions for lipid emulsion as an...
Development and validation of a machine learning model for early prediction of intensive care unit acquired weakness [0.03%]
重症监护病房获得性肌无力早期预测的机器学习模型的开发和验证
Felipe Kenji Nakano,Nathalie Van Aerde,Grégoire Coppens et al.
Felipe Kenji Nakano et al.
Background: Early identification of potential high cost and high need patients on the ICU may assist in the development of targeted protocols, which allows proper resource utilization and initialization of preventive care...
Correspondence about the article "Left ventricular systolic longitudinal strain in mechanically ventilated patients in the intensive care unit: assessment of global and chamber reproducibility"-author's reply [0.03%]
关于《体外循环下心脏术后患者早期左心室收缩功能的对比研究》一文的来信-作者回复
Matías Pécora,Piero Pastorini,Roberto Farolini et al.
Matías Pécora et al.
Effect of mannitol on diuresis and acid-base equilibrium in critically ill patients [0.03%]
甘露醇对重症患者利尿及酸碱平衡的影响
Davide Chiumello,Clara Aiello,Tommaso Pozzi et al.
Davide Chiumello et al.
Background: Mannitol is the most commonly used osmotic diuretic, but its effect on plasma and urine electrolytes and on acid-base equilibrium have not been well investigated. The aim of this study was to evaluate the shor...
Total liquid ventilation in a porcine model of severe acute respiratory distress syndrome using a new generation of liquid ventilator [0.03%]
一种新型液体通气机在重度急性呼吸窘迫综合征猪模型中进行完全液体通气的研究
Naoto Watanabe,Antoine Bois,Fanny Lidouren et al.
Naoto Watanabe et al.
Background: Total liquid ventilation (TLV) has been experimentally proposed as an alternative treatment for the management of Acute Respiratory Distress Syndrome (ARDS). Recent technological advances have led to the evalu...
Gas as medicine: the case for hydrogen gas as a therapeutic agent for critical illness [0.03%]
气体作为药物：氢气作为危重疾病治疗剂的可行性研究
Lakhmir S Chawla
Lakhmir S Chawla
Molecular hydrogen gas (HG), administered through inhalation or as hydrogen-rich fluids (HRF), has demonstrated antioxidant, anti-inflammatory, antiapoptotic, cytoprotective, and beneficial mitochondrial effects in critical illness. Preclin...
Regional venous-to-arterial carbon dioxide pressure and content differences during endotoxemic shock: influence of hydrogen ion accumulation vs. Haldane effect [0.03%]
内毒素性休克时的区域静脉至动脉二氧化碳分压和含量差：氢离子蓄积与汉德安效应的影响
Gustavo A Ospina-Tascón,Daniel De Backer,José L Aldana et al.
Gustavo A Ospina-Tascón et al.
Background: The relationship between carbon dioxide pressures (PCO2) and contents (CCO2) is linked to the Haldane effect. Nevertheless, under shock conditions, hydrogen ion accumulation might strongly influence the discre...
Uncovering molecular markers of the microvascular endothelial response in sepsis-associated acute kidney injury: a translational study in mice and humans [0.03%]
用于急性肾损伤的微观血管内皮反应的分子标志物的发现：小鼠和人类中的转化研究
T J van der Aart,G Molema,R M Jongman et al.
T J van der Aart et al.
Introduction: Endothelial cells play a central role in the pathophysiology of sepsis-associated acute kidney injury (SA-AKI), yet we have limited understanding of the markers of microvascular-specific response. We therefo...