Renin-angiotensin system activation and oxidative stress in hospitalized COVID-19 patients: a single-centre prospective observational study [0.03%]
住院COVID-19患者肾素血管紧张素系统激活与氧化应激的一项单中心前瞻性观察研究
Davide Eleuteri,Filippo Del Tedesco,Federico Silvia et al.
Davide Eleuteri et al.
Background: The renin-angiotensin system (RAS) plays a critical role in vascular homeostasis and inflammation, and its dysregulation has been implicated in the pathophysiology of COVID-19. We investigated the dynamics of ...
Immune dysregulation through longitudinal lymphocyte trajectories and their clinical determinants in hospitalized COVID-19 patients [0.03%]
住院COVID-19患者的纵向淋巴细胞轨迹及其临床决定因素导致免疫失调
José Pedro Cidade,Fabio Silvio Taccone,Luis Felipe Reyes et al.
José Pedro Cidade et al.
Objective: Immune dysregulation plays a pivotal role in the pathophysiology of sepsis and COVID-19, with lymphopenia emerging as a consistent marker of severity and poor prognosis. However, most existing studies have asse...
Albumin kinetics, intravascular fluid volume, and respiratory function in pigs ventilated at different levels of mechanical power following crystalloid vs. albumin infusion [0.03%]
晶体液与白蛋白输注对不同机械通气功率所致呼吸功能障碍的血清白蛋白动力学及血管内容量的影响
Simone Gattarello,Gaetano Gazzé,Emanuele Rollo et al.
Simone Gattarello et al.
Background: The rationale of albumin use lies in its potential to increase oncotic pressure and optimize tissue perfusion. Randomized trials have not demonstrated a survival benefit, and the effects of albumin on volemia ...
The therapeutic potential of high-dose inhaled nitric oxide for antimicrobial effects: a narrative review and future directions [0.03%]
高剂量吸入一氧化氮的抗菌潜力：综述与未来方向
Lorenzo Berra,Nikolay Kamenshchikov,Asher Tal et al.
Lorenzo Berra et al.
Inhaled nitric oxide (iNO), long used as a selective pulmonary vasodilator, has demonstrated potential antimicrobial and antiviral properties when administered at high concentrations (> 20 parts per million, ppm). While definitive evidence ...
Pre-existing systemic inflammation impairs bacterial clearance in the spleen [0.03%]
脾脏清除细菌的能力受全身炎症的影响
Katja Hanslin,Paul Skorup,Frida Wilske et al.
Katja Hanslin et al.
Background: Sepsis-induced immunosuppression impairs bacterial clearance and increases mortality. Liver and spleen macrophages are an essential part of the mononuclear phagocyte system and crucial for bacterial eliminatio...
Microbial lung-to-blood translocation associates with systemic inflammation in severe pneumonia: evidence from paired plasma and lower respiratory tract metagenomics [0.03%]
重症肺炎中肺源微生物血流播散与全身炎症关联的证据：基于血浆和下呼吸道宏基因组学的配对研究
Haopu Yang,Matthew K Hensley,Vi D-B Nguyen et al.
Haopu Yang et al.
Background: Biological heterogeneity in host inflammatory responses to severe pneumonia predicts clinical outcomes and may influence the effectiveness of immunomodulatory therapy. The upstream drivers of this heterogeneit...
Impaired systemic antibody response against gut microbiota pathobionts in critical illness and susceptibility to nosocomial infections [0.03%]
重症患者对肠道微生物病原体的系统性抗体反应受损及其对医院感染的易感性
Nicole A Cho,Jared Schlechte,Ian-Ling Yu et al.
Nicole A Cho et al.
Background: Critically ill patients in intensive care units (ICUs) experience high rates of hospital-acquired (nosocomial) infections, commonly caused by translocation and dissemination of pathogenic microorganisms that c...
Georg Franz Lehner,Timo Mayerhöfer,Fabian Perschinka et al.
Georg Franz Lehner et al.
Perioperative micro-arterial function and extravasation in cytoreductive ovarian cancer surgery: an observational study [0.03%]
卵巢癌细胞减灭术中的围手术期微动脉功能和外渗的一项观察性研究
Aarne Feldheiser,Jana-Jennifer Dathe,Sandra Heinig et al.
Aarne Feldheiser et al.
Background: Patients undergoing extended multivisceral, non-cardiac surgery require a high demand for intravenous fluid administration, leading to substantial positive fluid balances. This study aimed to perioperatively c...
Machine learning-driven prediction model for successful weaning of patients from mechanical ventilation in ICU [0.03%]
基于机器学习的预测ICU患者成功脱离机械通气模型
Changcui Qiu,Lulu Tang,Yugang Zhuang et al.
Changcui Qiu et al.
Background: Mechanical ventilation is a critical life support technology in the intensive care unit. However, the weaning process remains complex, making the optimal timing for liberation from ventilation challenging to a...