Herpes Simplex Vaccines: Prospects of Live-attenuated HSV Vaccines to Combat Genital and Ocular infections [0.03%]
单纯疱疹病毒疫苗：用减毒活HSV疫苗防治生殖器和眼部感染的前景
Brent Stanfield,Konstantin Gus Kousoulas
Brent Stanfield
Herpes simplex virus type-1 (HSV-1) and its closely related type-2 (HSV-2) viruses cause important clinical manifestations in humans including acute ocular disease and genital infections. These viruses establish latency in the trigeminal ga...
Rosalynn Louise Ord,Cheryl A Lobo
Rosalynn Louise Ord
Human babesiosis is a zoonotic disease caused by protozoan parasites of the Babesia genus, primarily in the Northeastern and Midwest United States due to B. microti, and Western Europe due to B. divergens. Parasites are transmitted by the b...
Bethany A Rhein,Wendy J Maury
Bethany A Rhein
Filoviruses cause severe hemorrhagic fever in humans. The archetypal virus of this group, Ebola virus, is responsible for the current filovirus epidemic in West Africa. Filoviruses infect most mammalian cells, resulting in broad species tro...
David S Perlin,Erika Shor,Yanan Zhao
David S Perlin
Invasive fungal infections remain a major source of global morbidity and mortality, especially among patients with underlying immune suppression. Successful patient management requires antifungal therapy. Yet, treatment choices are restrict...
Leah Imlay,Audrey R Odom
Leah Imlay
Apicomplexan parasites include some of the most prevalent and deadly human pathogens. Novel antiparasitic drugs are urgently needed. Synthesis and metabolism of isoprenoids may present multiple targets for therapeutic intervention. The apic...
Robert M Greenberg
Robert M Greenberg
Infections with parasitic helminths such as schistosomes and soil-transmitted nematodes are hugely prevalent and responsible for a major portion of the global health and economic burdens associated with neglected tropical diseases. In addit...