Varicella-Zoster Virus Glycoproteins: Entry, Replication, and Pathogenesis [0.03%]
水痘-带状疱疹病毒糖蛋白：进入、复制和致病性
Stefan L Oliver,Edward Yang,Ann M Arvin
Stefan L Oliver
Varicella-zoster virus (VZV), an alphaherpesvirus that causes chicken pox (varicella) and shingles (herpes zoster), is a medically important pathogen that causes considerable morbidity and, on occasion, mortality in immunocompromised patien...
Reexamining Chronic Toxoplasma gondii Infection: Surprising Activity for a "Dormant" Parasite [0.03%]
重新审视慢性弓形虫感染：“休眠”寄生虫的意外活动
Anthony P Sinai,Elizabeth A Watts,Animesh Dhara et al.
Anthony P Sinai et al.
Purpose of review: Despite over a third of the world's population being chronically infected with Toxoplasma gondii, little is known about this largely asymptomatic phase of infection. This stage is mediated in vivo by br...
Hector C Aguilar,Bryce A Henderson,J Lizbeth Zamora et al.
Hector C Aguilar et al.
The family Paramyxoviridae includes many viruses that significantly affect human and animal health. An essential step in the paramyxovirus life cycle is viral entry into host cells, mediated by virus-cell membrane fusion. Upon viral entry, ...
Filamentous Influenza Viruses [0.03%]
丝状流感病毒
Matthew D Badham,Jeremy S Rossman
Matthew D Badham
Influenza A virus is a pathogen of global medical importance causing significant health and socio-economic costs every year. Influenza virus is an unusual pathogen in that it is pleomorphic, capable of forming virions ranging in shape from ...
Nucleic acid sensing and innate immunity: signaling pathways controlling viral pathogenesis and autoimmunity [0.03%]
核酸感受与固有免疫：调控病毒致病性和自身免疫的信号通路
Laura R H Ahlers,Alan G Goodman
Laura R H Ahlers
Innate immunity refers to the body's initial response to curb infection upon exposure to invading organisms. While the detection of pathogen-associated molecules is an ancient form of host defense, if dysfunctional, autoimmune disease may r...
Use of Fungal Diagnostics and Therapy in Pediatric Cancer Patients in Resource-Limited Settings [0.03%]
资源匮乏条件下儿童肿瘤患者真菌病的诊断与治疗
Sheena Mukkada,Jeannette Kirby,Nopporn Apiwattanakul et al.
Sheena Mukkada et al.
Fungal diseases are an important cause of mortality in immunocompromised hosts, and their incidence in pediatric cancer patients in low- to middle-income countries is underestimated. In this review, we present relevant, up-to-date informati...
Stacey A Maskarinec,Melissa D Johnson,John R Perfect
Stacey A Maskarinec
The development of severe fungal infections has long been associated with traditional risk factors such as profound immunosuppression, yet it remains challenging to understand why under similar conditions only some patients will develop the...
Christopher Nosala,Scott C Dawson
Christopher Nosala
Giardia lamblia is a flagellated parasite of the gut and causes significant morbidity worldwide. Novel druggable targets are sorely needed due to Giardia's prevalence and the growing threat of antibiotic resistance. Giardia's conserved and ...
HIV-Associated Cryptococcal Meningitis: Bridging the Gap Between Developed and Resource-Limited Settings [0.03%]
艾滋病相关隐球菌性脑膜炎：连接发达国家和发展中国家的差距
Mark W Tenforde,Rae Wake,Tshepo Leeme et al.
Mark W Tenforde et al.
Cryptococcal meningitis is a major cause of HIV-associated morbidity and mortality worldwide. Most cases occur in low-income countries, where over half of patients die within 10 weeks of diagnosis compared to as few as 10 % of patients from...
Chlamydial Antibiotic Resistance and Treatment Failure in Veterinary and Human Medicine [0.03%]
兽医和人类医学中的沙眼衣原体抗生素耐药性和治疗失败
Nicole Borel,Cory Leonard,Jessica Slade et al.
Nicole Borel et al.
The Chlamydiaceae are widespread pathogens of both humans and animals. Chlamydia trachomatis infection causes blinding trachoma and reproductive complications in humans. Chlamydia pneumoniae causes human respiratory tract infections and aty...