First Impressions-the Potential of Altering Initial Host-Virus Interactions for Rational Design of Herpesvirus Vaccine Vectors [0.03%]
第一印象——改造初始宿主病毒互作的潜力以合理设计疱疹病毒疫苗载体的前景
Paul J F Rider,Farhana Musarrat,Rafiq Nabil et al.
Paul J F Rider et al.
Purpose: The earliest host-virus interactions occur during virus attachment and entry into cells. These initial steps in the virus lifecycle influence the outcome of infection beyond delivery of the viral genome into the ...
Understanding mechanisms underlying the pathology of immune reconstitution inflammatory syndrome (IRIS) by using animal models [0.03%]
利用动物模型了解免疫重建炎症综合征（IRIS）病理机制的原理
Nupur Aggarwal,William Barclay,Mari L Shinohara
Nupur Aggarwal
Purpose of review: Despite the increasing number of clinical reports on immune reconstitution inflammatory syndrome (IRIS), mechanistic understanding of IRIS is still largely limited. The main focus of this review is to s...
Carolyn M Clark,Antonieta Guerrero-Plata
Carolyn M Clark
Purpose of review: Respiratory syncytial virus (RSV) is a global human pathogen responsible for lower respiratory tract infections (LRTI). While RSV infection is innocuous in healthy adults, it is the leading cause of inf...
Pathogenesis of Chronic Chagas Disease: Macrophages, Mitochondria, and Oxidative Stress [0.03%]
慢性查加斯病的发病机制：巨噬细胞、线粒体和氧化应激
Marcos Lopez,Herbert B Tanowitz,Nisha J Garg
Marcos Lopez
Purpose of review: Trypanosoma cruzi is the causative agent of Chagas disease. Decades after initial infection, ~30% of individuals can develop chronic chagasic cardiomyopathy. There are several proposed mechanisms for pa...
Rotavirus vaccines: why continued investment in research is necessary [0.03%]
轮状病毒疫苗：为什么继续在研究方面进行投资是必要的
Michelle M Arnold
Michelle M Arnold
Purpose of review: Rotavirus vaccines were first introduced more than a decade ago and have had a tremendous impact on reducing the number of hospitalizations and deaths due to rotavirus-associated diarrhea. This review w...
Examining the potential for South American arboviruses to spread beyond the New World [0.03%]
南美洲虫媒病毒向新大陆以外地区传播的潜在可能性不容小觑
Víctor Hugo Peña-García,Michael K McCracken,Rebecca C Christofferson
Víctor Hugo Peña-García
Zika and chikungunya viruses emerged as public health emergencies in the Western Hemisphere where previously they had not been reported on a large scale. Millions were infected as the viruses met with virtually no herd immunity upon emergen...
Donna Collins-McMillen,Felicia D Goodrum
Donna Collins-McMillen
Purpose of review: Herpesvirus latency has been viewed as a binary state where replication is either on or off. During latency, gene expression is thought to be restricted to non-coding RNAs or very few proteins so that t...
Jane A O&#x;Halloran,William G Powderly,Andrej Spec
Jane A O&#x;Halloran
Purpose of the review: Cryptococcal disease is most often thought of in the context of HIV infection. Much of our knowledge of the disease originates from its management in the HIV-positive population over the last 30 yea...
JC Polyomavirus Attachment and Entry: Potential Sites for PML Therapeutics [0.03%]
JC多瘤病毒的吸附和进入：PML治疗的潜在位点
Colleen L Mayberry,Christian D S Nelson,Melissa S Maginnis
Colleen L Mayberry
Purpose of review: JC polyomavirus (JCPyV) is a significant human pathogen that causes an asymptomatic infection in the kidney in the majority of the population. In immunosuppressed individuals, the virus can become react...
Signaling in Parasitic Nematodes: Physicochemical Communication Between Host and Parasite and Endogenous Molecular Transduction Pathways Governing Worm Development and Survival [0.03%]
寄生线虫的信号传导：宿主与寄生物理化学通讯及控制线虫发育和存活的内源性分子转导途径
James B Lok
James B Lok
Signaling or communication between host and parasite may occur over relatively long ranges to enable host finding and acquisition by infective parasitic nematode larvae. Innate behaviors in infective larvae transmitted from the soil that en...