Conserved and Divergent Features of pH Sensing in Major Fungal Pathogens [0.03%]
主要真菌病原体中pH感应的保守性和差异性特征
Shadab Farhadi Cheshmeh Morvari,Bethany L McCann,Elaine M Bignell
Shadab Farhadi Cheshmeh Morvari
Purpose of review: For human fungal pathogens, sensory perception of extracellular pH is essential for colonisation of mammalian tissues and immune evasion. The molecular complexes that perceive and transmit the fungal pH...
Jillian Freese,Sinem Beyhan
Jillian Freese
Purpose of review: Fungi represent a central yet often overlooked domain of clinically relevant pathogens that have become increasingly important in human disease. With unique adaptive lifestyles that vary widely across s...
The Metabolism of Susceptibility: Clearing the FoG Between Tolerance and Resistance in Candida albicans [0.03%]
耐受与抵抗力之间的模糊性：白色念珠菌中易感性的代谢清除
Marina Druseikis,Austin Mottola,Judith Berman
Marina Druseikis
Purpose of review: Failure of antifungal treatment is alarmingly common in patients infected with Candida albicans isolates that test as susceptible in vitro. This means that clinical susceptibility tests have limited pre...
The Role of Host and Fungal Factors in the Commensal-to-Pathogen Transition of Candida albicans [0.03%]
白色念珠菌共生到致病转变中的宿主和真菌因素的作用
Ilse D Jacobsen
Ilse D Jacobsen
Purpose of review: The fungus Candida albicans has evolved to live in close association with warm-blooded hosts and is found frequently on mucosal surfaces of healthy humans. As an opportunistic pathogen, C. albicans can ...
Is There a Relationship Between Mating and Pathogenesis in Two Human Fungal Pathogens, Candida albicans and Candida glabrata? [0.03%]
两种人类病原性真菌白色念珠菌和光滑念珠菌的交配与致病性的关系研究
Tina Bedekovic,Jane Usher
Tina Bedekovic
Purpose of review: Human fungal pathogens are rapidly increasing in incidence and readily able to evade the host immune responses. Our ability to study the genetic behind this has been limited due to the apparent lack of ...
Joydeep Nag,Janvi Patel,Shashank Tripathi
Joydeep Nag
Purpose of review: Virus infections skew the host autophagic response to meet their replication and transmission demands by tapping into the critical host regulatory mechanisms that control the autophagic flux. This revie...
MinION Whole-Genome Sequencing in Resource-Limited Settings: Challenges and Opportunities [0.03%]
资源有限环境下MinION全基因组测序：挑战与机遇
Fredrickson B Wasswa,Kennedy Kassaza,Kirsten Nielsen et al.
Fredrickson B Wasswa et al.
Purpose of review: The introduction of MinION whole-genome sequencing technology greatly increased and simplified complete genome sequencing in various fields of science across the globe. Sequences have been generated fro...
When to Initiate Antifungal Treatment in COVID-19 Patients with Secondary Fungal Co-infection [0.03%]
COVID-19合并真菌共感染患者何时开始抗真菌治疗合适
Harnoor Singh Pruthi
Harnoor Singh Pruthi
Purpose of review: Severe-acute respiratory coronavirus 2 (SARS-CoV-2) has been driving the health care delivery system for over 2 years. With time, many issues related to co-infections in COVID-19 patients are constantly...
Emerging Fungal Infections: from the Fields to the Clinic, Resistant Aspergillus fumigatus and Dermatophyte Species: a One Health Perspective on an Urgent Public Health Problem [0.03%]
从农田到诊所的新兴真菌感染：烟曲霉和表皮癣菌病原种：紧急公共卫生问题“同一健康”的观点
Antonia Langfeldt,Jeremy A W Gold,Tom Chiller
Antonia Langfeldt
Purpose of review: For this review, we use a One Health approach to examine two globally emerging public health threats related to antifungal drug resistance: triazole-resistant Aspergillus fumigatus infections, which can...
Comparison of Survival and Clinical Profile of Adults with COVID-19 Hospitalized in Two Clinics in Medellín, Colombia [0.03%]
哥伦比亚梅德ellín两家诊所收治的成人COVID-19患者的生存和临床特征比较
Juan Carlos Cataño-Correa,Jaiberth Antonio Cardona-Arias,Jessica Paola Porras-Mancilla et al.
Juan Carlos Cataño-Correa et al.
Purpose of review: This study compares the survival and clinical profile of hospitalized adults with COVID-19 in two clinics in the city of Medellín, Colombia, with a prospective study with 198 patients in clinic A and 2...