Hannes Hagström
Hannes Hagström
Purpose of review: High consumption of alcohol can lead to cirrhosis. The risk of a low to moderate consumption of alcohol in the setting of a concurrent liver disease is less clear. The aim of this review is to sum the e...
Are Dominant Strictures in Primary Sclerosing Cholangitis a Risk Factor for Cholangiocarcinoma? [0.03%]
原发性硬化性胆管炎主导狭窄会增加胆管癌的风险吗？
Roger W Chapman,Kate D Williamson
Roger W Chapman
Purpose of review: Cholangiocarcinoma is a devastating, unpredictable complication of large duct primary sclerosing cholangitis (PSC), which occurs in 5-15% of patients. The aim of this review is to discuss whether domina...
Why Doesn't Primary Biliary Cholangitis Respond to Immunosuppressive Medications? [0.03%]
为什么原发性胆汁性胆管炎对免疫抑制药物无反应？
Antonio Molinaro,Hanns-Ulrich Marschall
Antonio Molinaro
Purpose of review: The purpose of this review is to discuss reasons why immunosuppressive therapy so far failed in Primary Biliry Cholangitis. Recent find...
Treatment of HCV in Renal Disease: Subtle Management Considerations in the Era of Direct-acting Antivirals [0.03%]
直接抗病毒药物时代背景下肾病患者HCV治疗的注意事项
Yuval A Patel,Andrew J Muir
Yuval A Patel
Chronic hepatitis C virus (HCV) infection is burdensome in patients with chronic kidney disease and contributes to substantial liver-related and all-cause morbidity and mortality. HCV infection itself may cause kidney dysfunction, as exempl...
Tailored algorithms for hepatocellular carcinoma surveillance: Is one-size-fits-all strategy outdated? [0.03%]
肝细胞癌筛查的个性化算法：千篇一律的策略是否过时？
Nicolas Goossens,C Billie Bian,Yujin Hoshida
Nicolas Goossens
Purpose of review: Current clinical practice guidelines recommend regular hepatocellular carcinoma (HCC) surveillance with biannual ultrasound with or without serum alpha-fetoprotein uniformly applied to all patients with...
Daniel Bushyhead,David Goldberg
Daniel Bushyhead
Purpose of review: The purpose of this article is to review recent literature regarding the use of Hepatitis C virus (HCV) positive donor livers in liver transplantation. Given the prevalence of HCV-positive patients on t...
Edward A Pham,Ryan B Perumpail,Benjamin J Fram et al.
Edward A Pham et al.
Although currently available therapies for chronic hepatitis B virus infection can suppress viremia and provide long-term benefits for patients, they do not lead to a functional cure for most patients. Advances in our understanding of the v...
Noninvasive Markers of Fibrosis and Inflammation in Nonalcoholic Fatty Liver Disease [0.03%]
非酒精性脂肪肝病纤维化和炎症的无创标志物
Saumya Jayakumar,Stephen A Harrison,Rohit Loomba
Saumya Jayakumar
The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. Nonalcoholic steatohepatitis (NASH) and fibrosis are associated with elevated morbidity and mortality, and a means of differentiating these diseases from si...
Julia Wattacheril,Arun J Sanyal
Julia Wattacheril
Nonalcoholic fatty liver disease (NAFLD) is commonly diagnosed in obese or overweight individuals. However, lean individuals with NAFLD are not rare but represent one significant end of the phenotypic spectrum of NAFLD. Although initial obs...
Lisa B VanWagner,Mary E Rinella
Lisa B VanWagner
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide with an increased prevalence of metabolic, macro- and microvascular complications. The primary causes of mortality in NAFLD are cardiovascu...