Pharmacotherapies for Portal Hypertension: Current Status and Expanding Indications [0.03%]
门脉高压症的药物治疗：现状与扩大适应证
Mohamed A Elfeki,Ashwani K Singal,Patrick S Kamath
Mohamed A Elfeki
Purpose: Non-selective beta blockers remain pharmacotherapy of choice for prevention of first episode of variceal bleeding (primary prevention) and for prevention of its recurrence after initial hemostasis (secondary prop...
Matthew J McConnell,Yasuko Iwakiri
Matthew J McConnell
Purpose of review: This review article will examine portal hypertension in alcoholic hepatitis (AH) from both a basic mechanistic and a clinical perspective. ...
Eric Felli,Yelidousi Nulan,Sonia Selicean et al.
Eric Felli et al.
Purpose of review: Portal hypertension is responsible of the main complications of cirrhosis, which carries a high mortality. Recent treatments have improved prognosis, but this is still far from ideal. This paper reviews...
Omar T Ahmed,Alina M Allen
Omar T Ahmed
Purpose of review: Malignancy is the second most common cause of death in individuals with nonalcoholic fatty liver disease (NAFLD). Understanding unique characteristics of malignancy risk beyond hepatocellular carcinoma ...
Gaëtan Ligat,Kaku Goto,Eloi Verrier et al.
Gaëtan Ligat et al.
Purpose of review: Chronic hepatitis B (CHB), caused by hepatitis B virus (HBV), is a major cause of advanced liver disease and hepatocellular carcinoma (HCC) worldwide. HBV replication is characterized by the synthesis o...
Ju Dong Yang,Lewis R Roberts
Ju Dong Yang
Purpose of review: To review the recent consensus on the nomenclature, clinical features, diagnosis, and treatment of combined hepatocellular carcinoma-cholangiocarcinoma (cHCC-CCA). ...
Guillermo A Ortiz,Guadalupe Garcia-Tsao
Guillermo A Ortiz
Purpose of review: To provide an overview of recent pharmacological treatments for portal hypertension evaluated in early clinical trials, with particular emphasis on the pathophysiological basis of their use. ...
Kathryn E Driggers,Brett W Sadowski,Eva Shagla et al.
Kathryn E Driggers et al.
Background and purpose of review: The COVID-19 pandemic has resulted in over 800,000 deaths worldwide and resulted in fundamental changes in practice in nearly every aspect of medicine. The majority of symptomatic patient...
Advance Care Planning and Goals of Care Discussions in Advanced Liver Disease [0.03%]
晚期肝病的预前护理规划和照护目标讨论
Nneka N Ufere
Nneka N Ufere
Purpose of review: Advance care planning (ACP) has been shown to improve multiple outcomes in patients with serious illnesses; however, patients with advanced liver disease, or cirrhosis, rarely receive timely ACP. The pu...
Emmanuel Thomas,Stephanie Delabat,David M Andrews
Emmanuel Thomas
Purpose of review: Given the rapid development of diagnostic approaches to test for and diagnose infection with SARS-CoV-2, many options are available to assess infection. Multiple established diagnostic companies are now...