Determination of SK3497 in rat plasma and its application in a pharmacokinetic study of SK3497 [0.03%]
SK3497在大鼠血浆中的测定及其在SK3497药代动力学研究中的应用
T K Kim,Y S Ji,M H Park et al.
T K Kim et al.
In this study, a sensitive and reliable method for the quantitation of SK3497 in rat plasma was developed and validated using high performance liquid chromatography. The plasma samples were prepared by deproteinization, and sildenafil was u...
Genistein prevents cadmium-induced neurotoxic effects through its antioxidant mechanisms [0.03%]
染料木素通过其抗氧化机制预防镉引起的神经毒性作用
D-k Gong,B-h Liu,X-h Tan
D-k Gong
Introduction: Cadmium-induced neurotoxic effects are mediated through adverse oxidative stress and calcium signaling. Genistein, a phytoestrogen is a potent antioxidant and exhibits property to cross blood-brain barrier. ...
Endothelin receptor inhibition with bosentan delays onset of liver injury in streptozotocin-induced diabetic condition [0.03%]
内皮素受体拮抗剂波生坦延迟链脲佐菌素诱导的糖尿病小鼠肝损伤的发生发展过程
E Demirci,I Ferah,C Gundogdu et al.
E Demirci et al.
Background: This study was designed to investigate the protective effects of bosentan an orally active non-peptide mixed ETA/ETB receptor antagonist, on liver injury in streptozotocin-induced diabetic rats. ...
Diclofenac-Choline Antioxidant Activity Investigated by means of Luminol Amplified Chemiluminescence of Human Neutrophil Bursts and Electron Paramagnetic Resonance Spectroscopy [0.03%]
用化学发光和电子顺磁共振光谱研究双氯芬酸-氯化胆碱的抗氧化活性
P C Braga,N Lattuada,V Greco et al.
P C Braga et al.
A new diclofenac salt called diclofenac-choline (DC) has recently been proposed for the symptomatic treatment of oropharyngeal inflammatory processes and pain because its greater water solubility allows the use of high concentrations, which...
Synthesis and biological evaluation of some new amide moiety bearing quinoxaline derivatives as antimicrobial agents [0.03%]
一类含喹唑啉结构衍生物的合成及其抗微生物活性研究
U Abu Mohsen,L Yurttaş,U Acar et al.
U Abu Mohsen et al.
In this study, we aimed to synthesize some new quinoxaline derivatives bearing amide moiety and to evaluate their antimicrobial activity. A set of 16 novel compounds of N-[2,3-bis(4-methoxy/methylphenyl)quinoxalin-6-yl]-substituted benzamid...
Antidepressant and anxiolytic effects of the methanol root extract of Capparis thonningii: involvement of monoaminergic, cholinergic and GABAergic systems [0.03%]
Capparis thonningii 根的甲醇提取物抗抑郁和抗焦虑作用：单胺能、胆碱能和GABA能系统的参与
I O Ishola,S O Olayemi,O K Yemitan et al.
I O Ishola et al.
Background: Capparis thonningii Schum. (Capparaceae) is used in traditional African Medicine for the treatment of mood disorders. Objective: ...
HLA-B*1502 increases the risk of phenytoin or lamotrigine induced Stevens-Johnson Syndrome/toxic epidermal necrolysis: evidence from a meta-analysis of nine case-control studies [0.03%]
HLA-B*1502增加苯妥英或拉莫三嗪所致Stevens-Johnson综合征/中毒性表皮坏死松解症的风险：九个病例对照研究的Meta分析证据
X Li,K Yu,S Mei et al.
X Li et al.
Background and study aims: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are fatal adverse cutaneous drug reactions which may be induced by phenytoin (PHT) or lamotrigine (LTG). The objective of this...
Meta-Analysis
Drug research. 2015 Feb;65(2):107-11. DOI:10.1055/s-0034-1375684 2015
A prospective research study of anti-glaucoma drugs prescribing, utilization pattern and adverse drug reaction recording in a university hospital [0.03%]
一所大学医院抗青光眼药物处方、使用情况和不良反应记录的前瞻性研究
M Alaei,A K Najmi,H Kausar et al.
M Alaei et al.
Objective: This study was carried out to evaluate the drug prescribing, utilization pattern and adverse drug reactions recording associated with drugs prescribed to glaucoma patients. ...
Synthesis and Pharmacological Evaluation of New Chemical Entities from Ibuprofen as Novel Analgesic Candidates [0.03%]
新型止痛药候选药物的吲哚美辛衍生物的设计合成与药理评价
A Ahmadi,N Naderi,M Daniali et al.
A Ahmadi et al.
Non-steroidal anti-inflammatory drugs (NSAIDs) are the first choice of drugs that are normally used for the treatment of pain and inflammation. Ibuprofen (I) and its analogues as the most widely used NSAIDs have been synthesized in recent y...
Clinical Applications of Saffron (Crocus sativus) and its Constituents: A Review [0.03%]
藏红花（克艾克萨图斯）及其成分的临床应用：综述
M Moshiri,M Vahabzadeh,H Hosseinzadeh
M Moshiri
Commonly known as saffron, Crocus sativus L and its active components have shown several useful pharmacological effects such as anticonvulsant, antidepressant, anti-inflammatory, antitumor, radical scavenger effects, learning and memory imp...