Efficacy of Mitiglinide Combined with Dapagliflozin in Streptozotocin-nicotinamide-induced Type 2 Diabetic Rats and in Zucker Fatty Rats [0.03%]
米格列奈联合达格列净对链脲佐菌素-烟酸诱导的2型糖尿病大鼠及 Zucker 糖尿病脂肪 rat 的疗效研究
K Akahane,T Inoue,A Yokoyama et al.
K Akahane et al.
The efficacy of the combination of the rapid-acting insulin secretagogue mitiglinide and the sodium-glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin was explored in streptozotocin-nicotinamide-induced type 2 diabetic (STZ-NA) rats an...
F Yasemin Özatik,B Kaygısız,K Erol et al.
F Yasemin Özatik et al.
We aimed to investigate the effects and mechanisms of action of p-nonylphenol(p-NP) on uterine contractility in rats. The uterine tissues of female Sprague Dawley rats in diestrus were bathed in isolated organ bath. The effects of vehicle a...
Relationship between Tetracyclines' Structure and Minimal Inhibitory Concentration of Streptococcus spp [0.03%]
四环素类结构与链球菌最小抑菌浓度关系研究
M Marczak,T Grabowski,M Feder
M Marczak
During the past years, a growing number of bacterial strains have become resistant to tetracyclines. The problem of increasing resistance and lack of susceptibility to tetracyclines applies to strains isolated from both: animals and humans....
Synthesis and characterization of some substituted 3, 4-dihydronaphthalene derivatives through different enaminones as potent cytotoxic agents [0.03%]
通过不同的烯胺酮合成并表征一些具有潜在细胞毒性的3,4-二氢萘衍生物
M E Haiba,E S Al-Abdullah,M M Edrees et al.
M E Haiba et al.
A new series of novel substituted 3,4-dihydronaphthalene incorporated to benzo[h]quinoline, benzo[g]indazole, thiazolidin-4-one, pyrazolo[3,4-d]thiazol and thiazolo[4,5-b]pyridine ring systems were synthesized and evaluated for their cytoto...
Synthesis and Antimicrobial Activity of 5-(morpholinosulfonyl)isatin Derivatives Incorporating a Thiazole Moiety [0.03%]
含噻唑类化合物的5-（吗啉磺酰基）吲哚衍生物的合成及抗菌活性研究
A A Farag
A A Farag
This article describes the synthesis of novel 5-(morpholinosulfonyl)isatin derivatives having biologically active thiazole moiety were synthesized via 2 synthetic routes. The first route involved interaction of 5-(morpholino-sulfonyl) isati...
Impact of Herbal Medicines like Nigella sativa, Trigonella foenum-graecum, and Ferula asafoetida, on Cytochrome P450 2C11 Gene Expression in Rat Liver [0.03%]
植物药如Nigella sativa、Trigonella foenum-graecum和Ferula asafoetida对大鼠肝脏CYP2C11基因表达的影响
H M Korashy,F I Al-Jenoobi,M Raish et al.
H M Korashy et al.
Aim: Combined use of herbs and drugs may result in clinically important herb-drug interactions. The majorities of these interactions are thought to be metabolism-based and involve induction or inhibition of cytochrome P45...
Quantitative determination of fluconazole by ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) in human plasma and its application to a pharmacokinetic study [0.03%]
人血浆中氟康唑的定量检测及其在药代动力学研究中的应用
J-J Song,W Li,Z Wang et al.
J-J Song et al.
In this study, a simple, rapid and sensitive ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method is described for determination of fluconazole (FLA) in human plasma samples using phenacetin as the internal s...
Clinical Trial
Drug research. 2015 Jan;65(1):52-6. DOI:10.1055/s-0034-1384610 2015
Gabapentin Enhances Neurogenesis in E14 Rat Embryonic Neocortex Stem Cells [0.03%]
加巴喷丁增强E14大鼠胚胎新皮质干细胞的神经发生作用
B Paknejad,A Kebriaeezadeh,M H Ghahremani et al.
B Paknejad et al.
Many anticonvulsant drugs have been studied for their non conventional therapeutic effects on neurodegerative diseases but merely a few demonstrated potential neurogenic characteristic. Gabapentin as a well-known mood stabilizer was studied...
Ethanol extract and isolated constituents from artemisia dracunculus inhibit esophageal squamous cell carcinoma and induce apoptotic cell death [0.03%]
Artemisia Dracunculus 的乙醇提取物和分离成分可抑制食管鳞状细胞癌并诱导细胞凋亡死亡
L Hong,S-h Ying
L Hong
The objective of the present study was to examine the antitumor efficacy of the ethanol extract from Artemisia dracunculus as well as the compounds isolated from it on cultured EC‑109 esophageal squamous cell carcinoma (ESCC) cells. Apopto...
Lipid peroxidation and altered anti-oxidant status in breast adenocarcinoma patients [0.03%]
乳腺腺癌患者的脂质过氧化和抗氧化状态改变
C Wang,J Yu,H Wang et al.
C Wang et al.
Introduction: Breast cancer is the one of most common cancer in worldwide which accounts for high mortality rate. Accumulating evidences emphasizes increased oxidative stress plays a major role in the pathogenesis of soli...