Norbert Suttorp,Stefan Endres
Norbert Suttorp
Inter- and Intra-individual Variability in the Pharmacokinetics of Agomelatine Tablets in Chinese Healthy Male Subjects [0.03%]
在中国健康男性受试者中评价阿戈美拉汀片的药代动力学的组间及组内变异
X-l Wang,A-h Du,D Zhang et al.
X-l Wang et al.
Agomelatine is an antidepressant with a unique action mechanism differing from conventional antidepressants. The high inter- and intra-individual variability of agomelatine was previously reported, but no exact data values about the inter- ...
Clinical Trial
Drug research. 2015 Oct;65(10):552-4. DOI:10.1055/s-0034-1394436 2015
Elevated Expression of Nrf-2 and ABCG2 Involved in Multi-drug Resistance of Lung Cancer SP Cells [0.03%]
Nrf-2和ABCG2的高表达与肺癌SP细胞多药耐药相关性研究
B Yang,Y-F Ma,Y Liu
B Yang
Background: Over expression of ATP-binding cassette (ABC) transporter protein (ABCG2) in side population cells plays a crucial role in the chemotherapeutic drug efflux. Constitutive expression of redox sensing transcritpt...
Evaluation of Protein Ubiquitylation in Heart Tissue of Rats Exposed to Diazinon (an Organophosphate Insecticide) and Crocin (an Active Saffron Ingredient): Role of HIF-1α [0.03%]
评估有机磷农药敌百虫和藏红花活性成分藏红素对大鼠心脏组织蛋白质泛素化的影响：HIF-1α的作用
B M Razavi,H Hosseinzadeh,M Imenshahidi et al.
B M Razavi et al.
Introduction: Organophosphate compounds, such as diazinon (DZN), are widely used in agriculture and can lead to formation of reactive oxygen species (ROS) in cardiovascular system. ROS are highly toxic since they can caus...
Comparative Study
Drug research. 2015 Nov;65(11):561-6. DOI:10.1055/s-0034-1384533 2015
DPP-4 Inhibitor Teneligliptin Improves Insulin Resistance and Serum Lipid Profile in Japanese Patients with Type 2 Diabetes [0.03%]
二肽基肽酶-4抑制剂替格列汀改善日本2型糖尿病患者的胰岛素抵抗和血脂谱
M Kusunoki,D Sato,T Nakamura et al.
M Kusunoki et al.
Dipeptidyl peptidase-4 (DPP-4) inhibitors have been reported to improve the glycemic control and blood hemoglobin A1c (HbA1c) concentrations. However, there are few reports as yet suggesting that DPP-4 inhibitors may also improve insulin re...
Clinical Trial
Drug research. 2015 Oct;65(10):532-4. DOI:10.1055/s-0034-1390419 2015
Capillarisin Exhibits Anticancer Effects by Inducing Apoptosis, Cell Cycle Arrest and Mitochondrial Membrane Potential Loss in Osteosarcoma Cancer Cells (HOS) [0.03%]
干姜提取物通过诱导骨肉瘤癌细胞凋亡、阻滞细胞周期和线粒体膜电位降低而产生抗癌作用
N-J Chen,F-Y Hao,H Liu et al.
N-J Chen et al.
The aim of the present study was to assess the anticancer activity of capillarisin against human osteosarcoma (HOS) cancer cells in vitro. Cell viability after capillarisin drug treatment and evaluated by MTT assay. The extent of cell death...
Effect of intravesical botulinum neurotoxin-A injection on detrusor hyperreflexia in spinal cord injured patients [0.03%]
肉毒杆菌素A膀胱内注射对脊髓损伤患者逼尿肌过度反射的影响研究
X-T Ge,Y-F Li,Q Wang et al.
X-T Ge et al.
Purpose: To evaluate the effects of Botulinum Toxin A injection into the detrusor muscle on various voiding parameters in spinal cord injured patients with neurogenic detrusor hyperreflexia Materials and methods: 24 patie...