Involvement of Descending Serotonergic and Noradrenergic Systems and their Spinal Receptor Subtypes in the Antinociceptive Effect of Dipyrone [0.03%]
descending 脊髓多巴胺能系统及其受体亚型在安乃近抗痛觉作用中的机制研究
A Gencer,O Gunduz,A Ulugol
A Gencer
The antinociceptive effect of dipyrone is partly due to its action upon pain-related central nervous system structures. Despite intensive research, the precise mechanisms mediating its analgesic effects remain unclear. Here, we aimed to det...
A Shiva,M Shiran,M Rafati et al.
A Shiva et al.
Objective: Tadalafil is a selective Phosphodiesterase-5 inhibitor that has been reported to have vasodilatory and antiproliferative effects on the pulmonary artery. In this study we evaluated the safety and efficacy of or...
Multicenter Study
Drug research. 2016 Jan;66(1):7-10. DOI:10.1055/s-0034-1395510 2016
Development of QSAR for antimicrobial activity of substituted benzimidazoles [0.03%]
取代苯并咪唑类化合物抗菌活性的QSAR研究发展
N Vashist,S S Sambi,P Kumar et al.
N Vashist et al.
QSAR analysis has been done to correlate antimicrobial activity of substituted benzimidazole derivatives with their physicochemical parameters. Developed QSAR models have been cross validated using leave one out (LOO) method. Statistical pa...
Enhanced Cellular Cytotoxicity and Antibacterial Activity of 18-β-Glycyrrhetinic Acid by Albumin-conjugated PLGA Nanoparticles [0.03%]
白蛋白结合PLGA纳米颗粒增强甘草次酸的细胞毒性和抗菌活性
B Darvishi,S Manoochehri,M Esfandyari-Manesh et al.
B Darvishi et al.
The aim of the present work was to encapsulate 18-β-Glycyrrhetinic acid (GLA) in albumin conjugated poly(lactide-co-glycolide) (PLGA) nanoparticles by a modified nanoprecipitation method. Nanoparticles (NPs) were prepared by different drug...
Evaluation of Wound Healing Activity of Ethanolic Extract of Pongamia pinnata Bark [0.03%]
pongamia pinnata树皮乙醇提取物的伤口愈合作用评估
S K Bhandirge,A S Tripathi,R K Bhandirge et al.
S K Bhandirge et al.
Present study evaluate wound healing activity of ethanolic extract of stem bark of Pongamia pinnata (PP). Evaluation of wound healing activity, 2 wound models were used I. e., incision and excision wounds were perform in this study on Albin...
Codeine Ultra-rapid Metabolizers: Age Appears to be a Key Factor in Adverse Effects of Codeine [0.03%]
-codeine超强代谢者：年龄似乎是-codeine不良反应的关键因素
K Heintze,W Fuchs
K Heintze
Codeine is widely used as an analgesic drug. Taking into account the high consumption of codeine, only few fatal adverse events have been published. A number of reports, where neonates and children showed serious or fatal adverse reactions,...
Relationship between the Peripheral Lymphocyte Response to Mycophenolic Acid in vitro and the Level of ATP in Peripheral CD4+ Lymphocytes before and after Renal Transplantation [0.03%]
他克莫司联合霉酚酸酯肾移植患者外周血CD4+淋巴细胞体外对霉酚酸酯反应与ATP水平的相关性研究
K Sugiyama,M Tsukaguchi,H Sasahara et al.
K Sugiyama et al.
Objective: The lymphocyte immunosuppressant sensitivity test has been used to predict the pharmacodynamics of immunosuppressive drugs for the purpose of preventing acute rejection and infection after renal transplantation...
Clinical Trial
Drug research. 2015 Dec;65(12):629-34. DOI:10.1055/s-0034-1395686 2015
Antitumor Effect of Docetaxel in Osteosarcoma by the Inhibition of Wnt Signal Channel [0.03%]
通过抑制Wnt信号通道杜什 taxel在 osteosarcoma中的抗肿瘤效果
D-Z Wang,J-F Gao,S-F Jing et al.
D-Z Wang et al.
Osteosarcoma (OS) is the most common type of malignant bone tumor in adults and children. Despite the great strides in biology and medicine, the survival rate of patients with metastatic disease remains very poor. This rate has been stagger...
Neurobehavioural and Analgesic Properties of Ethanol Bark Extract of Terminalia ivorensis A Chev. (Combrataceae) in Mice [0.03%]
乙醇提取物神经行为学和镇痛性质终端iapinus阿Chev. （科姆布拉茨）在小鼠中的作用
O A Adeoluwa,A O Aderibigbe,G O Agu et al.
O A Adeoluwa et al.
Background: Terminalia ivorensis A. Chev (Combretaceae) is a medicinal plant used in folk medicine in the management of pain, rheumatic condition, gastroenteritis and as a tranquilizer in psychotic disorder. ...
Tumor recurrence and drug resistance properties of side population cells in high grade ovary cancer [0.03%]
高侵袭性卵巢癌侧群细胞的肿瘤复发及耐药特性研究
Q-H Zhang,H-T Dou,P Xu et al.
Q-H Zhang et al.
Introduction: The presence of subset of cancer stem cells (CSCs) called "Side population" (SP) cells has been identified in several solid tumors, responsible for treatment failure especially chemotherapy, and cancer relap...