Preclinical Targeting of the PGRMC1-CK2 Axis with Silmitasertib: A Potential Strategy for Lung Adenocarcinoma Therapy [0.03%]
靶向肺腺癌治疗的PGRMC1-CK2轴的临床前Silmitasertib研究
S Solaipriya,M Anbalagan,V Sivaramakrishnan
S Solaipriya
Progesterone receptor membrane component 1 (PGRMC1) is a pleiotropic protein over-expressed in lung adenocarcinoma (LUAD). The precise molecular mechanisms underlying the signature motif of Casein kinase (CK2) presence in PGRMC1 and their r...
Ognjenka Rahić,Sabina Behrem,Amina Tucak-Smajić et al.
Ognjenka Rahić et al.
Four natural sweeteners (sucrose, xylitol, fructose, and isomalt) were selected to examine the influence of their qualities and amounts on the characteristics of orodispersible films. Sodium carboxymethylcellulose (2% w/w) was utilized as t...
Characterization of Diclofenac-induced Renal Damage in Normotensive and Hypertensive Rats: A Comparative Analysis [0.03%]
萘普生致 normotensive和hypertensive大鼠肾损害的比较研究
Thaise Boeing,Alana Bittencourt F Lima,Maria Eduarda Busana et al.
Thaise Boeing et al.
Background: Diclofenac is the non-steroidal anti-inflammatory drug (NSAID) mostly prescribed worldwide, but it is highly associated with hypertension and acute kidney injury. Despite that, little information is available ...
Ian Richard Lucena Andriolo,Larissa Venzon,Luisa Mota da Silva
Ian Richard Lucena Andriolo
It is known that reactive oxygen species cause abnormal immune responses in the gut during inflammatory bowel diseases (IBD). Therefore, oxidative stress has been theorized as an agent of IBD development and antioxidant compounds such as vi...
An Observational Study on Cosmetics Use-related Adverse Effects: Cosmetovigilance Need of the Day [0.03%]
化妆品使用相关不良反应的观察研究：当今的化妆品 vigilance需求
Geetika Mehta,Daksh Raj Tyagi,Monika Sachdeva et al.
Geetika Mehta et al.
Introduction: The pursuit of aesthetic attractiveness and increased awareness have contributed significantly to the growth of the cosmetic industry. However, it is crucial to recognize that even the minimal use of cosmeti...
Observational Study
Drug research. 2024 Apr;74(4):164-170. DOI:10.1055/a-2251-6655 2024
Therapeutic Potential of Diosgenin in Amelioration of Carbon Tetrachloride-Induced Murine Liver Injury [0.03%]
异薯蓣皂素在减轻四氯化碳诱导的小鼠肝脏损伤中的治疗潜力
Mohamad-Hasan Ghosian-Moghaddam,Parvaneh Mohseni-Moghaddam,Mehrdad Roghani
Mohamad-Hasan Ghosian-Moghaddam
Diosgenin is a sapogenin with antidiabetic, antioxidant, and anti-inflammatory properties. The current study investigated whether diosgenin could ameliorate carbon tetrachloride (CCL4)-induced liver injury. To cause liver injury, CCL4 was i...
Saad Mohammed,Tarique Mahmood,Arshiya Shamim et al.
Saad Mohammed et al.
Glipizide is an oral glucose-lowering medication that is beneficial for the treatment of type 2 diabetes. This study compiles exhaustively all accessible information on glipizide, from preclinical to clinical studies. Glipizide may be used ...
From Hypertension to Beyond: Unraveling the Diverse Mechanisms of Olmesartan in Disease Modulation [0.03%]
从高血压到更多领域：奥美沙坦在疾病调节中的多样机制解析
Laiba Rind,Tarique Mahmood,Mohammed Haris Siddiqui et al.
Laiba Rind et al.
Olmesartan, originally known for its antihypertensive properties, exhibits promising potential in addressing inflammation-mediated diseases. As an angiotensin II receptor blocker (ARB), Olmesartan influences pivotal pathways, including reac...
The Perspective of Using Flow Cytometry for Unpuzzling Hypoxia-Inducible Factors Signalling [0.03%]
使用流式细胞术解析缺氧诱导因子信号的视角
Vishal J Patel,Amit Joharapurkar,Mukul R Jain
Vishal J Patel
Hypoxia-inducible factors (HIFs) are transcription factors that are responsible for adapting to the changes in oxygen levels in the cellular environment. HIF activity determines the expression of cellular proteins that control the developme...
Understanding the Potential of mRNA as Biomarker to Revolutionize Diagnosis of Colorectal Cancer [0.03%]
理解mRNA作为生物标志物在结肠癌诊断中革命性的潜能
Rina Das,Dinesh Kumar Mehta,Nidhi Gupta
Rina Das
MicroRNA as potential biomarker for early diagnosis, differentiating various stages, interpreting the success of postoperative curative surgery and predicting early relapse of Colorectal cancer.In the realm of medical research, the quest to...