Interaction of Purine and its Derivatives with A1, A2-Adenosine Receptors and Vascular Endothelial Growth Factor Receptor-1 (Vegf-R1) as a Therapeutic Alternative to Treat Cancer [0.03%]
嘌呤及其衍生物与A1、A2腺苷受体和血管内皮生长因子受体-1（VEGF-R1）的相互作用作为治疗癌症的替代疗法
Lauro Figueroa,Marcela Rosas,Magdalena Alvarez et al.
Lauro Figueroa et al.
Background: There are several studies that indicate that cancer development may be conditioned by the activation of some biological systems that involve the interaction of different biomolecules, such as adenosine and vas...
Evaluation of the Efficacy of Tofacitinib, a JAK Inhibitor, in Alleviating Sepsis-Induced Multiple Organ Dysfunction Syndrome [0.03%]
托法替尼(一种JAK抑制剂)改善脓毒症诱导的多器官功能障碍综合征的有效性评价
Vaishnavi Singh,Kavita Joshi,Samit Chatterjee et al.
Vaishnavi Singh et al.
Sepsis, a life-threatening condition triggered by an uncontrolled response to infection, results in a systemic inflammatory response syndrome (SIRS) and the failure of multiple organs leading to multiple organ dysfunction (MODS). In the pre...
Amputation Risk in Type II Diabetes Mellitus Patients Treated with SGLT-2 Inhibitors: A Systematic Literature Review of Randomized Clinical Trials [0.03%]
钠-葡萄糖协同转运蛋白-2抑制剂治疗2型糖尿病患者截肢风险的系统文献回顾：随机临床试验分析
Farazul Hoda,Mohammad Chand Jamali,Mawrah Arshad et al.
Farazul Hoda et al.
Background: SGLT-2 inhibitors, prescribed for type 2 diabetes, have a heightened risk of amputation. The FDA issued a warning in May 2017, leading to the inclusion of a cautionary label. Vigilance is essential for patient...
Assessing the Compatibility of Menatetrenone with Excipients: A Spectroscopic Approach and Implication in Drug Formulation Development [0.03%]
光谱法评估梅纳特伦与辅料的相容性及其在药物制剂开发中的应用研究
Widhilika Singh,Poonam Kushwaha,Shom Prakash Kushwaha
Widhilika Singh
An experiment was conducted to evaluate the compatibility of menatetrenone with selected pharmaceutical excipients. Fourier Transform Infrared Spectroscopy (FTIR) was used to assess drug-excipient compatibility. The present research systema...
Sonali Saha,Kongkana Kalita,Kavita Dhinsa et al.
Sonali Saha et al.
Background: Mouthwashes, as a form of antimicrobial delivery system, rank among the safest and most effective vehicles, particularly in the case of young children. This is attributed to their ability to distribute therape...
Randomized Controlled Trial
Drug research. 2024 Oct;74(8):415-420. DOI:10.1055/a-2368-4336 2024
Saliva Versus Plasma Therapeutic Drug Monitoring of Valproic Acid in Jordanian Patients [0.03%]
约旦患者的伐普瑞米治疗药物监测：唾液与血浆的比较
Nasir Idkaidek,Aya Al-Tarawneh,Laith Alshoaibi et al.
Nasir Idkaidek et al.
Therapeutic drug monitoring is used to ensure that medications are prescribed and administered according to safe doseage advice and for the purpose of achieving the desired therapeutic effects in patients. Several methods are used to perfor...
Comparative Study
Drug research. 2024 Sep;74(7):314-324. DOI:10.1055/a-2357-8095 2024
Genito Urinary Infection and Urinary Tract Infection in Patients with Type 2 Diabetes Mellitus Receiving SGLT2 Inhibitors: Evidence from a Systematic Literature Review of Landmark Randomized Clinical Trial [0.03%]
钠-葡萄糖协同转运蛋白2抑制剂治疗的2型糖尿病患者发生泌尿生殖系感染和尿路感染的系统文献回顾及见解：以里程碑式的随机临床试验为基础
Mawrah Arshad,Farazul Hoda,Nasir Ali Siddiqui et al.
Mawrah Arshad et al.
Background and purpose: SGLT2 inhibitors are class of drugs that are used in adults with type 2 diabetes through a novel mechanism of action by reducing renal tubular glucose reabsorption, leading to a reduction in blood ...
Cerebroprotective Potential of Andrographolide Nanoparticles: In silico and In vivo Investigations [0.03%]
andrographolide纳米粒的脑保护潜力：基于计算机模拟和体内实验的研究
Lakshmi Charitha Rudrala,Ranadheer Reddy Challa,Sibbala Subramanyam et al.
Lakshmi Charitha Rudrala et al.
Ischemic stroke remains the leading cause of death and disability, while the main mechanisms of dominant neurological damage in stroke contain oxidative stress and inflammation. Docking studies revealed a binding energy of - 6.1 kcal/mol fo...
HIF Stabilizer Desidustat Protects against Complement-Mediated Diseases [0.03%]
HIF稳定剂Desidustat对抗补体介导的疾病的作用
Vishal J Patel,Amit A Joharapurkar,Samadhan G Kshirsagar et al.
Vishal J Patel et al.
Complement cascade is a defence mechanism useful for eliminating pathogenic microorganisms and damaged cells. However, activation of alternative complement system can also cause inflammation and promote kidney and retinal disease progressio...
Exploring the Anticonvulsant Properties of a Celecoxib-Phospholipid Conjugate: Synthesis, Activation, and Evaluation of Cytotoxicity [0.03%]
雷帕霉素联合白消安-磷脂共轭体的合成、激活及细胞毒性评价探究英文标题翻译结果如下：探索白消安-磷脂共轭体抗惊厥特性：合成，激活和评估细胞毒性
Puthusserikkunnu B Anjali,Natarajan Jawahar,Mandadhi R Praharsh Kumar et al.
Puthusserikkunnu B Anjali et al.
Background: Epilepsy poses a significant global health challenge, particularly in regions with limited financial resources hindering access to treatment. Recent research highlights neuroinflammation, particularly involvin...