In Silico Identification of Promising PDE5 Inhibitors Against Hepatocellular Carcinoma Among Natural Derivatives: A Study Involving Docking and ADMET Analysis [0.03%]
基于分子对接和ADMET分析从天然产物衍生物中筛选肝癌潜在PDE5抑制剂的虚拟药物设计研究
Anil Kumar,Dharmendra Rajput,Naveen Gupta et al.
Anil Kumar et al.
Hepatocellular carcinoma (HCC) represents a significant worldwide health challenge due to its high mortality rate, underscoring the need for advanced therapeutic strategies. This study employs a computer-based method to identify potential p...
J S Gayathri,S Swathi Krishna,M P Rakesh
J S Gayathri
Tyrosine Kinase inhibitor (TKI) is a class of drugs that interfere with protein kinases' signal transduction pathways through an array of inhibitory mechanisms. Tyrosine kinases (TK) have an inevitable role in downstream signal transduction...
Phosphatidylserine Topically Attenuates Imiquimod-induced Psoriasis Through Inflammation Inhibition in Mice [0.03%]
磷脂酰丝氨酸通过抑制小鼠炎症来缓解咪喹莫德诱导的银屑病
Bahareh Farasati Far,Partow Mirzaee Saffari,Razieh Mohammad Jafari et al.
Bahareh Farasati Far et al.
Background: Psoriasis is a chronic skin condition that is associated with persistent inflammation and skin lesions. Topical therapy has been a promising approach to the alleviation of psoriasis through the application of ...
Synthesis and Characterization of Acacia-Stabilized Doxorubicin-Loaded Gold Nanoparticles for Breast Cancer Therapy [0.03%]
用于乳腺癌治疗的金纳米颗粒载多柔比星的合成与表征（稳定剂：阿拉伯胶）
Laxmi Devi,Poonam Kushwaha,Tarique Mahmood Ansari et al.
Laxmi Devi et al.
The targeted delivery of drugs is vital in breast cancer treatment due to its ability to produce long-lasting therapeutic effects with minimal side effects. This study reports the successful development of doxorubicin hydrochloride (DOX)-lo...
Explore the Role of the Sphingosine-1-Phosphate Signalling as a Novel Promising Therapeutic Target for the Management of Parkinson's Disease [0.03%]
探讨鞘氨醇-1-磷酸信号通路作为潜在治疗靶点在帕金森病管理中的作用
Manoj Bisht,Jai Parkash Kadian,Tanuj Hooda et al.
Manoj Bisht et al.
Sphingosine-1-phosphate (S1P) is a cellular signalling molecule derived from sphingosine, which is a pro-apoptotic sphingolipid. Sphingolipids control various cellular actions like growth, homeostasis, and stress-related responses. The main...
Exploring the HPLC Profiling and Antioxidant Potency in Methanolic Extracts of Curcuma longa L. Rhizomes [0.03%]
运用HPLC分析Curcuma longa L根茎的甲醇提取物中的黄酮类成分及其抗氧化能力探索研究
Babita Shukla,Poonam Kushwaha
Babita Shukla
In this exploration of Curcuma longa Linn., commonly known as turmeric, renowned for its therapeutic history, our study focuses on the bioactive compound curcumin. We established and validated an HPLC method for precise curcumin quantificat...
A Comparative Analysis of ADRs under Obeticholic Acid and Ursodeoxycholic Acid in Cholestatic Liver Diseases Using the FAERS Database [0.03%]
基于FAERS数据库的奥贝胆酸与熊去氧胆酸治疗淤胆型肝病的不良反应比较分析
Meng Zhu,Linghui Tao,Feiye Zhu et al.
Meng Zhu et al.
Background: The objective of this study was to compare the safety profiles of OCA and UDCA for the treatment of PBC using the FDA Adverse Event Reporting System database. ...
Comparative Study
Drug research. 2024 Nov;74(9):464-474. DOI:10.1055/a-2401-4700 2024
Bioflavonoid Daidzein: Therapeutic Insights, Formulation Advances, and Future Directions [0.03%]
大豆异黄酮的大豆苷元：治疗作用、制剂进展及未来方向
Sana Ahmad,Farogh Ahsan,Javed Akhtar Ansari et al.
Sana Ahmad et al.
Bioflavonoids, are a diverse group of phytonutrients that are widely distributed in fruits, vegetables, grains, teas, and certain medicinal herbs. They are characterized by their antioxidant properties and play essential roles in plant biol...
Unraveling the Interplay of 5-hydroxytryptamine-3 and N-methyl-d-aspartate Receptors in Seizure Susceptibility [0.03%]
解开5-羟色胺-3和N-甲基-D-天冬氨酸受体在癫痫易感性中的相互作用
Samane Jahanabadi,Mohammadreza Riahi Madvar
Samane Jahanabadi
Background: Epilepsy, a prevalent neurological disorder characterized by recurrent seizures, presents significant challenges in treatment and management. This study aimed to evaluate the effect of tropisetron, a selective...
The Effect of Trientine on AlCl3-Induced Cognitive Dysfunction and Biochemical Changes in the Hippocampus of Rats [0.03%]
Trientine对AlCl3致大鼠海马认知障碍及生化改变的影响
Kian Mousavi-Nasab,Mohammad Amani,Sara Mostafalou
Kian Mousavi-Nasab
Cognitive impairments affect millions of people worldwide with an increasing prevalence. Research on their etiology and treatment is developing, nevertheless significant gaps remain. Trientine (TETA), as a copper chelator, has been shown to...