Levocabastine ameliorates cyclophosphamide-induced nephrotoxicity in Swiss albino mice via NF-κB/cleaved caspase-3/TGF-β signaling pathways [0.03%]
乐伐宝司丁通过NF-κB/cleaved caspase-3/TGF-β信号通路改善环磷酰胺致瑞士白化小鼠肾毒性
Wasim Akram,Abul Kalam Najmi,M Mumtaz Alam et al.
Wasim Akram et al.
Cyclophosphamide (CP) is a potent anticancer drug, but nephrotoxicity is one of the vital organ toxicities that it causes as a side effect. We tried to evaluate the nephroprotective effect of levocabastine (LEV) in CP-induced nephrotoxicity...
Possible Drug-Drug Interactions Between Mesalamine and Tricyclic Antidepressants Through CYP2D6 Metabolism - In silico and In vitro Analyses [0.03%]
基于CYP2D6代谢的美沙拉嗪与三环类抗抑郁药之间可能的药物相互作用：计算分析和体外研究
Melek B Ozen,Isil Gazioglu,Ozden Ozgun Acar et al.
Melek B Ozen et al.
Mesalamine (mesalazine, 5-aminosalicylic acid, 5-ASA) is an essential anti-inflammatory agent both used for therapy and as a remission control in patients with inflammatory bowel diseases (IBD) such as ulcerative colitis (UC). Tricyclic ant...
Effects of Vitamin B6 on the Expression and Development of Tolerance to Morphine Stimulating Effects on Locomotor Activity in Mice [0.03%]
维生素B6对吗啡刺激小鼠活动能力耐受性表达和发展的影响研究
Amir Abbas Barzegari,Maryam Azaddar,Mohammad-Reza Ghiasi et al.
Amir Abbas Barzegari et al.
Chronic use of morphine may induce tolerance to its different pharmacological effects. Vitamin B6 has a central role, as a cofactor, in the biosynthesis of neurotransmitters that are involve in morphine's effects. Moreover, this vitamin aff...
In situ Forming Nanoemulgel for Diabetic Retinopathy: Development, characterization, and in vitro efficacy assessment [0.03%]
就地形成的治疗糖尿病视网膜病变的纳米乳胶凝胶：开发、表征及体外疗效评估
Soumya Singh,Poonam Kushwaha,Sujeet Gupta
Soumya Singh
Diabetic retinopathy, the most common microvascular complication of diabetes mellitus, is the leading cause of vision impairment worldwide. Flavonoids with antioxidant properties have been shown to slow its progression. Myricetin, a flavono...
A Review of Potentials of Carica Papaya Leaves in Dengue Viral Infection - Insights of Clinical and Preclinical Studies [0.03%]
番木瓜叶在登革热病毒感染中的潜力综述-临床和前临床研究的新见解
Naina Mohamed Pakkir Maideen,Rajkapoor Balasubramanian,Arun Shanmugam et al.
Naina Mohamed Pakkir Maideen et al.
One of the most widespread arboviral diseases in the world, dengue virus disease (DVD) is primarily found in tropical and subtropical regions, affecting 129 countries. The main way that the dengue virus (DENV) spreads is through the bite of...
Fragment-Based Drug Discovery of KIF11 Inhibitors for Glioblastoma Treatment: Molecular Insights and Therapeutic Potential [0.03%]
基于片段的KIF11抑制剂药物发现及其在胶质母细胞瘤治疗中的分子见解和潜在作用
Qais Ahmad Naseer,Cao Xuexian,Deng Yimai et al.
Qais Ahmad Naseer et al.
Fragment based novel drug identification and its validation through use of molecular dynamics and simulations.Comparing primary microcephaly genes with glioblastoma expression profiles reveals potential oncogenes, with proteins that support...
1α,25(OH)2D3 Regulates the TGF-β1/Samd Signaling Pathway Inhibition of Hepatic Stellate Cell Activation [0.03%]
1α,25(OH)2D3通过调控TGF-β1/Samd信号通路抑制肝星状细胞活化
Yihan Zhao,Jianghao Fan,Jia Wang et al.
Yihan Zhao et al.
To investigate the effect of 1α,25(OH)2D3 on hepatic stellate cells and the mechanism of the TGF-β1/Smad signaling pathway.LX2 cells were treated with TGF-β1 and different concentrations of 1α,25(OH)2D3. Cell proliferation was assessed ...
Thymoquinone Mediates Müller Cell Apoptosis via miR-29b/SP1 Pathway: A Potential Therapeutic Approach in Diabetic Retinopathy [0.03%]
补骨脂素通过miR-29b/SP1信号通路介导糖尿病视网膜病变中穆勒细胞的凋亡：潜在的治疗方法
Khalid M Alkharfy,Ajaz Ahmad,Mohammad Raish et al.
Khalid M Alkharfy et al.
This study aims to explore the therapeutic potential of thymoquinone (TQ) in DR by assessing its effects on Müller cell apoptosis through modulation of the miR-29b/SP1 pathway in a diabetic animal model.Healthy C57BL/6 mice (25 g) were use...
Repeated injections of isovaline lead to analgesic tolerance and cross-tolerance to salicylate but not to morphine in male mice [0.03%]
异瓦尔氨酸反复注射导致小鼠痛觉过敏及水杨酸但不是吗啡的交叉耐受性
Maryam Moghimian,Reza Nazari-Motlagh,Seyed Sajjad Alavi-Kakhki et al.
Maryam Moghimian et al.
Tolerance to the antinociceptive effects of opioids is a major concern. Studies have shown that chronic use of non-steroidal anti-inflammatory (NSAIDs) causes significant tolerance and cross-tolerance to morphine. Chronic NSAIDs use can inc...
WEE1 Inhibition by AZD1775 Augments Colorectal Cancer Cells Susceptibility to VE-822-induced DNA Damage and Apoptosis [0.03%]
AZD1775通过抑制WEE1增强VE-822诱导的结直肠癌细胞DNA损伤和凋亡
Ainaz Mihanfar,Faezeh Asghari,Maryam Majidinia
Ainaz Mihanfar
WEE1 is a key tyrosine kinase involved in the cell cycle regulation with potent anticancer effects in various cancer types including colorectal cancer. Recent studies have focused on the potential of combinational inhibition of Ataxia Telan...