Protective Effects of Niclosamide Ethanolamine Against Testosterone-Induced Benign Prostatic Hyperplasia in Rats [0.03%]
尼卡巴嗪乙醇胺对雄激素诱导的良性前列腺增生大鼠的保护作用
Ali Hussein Jasim,Ahmed Rahmah Abu-Raghif,Zeena Ayad Hussein
Ali Hussein Jasim
Benign prostatic hyperplasia is a common urological condition in aging men. The anthelmintic agent niclosamide ethanolamide exhibits a wide range of pharmacological activities. This study aimed to evaluate the protective effect of niclosami...
Enhancing Doxorubicin Sensitivity in Osteosarcoma Cancer Cells: Unveiling the Role of Resveratrol-Induced Oxidative DNA Damage [0.03%]
白藜醇诱导的氧化DNA损伤在提高成骨肉瘤癌细胞对阿霉素敏感性中的作用
Mohammad Reza Bazavar,Hamed Helali,Linda Mohammadzadeh Boukani et al.
Mohammad Reza Bazavar et al.
Our current research aims to investigate how Resveratrol influences DOX-induced apoptosis in Saos-2 cells resulting from DNA damage.Saos-2 cells were cultured with DOX, and an MTT assay was conducted to evaluate cell viability. The expressi...
Asad Ahmad,Juber Akhtar,Mohammad Ahmad et al.
Asad Ahmad et al.
Both local and systemic medication delivery benefit greatly from the sublingual and buccal modes of administration. They have shown to be a successful substitute for the conventional oral route, particularly in situations requiring a quick ...
Design and Optimization of Novel Pyrimidine-Morpholine Hybrids Through Computational Approaches for SRC Kinase Inhibitory Activity [0.03%]
基于计算方法设计和优化SRC激酶抑制剂新型嘧啶-吗啉杂环化合物的研究与优化
Knolin K Thachil,V Soumya
Knolin K Thachil
Src (non receptor tyrosine kinase) plays a role in multiple pathways leading to tumor survival, proliferation and metastasis. Inhibiting Src kinase would be a therapeutic benefit in Src dependent cancers. Most of the nitrogen containing het...
A Randomized, Controlled Study Evaluating Effects of Saccharomyces boulardii in Adult Patients with Asthma [0.03%]
一项随机对照研究：评估酿酒酵母对哮喘成人患者的影响
Kavosh Ansari Dezfouli,Mahboubeh Darban,Maral Hemmati et al.
Kavosh Ansari Dezfouli et al.
To determine the potential benefit of adding Saccharomyces boulardii (S. boulardii) probiotic supplementation to conventional treatments in asthmatic patients.In this randomized, double-blinded, and placebo-controlled trial 50 asthmatic pat...
Therapeutic Potential of Sotagliflozin in Animal Models of Non-alcoholic Fatty Liver Disease with and without Diabetes [0.03%]
Sotagliflozin的治疗潜力：用于糖尿病和非糖尿病动物模型的非酒精性脂肪肝病的研究
Nitin J Deshmukh,M S Kalshetti,Mohan Patil et al.
Nitin J Deshmukh et al.
Sotagliflozin, a dual SGLT1/2 inhibitor, enhances glucagon like peptide-1 (GLP-1) levels and GLP-1 receptor agonists are used to manage non-alcoholic fatty liver disease (NAFLD). Study investigates the effects of sotagliflozin on NAFLD, alo...
Levocabastine ameliorates cyclophosphamide-induced nephrotoxicity in Swiss albino mice via NF-κB/cleaved caspase-3/TGF-β signaling pathways [0.03%]
乐伐宝司丁通过NF-κB/cleaved caspase-3/TGF-β信号通路改善环磷酰胺致瑞士白化小鼠肾毒性
Wasim Akram,Abul Kalam Najmi,M Mumtaz Alam et al.
Wasim Akram et al.
Cyclophosphamide (CP) is a potent anticancer drug, but nephrotoxicity is one of the vital organ toxicities that it causes as a side effect. We tried to evaluate the nephroprotective effect of levocabastine (LEV) in CP-induced nephrotoxicity...
Possible Drug-Drug Interactions Between Mesalamine and Tricyclic Antidepressants Through CYP2D6 Metabolism - In silico and In vitro Analyses [0.03%]
基于CYP2D6代谢的美沙拉嗪与三环类抗抑郁药之间可能的药物相互作用：计算分析和体外研究
Melek B Ozen,Isil Gazioglu,Ozden Ozgun Acar et al.
Melek B Ozen et al.
Mesalamine (mesalazine, 5-aminosalicylic acid, 5-ASA) is an essential anti-inflammatory agent both used for therapy and as a remission control in patients with inflammatory bowel diseases (IBD) such as ulcerative colitis (UC). Tricyclic ant...
Effects of Vitamin B6 on the Expression and Development of Tolerance to Morphine Stimulating Effects on Locomotor Activity in Mice [0.03%]
维生素B6对吗啡刺激小鼠活动能力耐受性表达和发展的影响研究
Amir Abbas Barzegari,Maryam Azaddar,Mohammad-Reza Ghiasi et al.
Amir Abbas Barzegari et al.
Chronic use of morphine may induce tolerance to its different pharmacological effects. Vitamin B6 has a central role, as a cofactor, in the biosynthesis of neurotransmitters that are involve in morphine's effects. Moreover, this vitamin aff...
In situ Forming Nanoemulgel for Diabetic Retinopathy: Development, characterization, and in vitro efficacy assessment [0.03%]
就地形成的治疗糖尿病视网膜病变的纳米乳胶凝胶：开发、表征及体外疗效评估
Soumya Singh,Poonam Kushwaha,Sujeet Gupta
Soumya Singh
Diabetic retinopathy, the most common microvascular complication of diabetes mellitus, is the leading cause of vision impairment worldwide. Flavonoids with antioxidant properties have been shown to slow its progression. Myricetin, a flavono...